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pro vyhledávání: '"Orest T. Macina"'
Publikováno v:
Carcinogenicity ISBN: 9781003067641
Carcinogenicity
Carcinogenicity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::45998acb3a94ae510a830b9c16bb9f56
https://doi.org/10.1201/9781003067641-9
https://doi.org/10.1201/9781003067641-9
Physicochemical and Graph Theoretical Descriptors in Developmental Toxicity SAR: A Comparative Study
Publikováno v:
SAR and QSAR in Environmental Research. 11:345-362
Chemical insults to the developing fetus can lead to growth retardation, malformation, death, and functional deficits. The present study seeks to determine if physicochemical and/or graph theoretical parameters can be used to determine a structure-ac
Publikováno v:
Quantitative Structure-Activity Relationships. 19:467-474
SAR model development should be a continuous process involving formulation then experimental testing of the model, incorporation of test results into the database, then refinement of the model using the expanded database. The larger database affords
A Robust Structure-Activity Relationship (SAR) Model for Esters that Cause Skin Irritation in Humans
Publikováno v:
Toxicological Sciences. 55:215-222
A structure-activity relationship (SAR) model has been developed to discriminate skin irritant from nonirritant esters. The model is based on the physicochemical properties of 42 esters that were tested in humans for skin irritation. Nineteen physico
Autor:
Gómez J, Herbert S. Rosenkranz, Gilles Klopman, Ying Ping Zhang, Donald R. Mattison, Orest T. Macina
Publikováno v:
Teratology. 60:190-205
A CASE/MULTICASE structure activity relationship (SAR) model of developmental toxicity of chemicals in hamsters (HaDT) was developed. The model exhibited a predictive performance of 74%. The model's overall predictivity and informational content were
Publikováno v:
Journal of Chemical Information and Computer Sciences. 37:569-575
Our project aimed at developing a relation between the structure of diverse organic molecules and their ability to partition between olive oil and gas. Olive oil−gas partitions have been used as su...
Autor:
Michael Ghanooni, Gilles Klopman, Orest T. Macina, Ying P. Zhang, Herbert S. Rosenkranz, Donald R. Mattison
Publikováno v:
American Journal of Obstetrics and Gynecology. 176:799-806
OBJECTIVES: Identifying drugs or chemicals that represent hazards to human development is a continuous challenge. Of the approximately 60,000 chemicals in commercial use only 5% have been evaluated for developmental toxicity. Identification of inexpe
Publikováno v:
Inhalation Toxicology. 9:465-476
MultiCASE (version 2.80), a structure-activity relationship expert system, was applied to a series of structurally diverse compounds evaluated for sensory irritant properties. The resulting biophores (molecular fragments responsible for the observed
Autor:
Donald R. Mattison, Orest T. Macina, Ying Ping Zhang, Herbert S. Rosenkranz, Gilles Klopman, Meryl H. Karol
Publikováno v:
Inhalation Toxicology. 9:237-254
Methyl tert -butyl ether (MTBE), ethyl tert -butyl ether (ETBE), tert -amyl methyl ether (TAME), and diisopropyl ether (DIPE) were evaluated with CASE/MULTICASE structure relational models in order...
Autor:
Meryl H. Karol, Cynthia Graham, Orest T. Macina, Robert Gealy, Herbert S. Rosenkranz, Nancy B. Sussman
Publikováno v:
Human & Experimental Toxicology. 15:489-493
Clinical case reports can be important sources of information for alerting health professionals to the existence of possible health hazards. Isolated case reports, however, are weak evidence of causal relationships between exposure and disease becaus