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TSPY potentiates cell proliferation and tumorigenesis by promoting cell cycle progression in HeLa and NIH3T3 cells

Autor: Chan Wai-Yee, Lee Tin-Lap, Liu Xing, Oram Shane W, Lau Yun-Fai

Publikováno v: BMC Cancer, Vol 6, Iss 1, p 154 (2006)

Abstract Background TSPY is a repeated gene mapped to the critical region harboring the gonadoblastoma locus on the Y chromosome (GBY), the only oncogenic locus on this male-specific chromosome. Elevated levels of TSPY have been observed in gonadobla

Externí odkaz: https://doaj.org/article/73ec03dc45e948688f1e9f2d0921021c

Acute promyelocytic leukaemia lying under the mask of COVID-19-a diagnostic and therapeutic conundrum.

Autor: Farmer I; Department of Haematology, Lewisham and Greenwich NHS Trust, London, UK., Okikiolu J; Department of Haematology, Lewisham and Greenwich NHS Trust, London, UK., Steel M; Department of Haematology, Lewisham and Greenwich NHS Trust, London, UK., Wanniarachchi C; Department of Haematology, Lewisham and Greenwich NHS Trust, London, UK., Littlewood S; Department of Haematology, Lewisham and Greenwich NHS Trust, London, UK., Gupta S; Department of Haematology, Lewisham and Greenwich NHS Trust, London, UK., Thanigaikumar M; Department of Haematology, Lewisham and Greenwich NHS Trust, London, UK., Oram SH; Department of Haematology, Lewisham and Greenwich NHS Trust, London, UK., Moonim M; Department of Histopathology, Guys and St Thomas NHS Foundation Trust, London, UK., Kulasekararaj AG; Department of Haematological Medicine, King's College Hospital, London, UK., Yeghen T; Department of Haematology, Lewisham and Greenwich NHS Trust, London, UK.

Publikováno v: British journal of haematology [Br J Haematol] 2020 Aug; Vol. 190 (4), pp. e248-e250. Date of Electronic Publication: 2020 Jun 08.

ERG promotes T-acute lymphoblastic leukemia and is transcriptionally regulated in leukemic cells by a stem cell enhancer.

Autor: Thoms JA; Lowy Cancer Research Centre and the Prince of Wales Clinical School, University of New South Wales, Sydney, Australia., Birger Y, Foster S, Knezevic K, Kirschenbaum Y, Chandrakanthan V, Jonquieres G, Spensberger D, Wong JW, Oram SH, Kinston SJ, Groner Y, Lock R, MacKenzie KL, Göttgens B, Izraeli S, Pimanda JE

Publikováno v: Blood [Blood] 2011 Jun 30; Vol. 117 (26), pp. 7079-89. Date of Electronic Publication: 2011 May 02.

A previously unrecognized promoter of LMO2 forms part of a transcriptional regulatory circuit mediating LMO2 expression in a subset of T-acute lymphoblastic leukaemia patients.

Autor: Oram SH; Department of Haematology, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK., Thoms JA, Pridans C, Janes ME, Kinston SJ, Anand S, Landry JR, Lock RB, Jayaraman PS, Huntly BJ, Pimanda JE, Göttgens B

Publikováno v: Oncogene [Oncogene] 2010 Oct 28; Vol. 29 (43), pp. 5796-808. Date of Electronic Publication: 2010 Aug 02.