Zobrazeno 1 - 10
of 122
pro vyhledávání: '"Organotypic brain slices"'
Autor:
Katharina Steiner, Christian Humpel
Publikováno v:
Frontiers in Bioscience-Landmark, Vol 29, Iss 6, p 232 (2024)
Background: Alzheimer’s disease is characterized by extracellular beta-amyloid plaques, intraneuronal tau neurofibrillary tangles and excessive neurodegeneration. The mechanisms of neuron degeneration and the potential of these neurons to form new
Externí odkaz:
https://doaj.org/article/dd8e08737a5c46e1a02884f872d5a6f2
Autor:
Dhwani S. Korde, Christian Humpel
Publikováno v:
Biomolecules, Vol 14, Iss 2, p 165 (2024)
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder that is characterized by amyloid-beta (Aβ) plaques and tau neurofibrillary tangles (NFT). Modelling aspects of AD is challenging due to its complex multifactorial etiology and pa
Externí odkaz:
https://doaj.org/article/5bb52e1e30a748fdaa9f5c8ca1746252
Autor:
Katharina Steiner, Christian Humpel
Publikováno v:
Biomolecules, Vol 14, Iss 1, p 3 (2023)
In Alzheimer’s disease, the blood–brain barrier breakdown, blood vessel damage and re-organization are early events. Deposits of the small toxic peptide beta-amyloid (Aβ) cause the formation of extracellular plaques and accumulate in vessels dis
Externí odkaz:
https://doaj.org/article/4f82a943b6ef42909067c7b997cdf526
Autor:
Katharina Steiner, Christian Humpel
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 16 (2022)
Ischemic stroke is a severe insult in the brain causing cell death, inflammation, and activation of microglia. Microglia are the immune cells of the brain and play a role in any inflammatory process during neurodegeneration. Microglia are round amebo
Externí odkaz:
https://doaj.org/article/7705bc74d23c4a7aa63fae598edab0c5
Autor:
Sara Merlo, Grazia Ilaria Caruso, Dhwani Sunil Korde, Alla Khodorovska, Christian Humpel, Maria Angela Sortino
Publikováno v:
Biomolecules, Vol 13, Iss 2, p 373 (2023)
Melatonin (MEL) is a neurohormone endowed with neuroprotective activity, exerted both directly on neuronal cells and indirectly through modulation of responsive glial cells. In particular, MEL’s effects on microglia are receptor-mediated and in par
Externí odkaz:
https://doaj.org/article/69a68f1af5e0458789b05c346de70dca
Akademický článek
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Autor:
Katharina Steiner, Christian Humpel
Publikováno v:
Frontiers in Neurology, Vol 12 (2021)
Alzheimer's disease is a severe neurodegenerative disorder of the brain, characterized by beta-amyloid plaques, tau pathology, and cell death of cholinergic neurons, resulting in loss of memory. The reasons for the damage of the cholinergic neurons a
Externí odkaz:
https://doaj.org/article/41fd6f53194c461fa6766ae0ce9d9c56
Autor:
Dhwani S. Korde, Christian Humpel
Publikováno v:
Biomolecules, Vol 12, Iss 9, p 1164 (2022)
Tau pathology extends throughout the brain in a prion-like fashion through connected brain regions. However, the details of the underlying mechanisms are incompletely understood. The present study aims to examine the spreading of P301S aggregated tau
Externí odkaz:
https://doaj.org/article/dfb3ed49f6ac486685d167a8720d7f11
Autor:
Christian Humpel
Publikováno v:
Frontiers in Aging Neuroscience, Vol 13 (2021)
Alzheimer’s disease (AD) is pathologically characterized by extracellular beta-amyloid (Aβ) plaques and intraneuronal tau tangles in the brain. A therapeutic strategy aims to prevent or clear these Aβ plaques and the Aβ-degrading enzyme neprilys
Externí odkaz:
https://doaj.org/article/a47fc36525704cc685002a2ff427c316
Akademický článek
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