Zobrazeno 1 - 10
of 13 301
pro vyhledávání: '"Ora A"'
Autor:
Irina L. Tourkova, Quitterie C. Larrouture, Silvia Liu, Jianhua Luo, Katherine E. Shipman, Kelechi M. Onwuka, Ora A. Weisz, Vladimir Riazanski, Deborah J. Nelson, Matthew L. MacDonald, Paul H. Schlesinger, Harry C. Blair
Publikováno v:
Bone Reports, Vol 21, Iss , Pp 101763- (2024)
Acid transport is required for bone synthesis by osteoblasts. The osteoblast basolateral surface extrudes acid by Na+/H+ exchange, but apical proton uptake is undefined. We found high expression of the Cl−/H+ exchanger ClC3 at the bone apical surfa
Externí odkaz:
https://doaj.org/article/bf7bf14d1982441993e7c2bea477f974
Publikováno v:
Frontiers in Physiology, Vol 15 (2024)
Proximal tubule (PT) cells maintain a high-capacity apical endocytic pathway to recover essentially all proteins that escape the glomerular filtration barrier. The multi ligand receptors megalin and cubilin play pivotal roles in the endocytic uptake
Externí odkaz:
https://doaj.org/article/6b94c10a7dd042539ac83512d59ec578
Autor:
Markus M. Rinschen, Oleg Palygin, Ashraf El-Meanawy, Xavier Domingo-Almenara, Amelia Palermo, Lashodya V. Dissanayake, Daria Golosova, Michael A. Schafroth, Carlos Guijas, Fatih Demir, Johannes Jaegers, Megan L. Gliozzi, Jingchuan Xue, Martin Hoehne, Thomas Benzing, Bernard P. Kok, Enrique Saez, Markus Bleich, Nina Himmerkus, Ora A. Weisz, Benjamin F. Cravatt, Marcus Krüger, H. Paul Benton, Gary Siuzdak, Alexander Staruschenko
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Kidney metabolism in disease is important but not well understood. Here, using isotope-guided metabolomics, the authors show that lysine’s metabolic activity conveys kidney protection in hypertension through accelerated metabolism and physiological
Externí odkaz:
https://doaj.org/article/2e9849a398d242b7a32232ec6d46f7d8
One of the main advantages of deep learning models of protein structure, such as Alphafold2, is their ability to accurately estimate the confidence of a generated structural model, which allows us to focus on highly confident predictions.The ipTM sco
Externí odkaz:
http://arxiv.org/abs/2412.15970
Autor:
Roy, Anand, Eyal, Anna, Skiff, Roni Majlin, Barick, Barun, Escribano, Samuel D., Brontvein, Olga, Rechav, Katya, Bitton, Ora, Ilan, Roni, Joselevich, Ernesto
Nanowires (NWs) of topological materials are emerging as an exciting platform to probe and engineer new quantum phenomena that are hard to access in bulk phase. Their quasi-one-dimensional geometry and large surface-to-bulk ratio unlock new expressio
Externí odkaz:
http://arxiv.org/abs/2411.15974
Autor:
Kour, George, Zwerdling, Naama, Zalmanovici, Marcel, Anaby-Tavor, Ateret, Fandina, Ora Nova, Farchi, Eitan
Large language models (LLMs) are increasingly used in business dialogue systems but they pose security and ethical risks. Multi-turn conversations, where context influences the model's behavior, can be exploited to produce undesired responses. In thi
Externí odkaz:
http://arxiv.org/abs/2409.04822
Probabilistic metric embedding into trees is a powerful technique for designing online algorithms. The standard approach is to embed the entire underlying metric into a tree metric and then solve the problem on the latter. The overhead in the competi
Externí odkaz:
http://arxiv.org/abs/2408.16298
Consider a scenario where a harmfulness detection metric is employed by a system to filter unsafe responses generated by a Large Language Model. When analyzing individual harmful and unethical prompt-response pairs, the metric correctly classifies ea
Externí odkaz:
http://arxiv.org/abs/2408.12259
Autor:
Ohana, Tal Shahar, Guendelman, Gabriel, Mishuk, Eran, Kandel, Nadav, Garti, Dror, Gurevich, Doron, Bitton, Ora, Dayan, Barak
Of the many applications of whispering-gallery mode (WGM) microresonators, Single-atom cavity-QED poses the most extreme demands on mode-volume and quality factor. Here we present a model-based procedure for the fabrication of small mode-volume ultra
Externí odkaz:
http://arxiv.org/abs/2408.08257
Autor:
Hyun Jung Park, Zhenjiang Fan, Yulong Bai, Qidong Ren, Youssef Rbaibi, Kimberly R. Long, Megan L. Gliozzi, Natalie Rittenhouse, Joseph D. Locker, Amanda C. Poholek, Ora A. Weisz
Publikováno v:
Frontiers in Physiology, Vol 11 (2020)
Cultured cell models are an essential complement to dissecting kidney proximal tubule (PT) function in health and disease but do not fully recapitulate key features of this nephron segment. We recently determined that culture of opossum kidney (OK) c
Externí odkaz:
https://doaj.org/article/13f16484c8434e7fb674bdf16f980481