Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Oren Bogin"'
Autor:
Esther Osher, Yossi Anis, Ruth Singer-Shapiro, Nataly Urshanski, Tamar Unger, Shira Albeck, Oren Bogin, Gary Weisinger, Fortune Kohen, Avi Valevski, Aviva Fattal-Valevski, Liora Sagi, Michal Weitman, Yulia Shenberger, Nadav Sagiv, Ruth Navon, Meir Wilchek, Naftali Stern
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 32, Iss 3, Pp 101300- (2024)
Tay-Sachs (TS) disease is a neurodegenerative disease resulting from mutations in the gene encoding the α-subunit (HEXA) of lysosomal β-hexosaminidase A (HexA). We report that (1) recombinant HEXA alone increased HexA activity and decreased GM2 con
Externí odkaz:
https://doaj.org/article/b46b268575554f2eb291b7d475a23c94
Autor:
Faina Bedny, Oren Bogin, Ezra Bernstein, Dov Hershkovizh, Ayelet Izhaki, Ido Wolf, Eli Brazowski, Nadir Arber, Shiran Shapira, Dina Kazanov
Publikováno v:
Journal of Clinical Oncology. 37:e14634-e14634
e14634 Background: "Personalized medicine,” is the tailoring of medical treatment to a single person aiming to maximize efficacy and minimize toxicity. Currently there is no good prediction for response to therapy. The Chick Chorioallantoic Membran
Autor:
Davide Foletti, Avinash Gill, David L. Shelton, Alexander Steiner, Mathias Rickert, Adela Hasa-Moreno, Guoyun Zhu, Jaume Pons, Andreas Crameri, Robert Henningsen, Pavel Strop, Oren Bogin, Anatoly Shcherbatko, Andrea Rossi, Meritxell Galindo Casas, Arvind Rajpal, Victor V. Bartsevich
Publikováno v:
The Journal of biological chemistry. 291(27)
The prominent role of voltage-gated sodium channel 1.7 (Nav1.7) in nociception was revealed by remarkable human clinical and genetic evidence. Development of potent and subtype-selective inhibitors of this ion channel is crucial for obtaining therape
Publikováno v:
Cancer Research. 78:1168-1168
Background Every day, millions of people are taking medications that will not help them. “Personalized medicine,” is the tailoring of medical treatment to a single person, shape his response to a particular treatment and aims to better target int
Publikováno v:
Gastroenterology. 154:S-49
Autor:
Shoshana Tel-Or, Oren Bogin, Inna Levin, Felix Frolow, Moshe Peretz, Yael Hacham, Yigal Burstein
Publikováno v:
Protein Science. 11:2561-2574
Previous research in our laboratory comparing the three-dimensional structural elements of two highly homologous alcohol dehydrogenases, one from the mesophile Clostridium beijerinckii (CbADH) and the other from the extreme thermophile Thermoanaeroba
Publikováno v:
International Journal of Peptide and Protein Research. 42:490-495
Class A and class B NAD(H)/NADP(H) coenzyme-dependent dehydrogenases distinguish between the diastereotopic hydrogens pro-R and pro-S at position 4 of the cofactor. We investigated the stereochemistry of hydride transfer in reactions catalyzed by an
Publikováno v:
Structure. 10(2):165-173
Collagen X is expressed specifically in the growth plate of long bones. Its C1q–like C–terminal NC1 domain forms a stable homotrimer and is crucial for collagen X assembly. Mutations in the NC1 domain cause Schmid metaphyseal chondrodysplasia (SM
Publikováno v:
Scopus-Elsevier
Principles of protein thermostability have been studied by comparing structures of thermostable proteins with mesophilic counterparts that have a high degree of sequence identity. Two tetrameric NADP(H)-dependent alcohol dehydrogenases, one from Clos
Publikováno v:
Letters in Peptide Science. 5:399-408
Two tetrameric secondary alcohol dehydrogenases (ADHs), one from the mesophileClostridium beijerinckii (CBADH) and the other from the extreme thermophileThermoanaerobacter brockii (TBADH), share 75% sequence identity but differ by 26°C in thermal st