Zobrazeno 1 - 10
of 134
pro vyhledávání: '"Ora A Weisz"'
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e86425 (2014)
Epithelial cells elaborate specialized domains that have distinct protein and lipid compositions, including the apical and basolateral surfaces and primary cilia. Maintaining the identity of these domains is required for proper cell function, and req
Externí odkaz:
https://doaj.org/article/48f0398829cf46cd94d36ae06919cb26
Autor:
Irina L. Tourkova, Quitterie C. Larrouture, Silvia Liu, Jianhua Luo, Katherine E. Shipman, Kelechi M. Onwuka, Ora A. Weisz, Vladimir Riazanski, Deborah J. Nelson, Matthew L. MacDonald, Paul H. Schlesinger, Harry C. Blair
Publikováno v:
Bone Reports, Vol 21, Iss , Pp 101763- (2024)
Acid transport is required for bone synthesis by osteoblasts. The osteoblast basolateral surface extrudes acid by Na+/H+ exchange, but apical proton uptake is undefined. We found high expression of the Cl−/H+ exchanger ClC3 at the bone apical surfa
Externí odkaz:
https://doaj.org/article/bf7bf14d1982441993e7c2bea477f974
Publikováno v:
Frontiers in Physiology, Vol 15 (2024)
Proximal tubule (PT) cells maintain a high-capacity apical endocytic pathway to recover essentially all proteins that escape the glomerular filtration barrier. The multi ligand receptors megalin and cubilin play pivotal roles in the endocytic uptake
Externí odkaz:
https://doaj.org/article/6b94c10a7dd042539ac83512d59ec578
Autor:
Christina M Szalinski, Christopher J Guerriero, Wily G Ruiz, Brianne E Docter, Youssef Rbaibi, Núria M Pastor-Soler, Gerard Apodaca, Manojkumar A Puthenveedu, Ora A Weisz
Publikováno v:
PLoS ONE, Vol 8, Iss 1, p e53790 (2013)
Localized synthesis of phosphatidylinositol 4,5-bisphosphate [PtdIns(4,5)P(2)] at clathrin coated pits (CCPs) is crucial for the recruitment of adaptors and other components of the internalization machinery, as well as for regulating actin dynamics d
Externí odkaz:
https://doaj.org/article/875ca782e48b4344a81acae0687ed123
Publikováno v:
PLoS ONE, Vol 4, Iss 8, p e6551 (2009)
Retroviral Gag polyproteins are necessary and sufficient for virus budding. Productive HIV-1 Gag assembly takes place at the plasma membrane. However, little is known about the mechanisms by which thousands of Gag molecules are targeted to the plasma
Externí odkaz:
https://doaj.org/article/16867a239da1467ea7634b34c77bc12d
Autor:
Markus M. Rinschen, Oleg Palygin, Ashraf El-Meanawy, Xavier Domingo-Almenara, Amelia Palermo, Lashodya V. Dissanayake, Daria Golosova, Michael A. Schafroth, Carlos Guijas, Fatih Demir, Johannes Jaegers, Megan L. Gliozzi, Jingchuan Xue, Martin Hoehne, Thomas Benzing, Bernard P. Kok, Enrique Saez, Markus Bleich, Nina Himmerkus, Ora A. Weisz, Benjamin F. Cravatt, Marcus Krüger, H. Paul Benton, Gary Siuzdak, Alexander Staruschenko
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Kidney metabolism in disease is important but not well understood. Here, using isotope-guided metabolomics, the authors show that lysine’s metabolic activity conveys kidney protection in hypertension through accelerated metabolism and physiological
Externí odkaz:
https://doaj.org/article/2e9849a398d242b7a32232ec6d46f7d8
Autor:
Katherine E. Shipman, Catherine J. Baty, Kimberly R. Long, Youssef Rbaibi, Isabella A. Cowan, Mona Gerges, Allison L. Marciszyn, Ossama B. Kashlan, Roderick J. Tan, Aurélie Edwards, Ora A. Weisz
Publikováno v:
Journal of the American Society of Nephrology. 34:619-640
Autor:
Youssef Rbaibi, Kimberly R. Long, Katherine E. Shipman, Qidong Ren, Catherine J. Baty, Ossama B. Kashlan, Ora A. Weisz
Publikováno v:
Molecular Biology of the Cell. 34
CRISPR/Cas9 approaches were used to generate megalin, cubilin, and Dab2 knockouts in polarized proximal tubule cells. Knockout of each component had different effects on endocytic uptake. Data from cell lines and megalin knockout mice support a novel
Publikováno v:
Journal of Clinical and Translational Science, Vol 3, Pp 12-13 (2019)
OBJECTIVES/SPECIFIC AIMS: While Hb-induced toxicity has been assumed to cause PT dysfunction, the development of tubular proteinuria from this dysfunction in SCD patients is not well understood. We previously found that free Hb, at concentrations pre
Externí odkaz:
https://doaj.org/article/e582129988344eaaa159b789b0ec90fe
Autor:
Elynna B. Youm, Wafaa N. Albalawy, Kimberly R. Long, Youssef Rbaibi, Katherine E. Shipman, Catherine J. Baty, Ora A. Weisz
Publikováno v:
The FASEB Journal. 36