Zobrazeno 1 - 10
of 2 290
pro vyhledávání: '"Order structure"'
Publikováno v:
Jisuanji kexue yu tansuo, Vol 18, Iss 10, Pp 2678-2689 (2024)
Graph anomaly detection has practical applications in various fields, such as cyber security, financial evaluation and medical care. Recently, contrastive-based and generative-based detection frameworks have achieved remarkable performance improvemen
Externí odkaz:
https://doaj.org/article/a7683f9bc30f4ef3bc6838afb1ea6b9f
Publikováno v:
Complex & Intelligent Systems, Vol 10, Iss 5, Pp 7143-7161 (2024)
Abstract Multi-view subspace clustering (MVC) intends to separate out samples via integrating the complementary information from diverse views. In MVC, since the structural information in the graph is crucial to the graph learning, most of the existi
Externí odkaz:
https://doaj.org/article/f351b517d59a4880b191285e39ec1cc4
Autor:
Bo Zhao, Joy Yoon, Bojie Zhang, Youmi Moon, Yue Fu, Yinyin Li, Yunlong Zhao, Hui Xiao, Ning Li
Publikováno v:
mAbs, Vol 16, Iss 1 (2024)
Methionine oxidation can substantially alter the structure and functionality of monoclonal antibodies (mAbs), especially when it occurs in the complementarity-determining regions (CDRs). It is imperative to fully understand the effects of methionine
Externí odkaz:
https://doaj.org/article/1ec92c06f523461786a1034aaa3d9648
Autor:
Yutaro Ibi, Ryuichi Nishinakamura
Publikováno v:
European Journal of Cell Biology, Vol 103, Iss 4, Pp 151450- (2024)
Over the past decade, the induction protocols for the two types of kidney organoids (nephron organoids and ureteric bud organoids) from pluripotent stem cells (PSCs) have been established based on the knowledge gained in developmental nephrology. Kid
Externí odkaz:
https://doaj.org/article/2e73dfc65caa4464838434f14f19f21c
Autor:
Mingyue Li, Victor A. Beaumont, Shahajahan Akbar, Hannah Duncan, Arch Creasy, Wenge Wang, Kelly Sackett, Lisa Marzilli, Jason C. Rouse, Hai-Young Kim
Publikováno v:
mAbs, Vol 16, Iss 1 (2024)
The higher order structure (HOS) of monoclonal antibodies (mAbs) is an important quality attribute with strong contribution to clinically relevant biological functions and drug safety. Due to the multi-faceted nature of HOS, the synergy of multiple c
Externí odkaz:
https://doaj.org/article/c60148f3693e491c9f2b5b111def14a8
Publikováno v:
Journal of Pharmaceutical Analysis, Vol 14, Iss 8, Pp 100966- (2024)
Biotherapeutic's higher order structure (HOS) is a critical determinant of its functional properties and conformational relevance. Here, we evaluated two covalent labeling methods: diethylpyrocarbonate (DEPC)-labeling and fast photooxidation of prote
Externí odkaz:
https://doaj.org/article/8af40caf50274687a4fde890db80b3b3
Autor:
Tomohiko Ikeda, Yuki Yamaguchi, Hiroaki Oyama, Aoba Matsushita, Yasuo Tsunaka, Mitsuko Fukuhara, Tetsuo Torisu, Susumu Uchiyama
Publikováno v:
Viruses, Vol 16, Iss 4, p 585 (2024)
The higher-order structure (HOS) is a critical quality attribute of recombinant adeno-associated viruses (rAAVs). Evaluating the HOS of the entire rAAV capsid is challenging because of the flexibility and/or less folded nature of the VP1 unique (VP1u
Externí odkaz:
https://doaj.org/article/4f0dadd2c7e44ce585495c7697d86bf6
Autor:
Tsega L. Solomon, Frank Delaglio, John P. Giddens, John P. Marino, Yihua Bruce Yu, Marc B. Taraban, Robert G. Brinson
Publikováno v:
mAbs, Vol 15, Iss 1 (2023)
ABSTRACTThe clinical efficacy and safety of protein-based drugs such as monoclonal antibodies (mAbs) rely on the integrity of the protein higher order structure (HOS) during product development, manufacturing, storage, and patient administration. As
Externí odkaz:
https://doaj.org/article/bb46764035b14affa365dc495b827f5d
Publikováno v:
Shipin Kexue, Vol 44, Iss 5, Pp 53-61 (2023)
Pea starch (PS) was treated by high-pressure homogenization (HPH) at different pressures (0, 20, 40, 60, 80 and 100 MPa) three times for 30 min each in order to investigate the effect of HPH treatment on rheological properties and multiscale structur
Externí odkaz:
https://doaj.org/article/dba129b2a2c84fa7950152cf4951fdaf
Publikováno v:
IEEE Access, Vol 11, Pp 66729-66741 (2023)
This paper presents a new combined automatic warehouse system that can not only realize automatic storage and sorting processes, but also process automatic replenishment requests according to inventory demand. In this system, there are two storage ar
Externí odkaz:
https://doaj.org/article/2be9802ac91944699c00753b5daa8848