Zobrazeno 1 - 10
of 60
pro vyhledávání: '"Ordan J Lehmann"'
Autor:
Jennifer C Hocking, Jakub K Famulski, Kevin H Yoon, Sonya A Widen, Cassidy S Bernstein, Sophie Koch, Omri Weiss, FORGE Canada Consortium, Seema Agarwala, Adi Inbal, Ordan J Lehmann, Andrew J Waskiewicz
Publikováno v:
PLoS Genetics, Vol 14, Iss 3, p e1007246 (2018)
The eye primordium arises as a lateral outgrowth of the forebrain, with a transient fissure on the inferior side of the optic cup providing an entry point for developing blood vessels. Incomplete closure of the inferior ocular fissure results in colo
Externí odkaz:
https://doaj.org/article/3b14a0477b30448087f0d728147cd997
Pleiotropy in FOXC1-attributable phenotypes involves altered ciliation and cilia-dependent signaling
Autor:
Serhiy Havrylov, Paul Chrystal, Suey van Baarle, Curtis R. French, Ian M. MacDonald, Jagannadha Avasarala, R. Curtis Rogers, Fred B. Berry, Tsutomu Kume, Andrew J. Waskiewicz, Ordan J. Lehmann
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-16 (2024)
Abstract Alterations to cilia are responsible for a wide range of severe disease; however, understanding of the transcriptional control of ciliogenesis remains incomplete. In this study we investigated whether altered cilia-mediated signaling contrib
Externí odkaz:
https://doaj.org/article/8843ebf9864f45db9e54d99a6ed394bb
Autor:
Lakshmi Pillai-Kastoori, Wen Wen, Stephen G Wilson, Erin Strachan, Adriana Lo-Castro, Marco Fichera, Sebastiano A Musumeci, Ordan J Lehmann, Ann C Morris
Publikováno v:
PLoS Genetics, Vol 10, Iss 7, p e1004491 (2014)
Ocular coloboma is a sight-threatening malformation caused by failure of the choroid fissure to close during morphogenesis of the eye, and is frequently associated with additional anomalies, including microphthalmia and cataracts. Although Hedgehog s
Externí odkaz:
https://doaj.org/article/5f30ed6aa6124f9aa7e1fe5f87cabb6a
Autor:
Helen Chung, Ming Ye, Chris Hanson, Oluwaseun Oladokun, Michael J Campbell, Gordon Kramer, Ordan J Lehmann
Publikováno v:
PLoS ONE, Vol 7, Iss 11, p e48355 (2012)
It is widely recognised that significant discrepancies exist between the health of indigenous and non-indigenous populations. Whilst the reasons are incompletely defined, one potential cause is that indigenous communities do not access healthcare to
Externí odkaz:
https://doaj.org/article/05403a3345a4410e913800fa12a89d90
Publikováno v:
EBioMedicine, Vol 67, Iss , Pp 103360- (2021)
Ocular morphogenesis in vertebrates is a highly organized process, orchestrated largely by intrinsic genetic programs that exhibit stringent spatiotemporal control. Alternations in these genetic instructions can lead to hereditary or nonhereditary co
Externí odkaz:
https://doaj.org/article/ca1e21d0a17243e5b6cc6d194c55f44a
Autor:
Sabrina C. Fox, Sonya A. Widen, Mika Asai-Coakwell, Serhiy Havrylov, Matthew Benson, Lisa B. Prichard, Pranidhi Baddam, Daniel Graf, Ordan J. Lehmann, Andrew J. Waskiewicz
Publikováno v:
Human Genetics. 141:1385-1407
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d0ed93959beff3ce94fadfdcb247f43a
https://doi.org/10.1007/s00439-022-02430-3
https://doi.org/10.1007/s00439-022-02430-3
Autor:
Ian M. MacDonald, Curtis R. French, Fred B. Berry, Jagannadha Avasarala, Andrew J. Waskiewicz, Serhiy Havrylov, R Curtis Rogers, Suey van Baarle, Ordan J. Lehmann, Paul W. Chrystal, Tsutomu Kume
Alterations to cilia are responsible for a wide range of severe disease; however, understanding of the transcriptional control of ciliogenesis remains incomplete. We evaluated whether ciliary dysfunction contributed to the pleiotropic phenotypes caus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1f4801a2a11d3762abfa8ed5c9a3cc3c
https://doi.org/10.1101/2020.08.13.249334
https://doi.org/10.1101/2020.08.13.249334
Autor:
Suey van Baarle, Ordan J. Lehmann, Paul W. Chrystal, Serhiy Havrylov, Curtis R. French, David B. Pilgrim, Andrew J. Waskiewicz, Ann-Marie Peturson, J. Gage Crump, Pengfei Xu, Francesca Jean
Normal body situs requires precise spatiotemporal expression of theNodal-Lefty-Pitx2cascade in the lateral plate mesoderm. The ultimate output of this patterning is establishment of the left-right axis, which provides vital cues for correct organ for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::07a9c8684ed92c80921d6554c38c4284
https://doi.org/10.1101/2020.05.28.120915
https://doi.org/10.1101/2020.05.28.120915
Publikováno v:
American journal of medical genetics. Part C, Seminars in medical geneticsREFERENCES. 184(3)
Ocular coloboma is a congenital disorder of the eye where a gap exists in the inferior retina, lens, iris, or optic nerve tissue. With a prevalence of 2-19 per 100,000 live births, coloboma, and microphthalmia, an associated ocular disorder, represen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f9f322fdc67211f7e686f7c1078558f
https://pubmed.ncbi.nlm.nih.gov/32852110
https://pubmed.ncbi.nlm.nih.gov/32852110
Autor:
Ordan J. Lehmann, Paul W. Chrystal, Nathan D. Lawson, Matthew L. Workentine, Lihua Julie Zhu, Nicole M. Munsie, Andrew J. Waskiewicz, Ann S. Grosse, Thomas Whitesell, Jae-Ryeon Ryu, Sarah J. Childs, Curtis R. French, Rui Li
Publikováno v:
Developmental biology. 453(1)
Vascular smooth muscle of the head derives from neural crest, but developmental mechanisms and early transcriptional drivers of the vSMC lineage are not well characterized. We find that in early development, the transcription factor foxc1b is express
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28162181a44daaa5088c59f38846c5ae
https://pubmed.ncbi.nlm.nih.gov/31199900
https://pubmed.ncbi.nlm.nih.gov/31199900