Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Organic Cation Transport Proteins/genetics"'
Autor:
Gustaf J. Wellhagen, Kim Brøsen, Mette Marie Hougaard Christensen, Benjamin Guiastrennec, Maria C. Kjellsson, Tore Bjerregaard Stage
Publikováno v:
Stage, T B, Wellhagen, G, Christensen, M M H, Guiastrennec, B, Brøsen, K & Kjellsson, M C 2019, ' Using a semi-mechanistic model to identify the main sources of variability of metformin pharmacokinetics ', Basic & Clinical Pharmacology & Toxicology, vol. 124, no. 1, pp. 105-114 . https://doi.org/10.1111/bcpt.13139
Metformin pharmacokinetics (PK) is highly variable, and researchers have for years tried to shed light on determinants of inter-individual (IIV) and inter-occasion variability (IOV) of metformin PK. We set out to identify the main sources of PK varia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e34b5c811e89bad20db91948e42c2337
https://findresearcher.sdu.dk:8443/ws/files/146453151/Using_a_semi_mechanistic_model_to_identify_the_main_sources_of_variability_of_metformin_pharmacokinetics.pdf
https://findresearcher.sdu.dk:8443/ws/files/146453151/Using_a_semi_mechanistic_model_to_identify_the_main_sources_of_variability_of_metformin_pharmacokinetics.pdf
Autor:
Robert Kraaij, Teresa Nutile, Peter Vollenweider, Cassianne Robinson-Cohen, Caroline S. Fox, André G. Uitterlinden, Sanaz Sedaghat, Cornelia M. van Duijn, Alanna C. Morrison, Meng Li, Bing Yu, Sahar Ghasemi, Zoltán Kutalik, Eric Boerwinkle, Alexanda Teumer, Jeroen van Rooij, Qiong Yang, Audrey Y. Chu, Jennifer E. Huffman, Bruce M. Psaty, Jun Liu, Najaf Amin, Jennifer A. Brody, Adrienne Tin, Rossella Sorice, Ming-Huei Chen, Marina Ciullo, Anna Köttgen, Yong Li, Ayse Demirkan, Owen M. Woodward, Melody Swen, Abbas Dehghan, Aurélien Macé, Barbara McKnight
Publikováno v:
Nature Communications
Nature communications 9 (2018). doi:10.1038/s41467-018-06620-4
info:cnr-pdr/source/autori:Tin A.; Li Y.; Brody J.A.; Nutile T.; Chu A.Y.; Huffman J.E.; Yang Q.; Chen M.-H.; Robinson-Cohen C.; Mace A.; Liu J.; Demirkan A.; Sorice R.; Sedaghat S.; Swen M.; Yu B.; Ghasemi S.; Teumer A.; Vollenweider P.; Ciullo M.; Li M.; Uitterlinden A.G.; Kraaij R.; Amin N.; van Rooij J.; Kutalik Z.; Dehghan A.; McKnight B.; van Duijn C.M.; Morrison A.; Psaty B.M.; Boerwinkle E.; Fox C.S.; Woodward O.M.; Kottgen A./titolo:Large-scale whole-exome sequencing association studies identify rare functional variants influencing serum urate levels/doi:10.1038%2Fs41467-018-06620-4/rivista:Nature communications/anno:2018/pagina_da:/pagina_a:/intervallo_pagine:/volume:9
Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
Nature Communications, 9:4228. Nature Publishing Group
Nature communications, vol. 9, no. 1, pp. 4228
Nature communications 9 (2018). doi:10.1038/s41467-018-06620-4
info:cnr-pdr/source/autori:Tin A.; Li Y.; Brody J.A.; Nutile T.; Chu A.Y.; Huffman J.E.; Yang Q.; Chen M.-H.; Robinson-Cohen C.; Mace A.; Liu J.; Demirkan A.; Sorice R.; Sedaghat S.; Swen M.; Yu B.; Ghasemi S.; Teumer A.; Vollenweider P.; Ciullo M.; Li M.; Uitterlinden A.G.; Kraaij R.; Amin N.; van Rooij J.; Kutalik Z.; Dehghan A.; McKnight B.; van Duijn C.M.; Morrison A.; Psaty B.M.; Boerwinkle E.; Fox C.S.; Woodward O.M.; Kottgen A./titolo:Large-scale whole-exome sequencing association studies identify rare functional variants influencing serum urate levels/doi:10.1038%2Fs41467-018-06620-4/rivista:Nature communications/anno:2018/pagina_da:/pagina_a:/intervallo_pagine:/volume:9
Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
Nature Communications, 9:4228. Nature Publishing Group
Nature communications, vol. 9, no. 1, pp. 4228
Elevated serum urate levels can cause gout, an excruciating disease with suboptimal treatment. Previous GWAS identified common variants with modest effects on serum urate. Here we report large-scale whole-exome sequencing association studies of serum
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09617704df3edc2b2becb350d2b1af49
https://doi.org/10.1038/s41467-018-06620-4
https://doi.org/10.1038/s41467-018-06620-4
Autor:
T, Dujic, K, Zhou, S W, Yee, N, van Leeuwen, C E, de Keyser, M, Javorský, S, Goswami, L, Zaharenko, M M, Hougaard Christensen, M, Out, R, Tavendale, M, Kubo, M M, Hedderson, A A, van der Heijden, L, Klimčáková, V, Pirags, A, Kooy, K, Brøsen, J, Klovins, S, Semiz, I, Tkáč, B H, Stricker, Cna, Palmer, L M, 't Hart, K M, Giacomini, E R, Pearson
Publikováno v:
Dujic, T, Zhou, K, Yee, S W, van Leeuwen, N, de Keyser, C E, Javorský, M, Goswami, S, Zaharenko, L, Hougaard Christensen, M M, Out, M, Tavendale, R, Kubo, M, Hedderson, M M, van der Heijden, A A, Klimčáková, L, Pirags, V, Kooy, A, Brøsen, K, Klovins, J, Semiz, S, Tkáč, I, Stricker, B H, Palmer, C N A, 't Hart, L M, Giacomini, K M & Pearson, E R 2017, ' Variants in Pharmacokinetic Transporters and Glycemic Response to Metformin : A Metgen Meta-Analysis ', Clinical Pharmacology and Therapeutics, vol. 101, no. 6, pp. 763-772 . https://doi.org/10.1002/cpt.567
Clinical Pharmacology and Therapeutics, 101(6), 763-772
Dujic, T, Zhou, K, Yee, S W, van Leeuwen, N, de Keyser, C E, Javorský, M, Goswami, S, Zaharenko, L, Christensen, M M H, Out, M, Tavendale, R, Kubo, M, Hedderson, M M, van der Heijden, A A, Klimčáková, L, Pirags, V, Kooy, A, Brøsen, K, Klovins, J, Semiz, S, Tkáč, I, Stricker, B H, Palmer, C N A, 't Hart, L M, Giacomini, K M & Pearson, E R 2017, ' Variants in Pharmacokinetic Transporters and Glycemic Response to Metformin : A MetGen Meta-Analysis ', Clinical Pharmacology & Therapeutics, vol. 101, no. 6, pp. 763-772 . https://doi.org/10.1002/cpt.567
Clinical pharmacology and therapeutics, vol 101, iss 6
Clinical Pharmacology & Therapeutics, 101(6), 763-772. Wiley-Blackwell
Clinical Pharmacology and Therapeutics, 101(6), 763-772. Wiley-Blackwell
Clinical Pharmacology and Therapeutics
Clinical Pharmacology and Therapeutics, 101(6), 763-772
Dujic, T, Zhou, K, Yee, S W, van Leeuwen, N, de Keyser, C E, Javorský, M, Goswami, S, Zaharenko, L, Christensen, M M H, Out, M, Tavendale, R, Kubo, M, Hedderson, M M, van der Heijden, A A, Klimčáková, L, Pirags, V, Kooy, A, Brøsen, K, Klovins, J, Semiz, S, Tkáč, I, Stricker, B H, Palmer, C N A, 't Hart, L M, Giacomini, K M & Pearson, E R 2017, ' Variants in Pharmacokinetic Transporters and Glycemic Response to Metformin : A MetGen Meta-Analysis ', Clinical Pharmacology & Therapeutics, vol. 101, no. 6, pp. 763-772 . https://doi.org/10.1002/cpt.567
Clinical pharmacology and therapeutics, vol 101, iss 6
Clinical Pharmacology & Therapeutics, 101(6), 763-772. Wiley-Blackwell
Clinical Pharmacology and Therapeutics, 101(6), 763-772. Wiley-Blackwell
Clinical Pharmacology and Therapeutics
Therapeutic response to metformin, a first-line drug for type 2 diabetes (T2D), is highly variable, in part likely due to genetic factors. To date, metformin pharmacogenetic studies have mainly focused on the impact of variants in metformin transport
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::b762e525da754cb923dd8b91cd06ac1f
https://research.vumc.nl/en/publications/508fedaf-498a-4e2d-91a9-f7fedd97684b
https://research.vumc.nl/en/publications/508fedaf-498a-4e2d-91a9-f7fedd97684b
Considering epidemiological, genetic and immunological data, we can conclude that the inflammatory bowel diseases are heterogeneous disorders of multifactorial etiology in which hereditability and environment interact to produce the disease. It is pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_____10561::dfeebc0348b89cdc9c357cee97eb24fc
http://olympias.lib.uoi.gr/jspui/handle/123456789/18516
http://olympias.lib.uoi.gr/jspui/handle/123456789/18516
Autor:
Fernandez-Ruiz, V. (Verónica), Kawa, M. (Milosz), Berasain, C. (Carmen), Iñiguez, M. (María), Schmitz, V. (Volker), Martinez-Anso, E. (Eduardo), Iñarrairaegui, M. (Mercedes), Herrero, J.I. (José Ignacio), Sangro, B. (Bruno), D'Avola, D. (Delia), Quiroga, J. (Jorge), Qian, C. (Cheng), Prieto, J. (Jesús)
BACKGROUND & AIMS: Cell therapy has been used to attenuate liver injury. Here we evaluated whether genetic engineering of either bone marrow-derived mononuclear cells (MNC) or endothelial progenitor cells (EPC) many enhance their hepatoprotective pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______1111::45dc96254de1598e3fe0c778b8f6a69b
https://hdl.handle.net/10171/20301
https://hdl.handle.net/10171/20301
Autor:
Ioannis Georgiou, Evangelos Liberopoulos, Vasilios T. Tzovaras, Eleni Bairaktari, Anthoula Chatzikyriakidou, M.S. Elisaf
Publikováno v:
Scandinavian journal of clinical and laboratory investigation. 67(6)
OBJECTIVE: Primary renal hypouricaemia is a hereditary clinical disorder characterized by increased renal urate clearance due to isolated renal tubular defect of uric acid transport. There have been only a few studies on primary renal hypouricaemia i