Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Oreola Donini"'
Autor:
Brian Poligone, Carolina V. Alexander-Savino, Ellen J. Kim, Aaron R. Mangold, Jennifer Desimone, Henry K. Wong, Adam T. Rumage, Oreola Donini, Andrea Haulenbeek, Christopher J. Schaber, Richard Straube, Christopher Pullion, Alain H. Rook
Publikováno v:
Frontiers in Drug Discovery, Vol 3 (2023)
Cutaneous T-cell lymphoma (CTCL) is a rare type of non-Hodgkin lymphoma of the skin, where at later stages skin-homing malignant T-cells affect lymph nodes, blood, and visceral organs. Even though early CTCL does not affect survival, it can progress
Externí odkaz:
https://doaj.org/article/bdbb6ac6b01d45d1bb769e22f7ae38c8
Autor:
Chad J. Roy, Dylan Ehrbar, Greta Van Slyke, Jennifer Doering, Peter J. Didier, Lara Doyle-Meyers, Oreola Donini, Ellen S. Vitetta, Nicholas J. Mantis
Publikováno v:
npj Vaccines, Vol 7, Iss 1, Pp 1-10 (2022)
Abstract Inhalation of the biothreat agent, ricin toxin (RT), provokes a localized inflammatory response associated with pulmonary congestion, edema, neutrophil infiltration, and severe acute respiratory distress. The extreme toxicity of RT is the re
Externí odkaz:
https://doaj.org/article/e4fd9f46d68a4a5da1c829f98a009fc9
Autor:
Chih-Yun Lai, Albert To, Teri Ann S. Wong, Michael M. Lieberman, David E. Clements, James T. Senda, Aquena H. Ball, Laurent Pessaint, Hanne Andersen, Wakako Furuyama, Andrea Marzi, Oreola Donini, Axel T. Lehrer
Publikováno v:
Vaccine: X, Vol 9, Iss , Pp 100126- (2021)
The speed at which several COVID-19 vaccines went from conception to receiving FDA and EMA approval for emergency use is an achievement unrivaled in the history of vaccine development. Mass vaccination efforts using the highly effective vaccines are
Externí odkaz:
https://doaj.org/article/4899da1012804294873b875b8874ede5
Publikováno v:
mSphere, Vol 6, Iss 6 (2021)
ABSTRACT The development of vaccines against biothreat toxins like ricin (RT) is considered an integral component of the U.S. national security efforts. RiVax is a thermostable, lyophilized RT subunit vaccine adsorbed to aluminum salt adjuvant intend
Externí odkaz:
https://doaj.org/article/6c0d22fc327c45448021430e69185f8c
Autor:
Mahesh Kudrimoti, Amarinthia Curtis, Samar Azawi, Francis Worden, Sanford Katz, Douglas Adkins, Marcelo Bonomi, Zack Scott, Jenna Elder, Stephen T. Sonis, Richard Straube, Oreola Donini
Publikováno v:
Biotechnology Reports, Vol 15, Iss C, Pp 24-26 (2017)
Innate immunity is a key component in the pathogenesis of oral mucositis, a universal toxicity of chemoradiation therapy (CRT). Dusquetide, a novel Innate Defense Regulator, has demonstrated both nonclinical and clinical efficacy in ameliorating seve
Externí odkaz:
https://doaj.org/article/fddb9e034a23439291092f64baaef22f
Autor:
Ellen J. Kim, Aaron R. Mangold, Jennifer A. DeSimone, Henry K. Wong, Lucia Seminario-Vidal, Joan Guitart, James Appel, Larisa Geskin, Edward Lain, Neil J. Korman, Nathalie Zeitouni, Neda Nikbakht, Kenneth Dawes, Oleg Akilov, Joi Carter, Michi Shinohara, Timothy M. Kuzel, Warren Piette, Neal Bhatia, Amy Musiek, David Pariser, Youn H. Kim, Dirk Elston, Erin Boh, Madeleine Duvic, Auris Huen, Theresa Pacheco, Jeffrey P. Zwerner, Seung Tae Lee, Michael Girardi, Christiane Querfeld, Kimberly Bohjanen, Elise Olsen, Gary S. Wood, Adam Rumage, Oreola Donini, Andrea Haulenbeek, Christopher J. Schaber, Richard Straube, Christopher Pullion, Alain H. Rook, Brian Poligone
Publikováno v:
JAMA dermatology. 158(9)
ImportanceGiven that mycosis fungoides−cutaneous T-cell lymphoma (MF/CTCL) is chronic, there is a need for additional therapies with minimal short- and long-term adverse effects. Topical synthetic hypericin ointment, 0.25%, activated with visible l
Autor:
Daiqin Chen, Xin Yun, Daiheon Lee, Joseph R. DiCostanzo, Oreola Donini, Cecilia M. Shikuma, Karen Thompson, Axel T. Lehrer, Larissa Shimoda, Jung Soo Suk
Publikováno v:
Molecular Pharmaceutics. 20:750-757
Vaccine hesitancy and the occurrence of elusive variants necessitate further treatment options for coronavirus disease 2019 (COVID-19). Accumulated evidence indicates that clinically used hypertensive drugs, angiotensin receptor blockers (ARBs), may
Autor:
Albert To, Teri Ann S. Wong, Michael M. Lieberman, Karen Thompson, Aquena H. Ball, Laurent Pessaint, Jack Greenhouse, Nisrine Daham, Anthony Cook, Brandon Narvaez, Zack Flinchbaugh, Alex Van Ry, Jake Yalley-Ogunro, Hanne Andersen Elyard, Chih-Yun Lai, Oreola Donini, Axel T. Lehrer
Publikováno v:
ACS infectious diseases. 8(4)
FDA-approved and emergency use-authorized vaccines using new mRNA and viral-vector technology are highly effective in preventing moderate to severe disease; however, information on their long-term efficacy and protective breadth against severe acute
Autor:
Yi Zhang, Christina G. Towers, Upendra K. Singh, Jiuyang Liu, Maria Håkansson, Derek T. Logan, Oreola Donini, Tatiana G. Kutateladze
Publikováno v:
Structure (London, England : 1993). 30(8)
SQSTM1/p62 is an autophagic receptor that plays a major role in mediating stress and innate immune responses. Preclinical studies identified p62 as a target of the prototype innate defense regulator (IDR); however, the molecular mechanism of this pro
Autor:
Kendall B. Preston, Teri Ann S. Wong, Michael M. Lieberman, Albert To, Chih-Yun Lai, Alex Granados, Holly Thomasson, John Misamore, Jake Yalley-Ogunro, Mehtap Cabus, Hanne Andersen, Oreola Donini, Axel T. Lehrer, Theodore W. Randolph
Publikováno v:
Journal of pharmaceutical sciences. 111(12)
Zaire ebolavirus, Sudan ebolavirus, and Marburg marburgvirus are the filoviruses most commonly associated with human disease. Previously, we administered a three-dose regimen of trivalent vaccines comprising glycoprotein antigens from each virus in m