The Arg-62 Residues of the TREX1 Exonuclease Act Across the Dimer Interface Contributing to Catalysis in the Opposing Protomers

Autor: Fye, Jason M., Coffin, Stephanie R., Orebaugh, Clinton D., Hollis, Thomas, Perrino, Fred W.

Publikováno v: In Journal of Biological Chemistry 18 April 2014 289(16):11556-11565

The TREX1 Exonuclease R114H Mutation in Aicardi-Goutières Syndrome and Lupus Reveals Dimeric Structure Requirements for DNA Degradation Activity

Autor: Orebaugh, Clinton D., Fye, Jason M., Harvey, Scott, Hollis, Thomas, Perrino, Fred W.

Publikováno v: In Journal of Biological Chemistry 18 November 2011 286(46):40246-40254

Tracking replication enzymology in vivo by genome-wide mapping of ribonucleotide incorporation

Autor: Williams, Jessica S, Fargo, David C, Burkholder, Adam B, Lujan, Scott A, Mieczkowski, Piotr A, Smith, Duncan J, Clausen, Maryam F, Malc, Ewa P, Kunkel, Thomas A, Orebaugh, Clinton D

Ribonucleotides are frequently incorporated into DNA during eukaryotic replication. Here we map the genome-wide distribution of these ribonucleotides as markers of replication enzymology in budding yeast, using a new 5′-DNA end-mapping method, Hydr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::97b5ddc8f84d8cc1e39830953b521bb8

Mapping Ribonucleotides Incorporated into DNA by Hydrolytic End-Sequencing.

Autor: Orebaugh CD; Genome Integrity and Structural Biology Laboratory, National Institute for Environmental Health Sciences, National Institute of Health (NIH), 111 TW Alexander Drive, Research Triangle Park, NC, 27709, USA., Lujan SA; Genome Integrity and Structural Biology Laboratory, National Institute for Environmental Health Sciences, National Institute of Health (NIH), 111 TW Alexander Drive, Research Triangle Park, NC, 27709, USA., Burkholder AB; Integrative Bioinformatics, National Institute for Environmental Health Sciences, National Institute of Health (NIH), Research Triangle Park, NC, USA., Clausen AR; Department of Medical Biochemistry and Cell Biology, University of Gothenburg, Gothenburg, Sweden., Kunkel TA; Genome Integrity and Structural Biology Laboratory, National Institute for Environmental Health Sciences, National Institute of Health (NIH), 111 TW Alexander Drive, Research Triangle Park, NC, 27709, USA. kunkel@nih.gov.

Publikováno v: Methods in molecular biology (Clifton, N.J.) [Methods Mol Biol] 2018; Vol. 1672, pp. 329-345.