Human liver organoids for disease modeling of fibrolamellar carcinoma

Autor: Nicole J.C. Narayan, David Requena, Gadi Lalazar, Lavoisier Ramos-Espiritu, Denise Ng, Solomon Levin, Bassem Shebl, Ruisi Wang, William J. Hammond, James A. Saltsman, Helmuth Gehart, Michael S. Torbenson, Hans Clevers, Michael P. LaQuaglia, Sanford M. Simon

Publikováno v: Stem Cell Reports, 17(8), 1874-1888. Cell Press
Stem Cell Reports, 17 (8)

Fibrolamellar carcinoma (FLC) is a rare, often lethal, liver cancer affecting adolescents and young adults, for which there are no approved therapeutics. The development of therapeutics is hampered by a lack of in vitro models. Organoids have shown u

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37304e3e13386ba989814f730535fbd0

Long-term culture, genetic manipulation and xenotransplantation of human normal and breast cancer organoids

Autor: Hans Clevers, Esmée J. van Vliet, Anne C. Rios, Jane E. Visvader, Sylvia F. Boj, Carol Piani, Heggert G Rebel, Oded Kopper, Johanna F. Dekkers, Carla S Verissimo, Jennifer M. Rosenbluth, Norman Sachs, Joan S. Brugge, Ellen J. Wehrens

Publikováno v: Nat Protoc
Nature Protocols, 16(4), 1936-1965. Nature Publishing Group

Organoid technology has revolutionized the study of human organ development, disease and therapy response tailored to the individual. Although detailed protocols are available for the generation and long-term propagation of human organoids from vario

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40bc869d4deafc27f9ee422c5e8cc7bf
https://europepmc.org/articles/PMC8221035/

An organoid biobank for childhood kidney cancers that captures disease and tissue heterogeneity

Autor: Calandrini, Camilla, Schutgens, Frans, Oka, Rurika, Margaritis, Thanasis, Candelli, Tito, Mathijsen, Luka, Ammerlaan, Carola, van Ineveld, Ravian L, Derakhshan, Sepide, de Haan, Sanne, Dolman, Emmy, Lijnzaad, Philip, Custers, Lars, Begthel, Harry, Kerstens, Hindrik H D, Visser, Lindy L, Rookmaaker, Maarten, Verhaar, Marianne, Tytgat, Godelieve A M, Kemmeren, Patrick, de Krijger, Ronald R, Al-Saadi, Reem, Pritchard-Jones, Kathy, Kool, Marcel, Rios, Anne C, van den Heuvel-Eibrink, Marry M, Molenaar, Jan J, van Boxtel, Ruben, Holstege, Frank C P, Clevers, Hans, Drost, Jarno, UU BETA RESEARCH, Faculteit Diergeneeskunde

Publikováno v: Nature Communications, 11(1). Nature Publishing Group
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Nature communications, 11(1):1310. Nature Publishing Group
Nature Communications

Kidney tumours are among the most common solid tumours in children, comprising distinct subtypes differing in many aspects, including cell-of-origin, genetics, and pathology. Pre-clinical cell models capturing the disease heterogeneity are currently

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::908c9651a65106083bd59aef2388f9dc
https://doi.org/10.1038/s41467-020-15155-6

Differentiated human airway organoids to assess infectivity of emerging influenza virus

Autor: Dong Wang, Shuofeng Yuan, Hin Chu, Bosco Ho-Yin Wong, Cun Li, Hans Clevers, Norman Sachs, Kwok-Yung Yuen, Xiaoyu Zhao, Wenjun Song, Kelvin K. W. To, Jasper Fuk-Woo Chan, Honglin Chen, Lei Wen, Man Chun Chiu, Jie Zhou, Vincent Kwok-Man Poon, Kenneth K. Y. Wong

Publikováno v: Proceedings of the National Academy of Sciences
Proceedings of the National Academy of Sciences of the United States of America, 115(26), 6822
Proceedings of the National Academy of Sciences of the United States of America, 115(26), 6822-6827. National Academy of Sciences
Proceedings of the National Academy of Sciences of the United States of America

Significance Influenza virus infection represents a major threat to public health worldwide. There is no biologically relevant, reproducible, and readily available in vitro model for predicting the infectivity of influenza viruses in humans. Based on

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::884872f84a5d3dd3a95892a638087289
https://doi.org/10.1073/pnas.1806308115

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