Výsledky vyhledávání - "Oreola Donini"

Akademický článek

HyBryte™ use in early-stage cutaneous T-cell lymphoma

Autor: Brian Poligone, Carolina V. Alexander-Savino, Ellen J. Kim, Aaron R. Mangold, Jennifer Desimone, Henry K. Wong, Adam T. Rumage, Oreola Donini, Andrea Haulenbeek, Christopher J. Schaber, Richard Straube, Christopher Pullion, Alain H. Rook

Publikováno v: Frontiers in Drug Discovery, Vol 3 (2023)

Cutaneous T-cell lymphoma (CTCL) is a rare type of non-Hodgkin lymphoma of the skin, where at later stages skin-homing malignant T-cells affect lymph nodes, blood, and visceral organs. Even though early CTCL does not affect survival, it can progress

Externí odkaz: https://doaj.org/article/bdbb6ac6b01d45d1bb769e22f7ae38c8

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Akademický článek

Serum antibody profiling identifies vaccine-induced correlates of protection against aerosolized ricin toxin in rhesus macaques

Autor: Chad J. Roy, Dylan Ehrbar, Greta Van Slyke, Jennifer Doering, Peter J. Didier, Lara Doyle-Meyers, Oreola Donini, Ellen S. Vitetta, Nicholas J. Mantis

Publikováno v: npj Vaccines, Vol 7, Iss 1, Pp 1-10 (2022)

Abstract Inhalation of the biothreat agent, ricin toxin (RT), provokes a localized inflammatory response associated with pulmonary congestion, edema, neutrophil infiltration, and severe acute respiratory distress. The extreme toxicity of RT is the re

Externí odkaz: https://doaj.org/article/e4fd9f46d68a4a5da1c829f98a009fc9

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Akademický článek

Recombinant protein subunit SARS-CoV-2 vaccines formulated with CoVaccine HT™ adjuvant induce broad, Th1 biased, humoral and cellular immune responses in mice

Autor: Chih-Yun Lai, Albert To, Teri Ann S. Wong, Michael M. Lieberman, David E. Clements, James T. Senda, Aquena H. Ball, Laurent Pessaint, Hanne Andersen, Wakako Furuyama, Andrea Marzi, Oreola Donini, Axel T. Lehrer

Publikováno v: Vaccine: X, Vol 9, Iss , Pp 100126- (2021)

The speed at which several COVID-19 vaccines went from conception to receiving FDA and EMA approval for emergency use is an achievement unrivaled in the history of vaccine development. Mass vaccination efforts using the highly effective vaccines are

Externí odkaz: https://doaj.org/article/4899da1012804294873b875b8874ede5

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Akademický článek

Durable Immunity to Ricin Toxin Elicited by a Thermostable, Lyophilized Subunit Vaccine

Autor: Hayley Novak, Jennifer Doering, Dylan Ehrbar, Oreola Donini, Nicholas J. Mantis

Publikováno v: mSphere, Vol 6, Iss 6 (2021)

ABSTRACT The development of vaccines against biothreat toxins like ricin (RT) is considered an integral component of the U.S. national security efforts. RiVax is a thermostable, lyophilized RT subunit vaccine adsorbed to aluminum salt adjuvant intend

Externí odkaz: https://doaj.org/article/6c0d22fc327c45448021430e69185f8c

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Telmisartan Nanosuspension for Inhaled Therapy of COVID-19 Lung Disease and Other Respiratory Infections

Autor: Daiqin Chen, Xin Yun, Daiheon Lee, Joseph R. DiCostanzo, Oreola Donini, Cecilia M. Shikuma, Karen Thompson, Axel T. Lehrer, Larissa Shimoda, Jung Soo Suk

Publikováno v: Molecular Pharmaceutics. 20:750-757

Vaccine hesitancy and the occurrence of elusive variants necessitate further treatment options for coronavirus disease 2019 (COVID-19). Accumulated evidence indicates that clinically used hypertensive drugs, angiotensin receptor blockers (ARBs), may

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97da17c49c23d6f84ed82e22cd1d8ec0
https://doi.org/10.1021/acs.molpharmaceut.2c00448

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Efficacy and Safety of Topical Hypericin Photodynamic Therapy for Early-Stage Cutaneous T-Cell Lymphoma (Mycosis Fungoides): The FLASH Phase 3 Randomized Clinical Trial

Publikováno v: JAMA dermatology. 158(9)

ImportanceGiven that mycosis fungoides−cutaneous T-cell lymphoma (MF/CTCL) is chronic, there is a need for additional therapies with minimal short- and long-term adverse effects. Topical synthetic hypericin ointment, 0.25%, activated with visible l

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::324e52e72fb4252fdfaff9693ac02e54
https://pubmed.ncbi.nlm.nih.gov/35857290

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Akademický článek

Dusquetide: Reduction in oral mucositis associated with enduring ancillary benefits in tumor resolution and decreased mortality in head and neck cancer patients

Autor: Mahesh Kudrimoti, Amarinthia Curtis, Samar Azawi, Francis Worden, Sanford Katz, Douglas Adkins, Marcelo Bonomi, Zack Scott, Jenna Elder, Stephen T. Sonis, Richard Straube, Oreola Donini

Publikováno v: Biotechnology Reports, Vol 15, Iss C, Pp 24-26 (2017)

Innate immunity is a key component in the pathogenesis of oral mucositis, a universal toxicity of chemoradiation therapy (CRT). Dusquetide, a novel Innate Defense Regulator, has demonstrated both nonclinical and clinical efficacy in ameliorating seve

Externí odkaz: https://doaj.org/article/fddb9e034a23439291092f64baaef22f

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A Recombinant Subunit Vaccine Induces a Potent, Broadly Neutralizing, and Durable Antibody Response in Macaques against the SARS-CoV-2 P.1 (Gamma) Variant

Autor: Albert To, Teri Ann S. Wong, Michael M. Lieberman, Karen Thompson, Aquena H. Ball, Laurent Pessaint, Jack Greenhouse, Nisrine Daham, Anthony Cook, Brandon Narvaez, Zack Flinchbaugh, Alex Van Ry, Jake Yalley-Ogunro, Hanne Andersen Elyard, Chih-Yun Lai, Oreola Donini, Axel T. Lehrer

Publikováno v: ACS infectious diseases. 8(4)

FDA-approved and emergency use-authorized vaccines using new mRNA and viral-vector technology are highly effective in preventing moderate to severe disease; however, information on their long-term efficacy and protective breadth against severe acute

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b3c444347a1cc422838ba8c211df2c3
https://pubmed.ncbi.nlm.nih.gov/35263081

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Dusquetide modulates innate immune response through binding to p62

Autor: Yi Zhang, Christina G. Towers, Upendra K. Singh, Jiuyang Liu, Maria Håkansson, Derek T. Logan, Oreola Donini, Tatiana G. Kutateladze

Publikováno v: Structure (London, England : 1993). 30(8)

SQSTM1/p62 is an autophagic receptor that plays a major role in mediating stress and innate immune responses. Preclinical studies identified p62 as a target of the prototype innate defense regulator (IDR); however, the molecular mechanism of this pro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::230780cf73601ced96e4680451191f79
https://pubmed.ncbi.nlm.nih.gov/35640615

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