Rational Design and Development of Selective BRD7 Bromodomain Inhibitors and Their Activity in Prostate Cancer.

Autor: Ordonez-Rubiano SC; Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University. Robert Heine Pharmacy Building 575 Stadium Mall Drive, West Lafayette, Indiana 47907, United States., Maschinot CA; Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University. Robert Heine Pharmacy Building 575 Stadium Mall Drive, West Lafayette, Indiana 47907, United States., Wang S; Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University. Robert Heine Pharmacy Building 575 Stadium Mall Drive, West Lafayette, Indiana 47907, United States., Sood S; Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University. Robert Heine Pharmacy Building 575 Stadium Mall Drive, West Lafayette, Indiana 47907, United States., Baracaldo-Lancheros LF; Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University. Robert Heine Pharmacy Building 575 Stadium Mall Drive, West Lafayette, Indiana 47907, United States., Strohmier BP; Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University. Robert Heine Pharmacy Building 575 Stadium Mall Drive, West Lafayette, Indiana 47907, United States., McQuade AJ; Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University. Robert Heine Pharmacy Building 575 Stadium Mall Drive, West Lafayette, Indiana 47907, United States., Smith BC; Department of Biochemistry, Program in Chemical Biology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, United States., Dykhuizen EC; Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University. Robert Heine Pharmacy Building 575 Stadium Mall Drive, West Lafayette, Indiana 47907, United States.; Purdue Center for Cancer Research, College of Pharmacy, Purdue University, 201 S University St., West Lafayette, Indiana 47907, United States.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2023 Aug 24; Vol. 66 (16), pp. 11250-11270. Date of Electronic Publication: 2023 Aug 08.

A Potent, Selective CBX2 Chromodomain Ligand and Its Cellular Activity During Prostate Cancer Neuroendocrine Differentiation.

Autor: Wang S; Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, College of Pharmacy, 201 S. University St., West Lafayette, IN, 47907, USA., Alpsoy A; Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, College of Pharmacy, 201 S. University St., West Lafayette, IN, 47907, USA.; Purdue Life Science Interdisciplinary Graduate Program, Purdue University, College of Pharmacy, 201 S. University St., West Lafayette, IN, 47907, USA., Sood S; Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, College of Pharmacy, 201 S. University St., West Lafayette, IN, 47907, USA.; Purdue Life Science Interdisciplinary Graduate Program, Purdue University, College of Pharmacy, 201 S. University St., West Lafayette, IN, 47907, USA., Ordonez-Rubiano SC; Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, College of Pharmacy, 201 S. University St., West Lafayette, IN, 47907, USA., Dhiman A; Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, College of Pharmacy, 201 S. University St., West Lafayette, IN, 47907, USA., Sun Y; Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, College of Pharmacy, 201 S. University St., West Lafayette, IN, 47907, USA., Jiao G; Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, College of Pharmacy, 201 S. University St., West Lafayette, IN, 47907, USA., Krusemark CJ; Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, College of Pharmacy, 201 S. University St., West Lafayette, IN, 47907, USA.; Purdue Center for Cancer Research, Purdue University, College of Pharmacy, 201 S. University St., West Lafayette, IN, 47907, USA., Dykhuizen EC; Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, College of Pharmacy, 201 S. University St., West Lafayette, IN, 47907, USA.; Purdue Center for Cancer Research, Purdue University, College of Pharmacy, 201 S. University St., West Lafayette, IN, 47907, USA.

Publikováno v: Chembiochem : a European journal of chemical biology [Chembiochem] 2021 Jul 01; Vol. 22 (13), pp. 2335-2344. Date of Electronic Publication: 2021 May 28.