Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Oren Yakovian"'
Publikováno v:
iScience, Vol 25, Iss 11, Pp 105282- (2022)
Summary: NRas is a key mediator of the mitogenic pathway in normal cells and in cancer cells. Its dynamics and nanoscale organization at the plasma membrane (PM) facilitate its signaling. Here, we used two-color photoactivated localization microscopy
Externí odkaz:
https://doaj.org/article/bee7726ca2f3415bb0694501caa074a0
Autor:
Julia Sajman, Oren Yakovian, Naamit Unger Deshet, Shaked Almog, Galit Horn, Tova Waks, Anat Globerson Levin, Eilon Sherman
Publikováno v:
Cells, Vol 12, Iss 18, p 2261 (2023)
T cells expressing chimeric antigen receptors (CARs) are at the forefront of clinical treatment of cancers. Still, the nanoscale organization of CARs at the interface of CAR-Ts with target cells, which is essential for TCR-mediated T cell activation,
Externí odkaz:
https://doaj.org/article/f22b6b80cb944a8d85fae3569995e08d
Autor:
Julia Sajman, Yair Razvag, Shachar Schidorsky, Seon Kinrot, Kobi Hermon, Oren Yakovian, Eilon Sherman
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-14 (2021)
Sajman et al. present a simple method to establish cell-cell interfaces for optical microscopy perpendicular to the optical axis. Widely compatible with many imaging techniques, this geometry enables to capture the cell-cell interface in the x/y plan
Externí odkaz:
https://doaj.org/article/8e4a90d0dad94a02bcc86589538fd93c
Autor:
Esther Sasson, Shira Anzi, Batia Bell, Oren Yakovian, Meshi Zorsky, Urban Deutsch, Britta Engelhardt, Eilon Sherman, Gad Vatine, Ron Dzikowski, Ayal Ben-Zvi
Publikováno v:
eLife, Vol 10 (2021)
Tight junctions (TJs) between blood-brain barrier (BBB) endothelial cells construct a robust physical barrier, whose damage underlies BBB dysfunctions related to several neurodegenerative diseases. What makes these highly specialized BBB-TJs extremel
Externí odkaz:
https://doaj.org/article/477a0873a85743b4957c023d577a0991
Publikováno v:
Cell Reports, Vol 29, Iss 11, Pp 3506-3521.e6 (2019)
Summary: T cells engage antigen-presenting cells in search for cognate antigens via dynamic cell protrusions before forming a tight immune synapse. The spatiotemporal events that may lead to rapid TCR triggering and signal amplification in microvilli
Externí odkaz:
https://doaj.org/article/8cbd0d9625274d16a8a4ce926ded47e0
Publikováno v:
Applied Sciences, Vol 10, Iss 24, p 8894 (2020)
Intracellular mechanical work facilitates multiple cell functions, such as material transport, cell motility, etc., and is indicative of the cell’s physiological condition. Still, the characterization of intracellular mechanical work and resultant
Externí odkaz:
https://doaj.org/article/729eb21152cd41f6aeeb84a9d3301313
Autor:
Eilon Sherman, Yardena Samuels, Michal Alon, Yair Neve-Oz, Rand Arafeh, Julia Sajman, Oren Yakovian
Hotspot mutations of the oncogenes BRAF and NRas are the most common genetic alterations in cutaneous melanoma. Still, the nanoscale organization and signal coupling of these proteins remain incompletely understood, particularly upon expression of on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8e463f0d4c45b9f2a5ad545614c8143e
https://doi.org/10.1158/0008-5472.c.6512581.v1
https://doi.org/10.1158/0008-5472.c.6512581.v1
Autor:
Eilon Sherman, Yardena Samuels, Michal Alon, Yair Neve-Oz, Rand Arafeh, Julia Sajman, Oren Yakovian
All supp. figures and Supp. materials and methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02b0da949c2cfe6af111dc47e1d95843
https://doi.org/10.1158/0008-5472.22427185
https://doi.org/10.1158/0008-5472.22427185
Autor:
Eilon Sherman, Rand Arafeh, Oren Yakovian, Michal Alon, Julia Sajman, Yardena Samuels, Yair Neve-Oz
Publikováno v:
Cancer Research. 81:1279-1292
Hotspot mutations of the oncogenes BRAF and NRas are the most common genetic alterations in cutaneous melanoma. Still, the nanoscale organization and signal coupling of these proteins remain incompletely understood, particularly upon expression of on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c8fa8a70fb6169176caaa823ed3c51d
https://doi.org/10.1158/0008-5472.can-20-1205
https://doi.org/10.1158/0008-5472.can-20-1205
Autor:
Esther Sasson, Shira Anzi, Batia Bell, Oren Yakovian, Meshi Zorsky, Urban Deutsch, Britta Engelhardt, Eilon Sherman, Gad Vatine, Ron Dzikowski, Ayal Ben-Zvi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::65c73ea57af415529f50faa741111c9c
https://doi.org/10.7554/elife.63253.sa2
https://doi.org/10.7554/elife.63253.sa2