Dynamic Transcriptional Programs During Single NK Cell Killing: Connecting Form to Function in Cellular Immunotherapy.

Autor: Decker JT; Department of Biomedical Engineering, University of Michigan, 1600 Huron Parkway, Ann Arbor, MI 48109 USA.; Department of Cariology, Restorative Sciences, and Endodontics, University of Michigan School of Dentistry, Ann Arbor, MI 48109 USA., Hall MS; Department of Biomedical Engineering, University of Michigan, 1600 Huron Parkway, Ann Arbor, MI 48109 USA., Nanua D; Department of Biomedical Engineering, University of Michigan, 1600 Huron Parkway, Ann Arbor, MI 48109 USA., Orbach SM; Department of Biomedical Engineering, University of Michigan, 1600 Huron Parkway, Ann Arbor, MI 48109 USA.; Department of Biomedical Engineering, Rowan University, Glassboro, NJ 08028 USA., Roy J; Department of Biomedical Engineering, University of Michigan, 1600 Huron Parkway, Ann Arbor, MI 48109 USA., Angadi A; Department of Biomedical Engineering, University of Michigan, 1600 Huron Parkway, Ann Arbor, MI 48109 USA., Caton J; Department of Biomedical Engineering, University of Michigan, 1600 Huron Parkway, Ann Arbor, MI 48109 USA., Hesse L; Department of Biomedical Engineering, University of Michigan, 1600 Huron Parkway, Ann Arbor, MI 48109 USA., Jeruss JS; Department of Biomedical Engineering, University of Michigan, 1600 Huron Parkway, Ann Arbor, MI 48109 USA.; Department of Surgery, University of Michigan Medical School, Ann Arbor, MI 48109 USA., Shea LD; Department of Biomedical Engineering, University of Michigan, 1600 Huron Parkway, Ann Arbor, MI 48109 USA.

Publikováno v: Cellular and molecular bioengineering [Cell Mol Bioeng] 2024 Jul 09; Vol. 17 (3), pp. 177-188. Date of Electronic Publication: 2024 Jul 09 (Print Publication: 2024).

Computational Construction of Toxicant Signaling Networks.

Autor: Law JN; Interdisciplinary Ph.D. Program in Genetics, Bioinformatics, and Computational Biology, Blacksburg, Virginia 24061, United States., Orbach SM; Department of Chemical Engineering, Virginia Tech, Blacksburg, Virginia 24061, United States., Weston BR; Interdisciplinary Ph.D. Program in Genetics, Bioinformatics, and Computational Biology, Blacksburg, Virginia 24061, United States., Steele PA; Department of Computer Science, Virginia Tech, Blacksburg, Virginia 24061, United States., Rajagopalan P; Department of Chemical Engineering, Virginia Tech, Blacksburg, Virginia 24061, United States., Murali TM; Department of Computer Science, Virginia Tech, Blacksburg, Virginia 24061, United States.

Publikováno v: Chemical research in toxicology [Chem Res Toxicol] 2023 Aug 21; Vol. 36 (8), pp. 1267-1277. Date of Electronic Publication: 2023 Jul 20.

Correction: Single-cell RNA-sequencing identifies anti-cancer immune phenotypes in the early lung metastatic niche during breast cancer.

Autor: Orbach SM; Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA., Brooks MD; Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA., Zhang Y; Department of Chemical Engineering, University of Michigan, Ann Arbor, MI, USA., Campit SE; Program in Chemical Biology, University of Michigan, Ann Arbor, MI, USA., Bushnell GG; Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA., Decker JT; Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA., Rebernick RJ; Medical Science Training Program, University of Michigan, Ann Arbor, MI, USA., Chandrasekaran S; Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA.; Program in Chemical Biology, University of Michigan, Ann Arbor, MI, USA.; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA.; Rogel Cancer Center, University of Michigan, Ann Arbor, MI, USA., Wicha MS; Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA.; Rogel Cancer Center, University of Michigan, Ann Arbor, MI, USA., Jeruss JS; Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA.; Rogel Cancer Center, University of Michigan, Ann Arbor, MI, USA.; Department of Surgery, University of Michigan, Ann Arbor, MI, USA.; Department of Pathology, University of Michigan, Ann Arbor, MI, USA., Shea LD; Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA. ldshea@umich.edu.; Department of Chemical Engineering, University of Michigan, Ann Arbor, MI, USA. ldshea@umich.edu.; Rogel Cancer Center, University of Michigan, Ann Arbor, MI, USA. ldshea@umich.edu.

Publikováno v: Clinical & experimental metastasis [Clin Exp Metastasis] 2023 Aug; Vol. 40 (4), pp. 373.

Myeloid cell reprogramming alleviates immunosuppression and promotes clearance of metastatic lesions.

Autor: Raghani RM; Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, United States., Ma JA; Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, United States., Zhang Y; Department of Chemical Engineering, University of Michigan, Ann Arbor, MI, United States., Orbach SM; Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, United States., Wang J; Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, United States., Zeinali M; Department of Chemical Engineering, University of Michigan, Ann Arbor, MI, United States., Nagrath S; Department of Chemical Engineering, University of Michigan, Ann Arbor, MI, United States., Kakade S; COUR Pharmaceuticals Development Co, Inc, Northbrook, IL, United States., Xu Q; COUR Pharmaceuticals Development Co, Inc, Northbrook, IL, United States., Podojil JR; COUR Pharmaceuticals Development Co, Inc, Northbrook, IL, United States.; Department of Microbiology-Immunology, Feinberg School of Medicine, Northwestern University, Chicago, IL, United States., Murthy T; COUR Pharmaceuticals Development Co, Inc, Northbrook, IL, United States., Elhofy A; COUR Pharmaceuticals Development Co, Inc, Northbrook, IL, United States., Jeruss JS; Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, United States.; Department of Surgery, University of Michigan, Ann Arbor, MI, United States.; Department of Pathology, University of Michigan, Ann Arbor, MI, United States., Shea LD; Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, United States.; Department of Chemical Engineering, University of Michigan, Ann Arbor, MI, United States.

Publikováno v: Frontiers in oncology [Front Oncol] 2022 Nov 21; Vol. 12, pp. 1039993. Date of Electronic Publication: 2022 Nov 21 (Print Publication: 2022).

Pancreatic cancer is marked by complement-high blood monocytes and tumor-associated macrophages.

Autor: Kemp SB; Departments of Molecular and Cellular Pathology, University of Michigan, Ann Arbor, MI, USA., Steele NG; Cell and Developmental Biology, University of Michigan, Ann Arbor, MI, USA., Carpenter ES; Internal Medicine, Division of Gastroenterology, University of Michigan, Ann Arbor, MI, USA., Donahue KL; Cancer Biology, University of Michigan, Ann Arbor, MI, USA., Bushnell GG; Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA., Morris AH; Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA., The S; Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA., Orbach SM; Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA., Sirihorachai VR; Cancer Biology, University of Michigan, Ann Arbor, MI, USA., Nwosu ZC; Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, USA., Espinoza C; Surgery, University of Michigan, Ann Arbor, MI, USA., Lima F; Surgery, University of Michigan, Ann Arbor, MI, USA., Brown K; Surgery, University of Michigan, Ann Arbor, MI, USA., Girgis AA; Surgery, University of Michigan, Ann Arbor, MI, USA., Gunchick V; Internal Medicine, Division of Hematology and Oncology, University of Michigan, Ann Arbor, MI, USA., Zhang Y; Surgery, University of Michigan, Ann Arbor, MI, USA., Lyssiotis CA; Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, USA.; Rogel Cancer Center, University of Michigan, Ann Arbor, MI, USA., Frankel TL; Surgery, University of Michigan, Ann Arbor, MI, USA.; Rogel Cancer Center, University of Michigan, Ann Arbor, MI, USA., Bednar F; Surgery, University of Michigan, Ann Arbor, MI, USA.; Rogel Cancer Center, University of Michigan, Ann Arbor, MI, USA., Rao A; Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA.; Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA.; Radiation Oncology, University of Michigan, Ann Arbor, MI, USA.; Biostatistics, University of Michigan, Ann Arbor, MI, USA.; Rogel Cancer Center, University of Michigan, Ann Arbor, MI, USA., Sahai V; Internal Medicine, Division of Hematology and Oncology, University of Michigan, Ann Arbor, MI, USA., Shea LD; Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA., Crawford HC; Cancer Biology, University of Michigan, Ann Arbor, MI, USA hcrawfo1@hfhs.org.; Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, USA.; Rogel Cancer Center, University of Michigan, Ann Arbor, MI, USA., Pasca di Magliano M; Cell and Developmental Biology, University of Michigan, Ann Arbor, MI, USA marinapa@umich.edu.; Cancer Biology, University of Michigan, Ann Arbor, MI, USA.; Surgery, University of Michigan, Ann Arbor, MI, USA.; Rogel Cancer Center, University of Michigan, Ann Arbor, MI, USA.

Publikováno v: Life science alliance [Life Sci Alliance] 2021 Mar 29; Vol. 4 (6). Date of Electronic Publication: 2021 Mar 29 (Print Publication: 2021).