Zobrazeno 1 - 10
of 4 744
pro vyhledávání: '"Or Gozani"'
Autor:
Alexandre G. Casanova, Gael S. Roth, Simone Hausmann, Xiaoyin Lu, Ludivine J. M. Bischoff, Emilie M. Froeliger, Lucid Belmudes, Ekaterina Bourova-Flin, Natasha M. Flores, Ana Morales Benitez, Tourkian Chasan, Marcello Caporicci, Jessica Vayr, Sandrine Blanchet, Francesco Ielasi, Sophie Rousseaux, Pierre Hainaut, Or Gozani, Muriel Le Romancer, Yohann Couté, Andres Palencia, Pawel K. Mazur, Nicolas Reynoird
Publikováno v:
Cell Discovery, Vol 10, Iss 1, Pp 1-3 (2024)
Externí odkaz:
https://doaj.org/article/47e63f5c6a3744d6b26f87923884effe
Autor:
Alexandre G. Casanova, Gael S. Roth, Simone Hausmann, Xiaoyin Lu, Ludivine J. M. Bischoff, Emilie M. Froeliger, Lucid Belmudes, Ekaterina Bourova-Flin, Natasha M. Flores, Ana Morales Benitez, Tourkian Chasan, Marcello Caporicci, Jessica Vayr, Sandrine Blanchet, Francesco Ielasi, Sophie Rousseaux, Pierre Hainaut, Or Gozani, Muriel Le Romancer, Yohann Couté, Andres Palencia, Pawel K. Mazur, Nicolas Reynoird
Publikováno v:
Cell Discovery, Vol 10, Iss 1, Pp 1-22 (2024)
Abstract Malignant forms of breast cancer refractory to existing therapies remain a major unmet health issue, primarily due to metastatic spread. A better understanding of the mechanisms at play will provide better insights for alternative treatments
Externí odkaz:
https://doaj.org/article/077613e1385a431ba433f5e87d531e0f
Autor:
Christine E. Peters, Ursula Schulze-Gahmen, Manon Eckhardt, Gwendolyn M. Jang, Jiewei Xu, Ernst H. Pulido, Conner Bardine, Charles S. Craik, Melanie Ott, Or Gozani, Kliment A. Verba, Ruth Hüttenhain, Jan E. Carette, Nevan J. Krogan
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Actin histidine methyltransferase SETD3 is a host factor critical for the replication of enteroviruses. Here, the authors report the 3.5 Å cryoEM structure of SETD3 interacting with enterovirus CV-B3 2A protease, defining the actin-binding SET domai
Externí odkaz:
https://doaj.org/article/22221195d9174bdcb9744f12954ad8ae
Autor:
Wendan Ren, Huitao Fan, Sara A. Grimm, Jae Jin Kim, Linhui Li, Yiran Guo, Christopher James Petell, Xiao-Feng Tan, Zhi-Min Zhang, John P. Coan, Jiekai Yin, Dae In Kim, Linfeng Gao, Ling Cai, Nelli Khudaverdyan, Burak Çetin, Dinshaw J. Patel, Yinsheng Wang, Qiang Cui, Brian D. Strahl, Or Gozani, Kyle M. Miller, Seán E. O’Leary, Paul A. Wade, Gang Greg Wang, Jikui Song
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
How histone modifications crosstalk with DNA methylation to regulate epigenomic patterning and genome stability in mammals remains elusive. Here, the authors show that DNA methyltransferase DNMT1 is a reader for histone H4K20 trimethylation via its B
Externí odkaz:
https://doaj.org/article/a3cd3e4f8bb144c1bf23822e78c3db7f
Autor:
Shaobo Dai, John R. Horton, Clayton B. Woodcock, Alex W. Wilkinson, Xing Zhang, Or Gozani, Xiaodong Cheng
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-8 (2019)
SETD3 is the first known metazoan protein histidine methyltransferase but the molecular basis for its target specificity is unclear. Here, the authors elucidate the structural and molecular determinants for the histidine specificity of SETD3.
Externí odkaz:
https://doaj.org/article/f2129526184a4597af28ea92c757a4b4
Autor:
Saumya M. Sankaran, Or Gozani
Publikováno v:
Epigenetics, Vol 12, Iss 11, Pp 917-922 (2017)
Recurrent mutations at key lysine residues in the histone variant H3.3 are thought to play an etiologic role in the development of distinct subsets of pediatric gliomas and bone and cartilage cancers. H3.3K36M is one such mutation that was originally
Externí odkaz:
https://doaj.org/article/2d56ae4ed9f147d481409d59cc405e84
Autor:
Shilpi Paul, Alex Kuo, Thomas Schalch, Hannes Vogel, Leemor Joshua-Tor, W. Richard McCombie, Or Gozani, Molly Hammell, Alea A. Mills
Publikováno v:
Cell Reports, Vol 3, Iss 1, Pp 92-102 (2013)
Chromodomain Helicase DNA binding protein 5 (CHD5) is a tumor suppressor mapping to 1p36, a genomic region that is frequently deleted in human cancer. Although CHD5 belongs to the CHD family of chromatin-remodeling proteins, whether its tumor-suppres
Externí odkaz:
https://doaj.org/article/f9f090b80e5b4e65afec1a6812c2e2d9
Autor:
Dennis J Bua, Alex J Kuo, Peggie Cheung, Chih Long Liu, Valentina Migliori, Alexsandra Espejo, Fabio Casadio, Christian Bassi, Bruno Amati, Mark T Bedford, Ernesto Guccione, Or Gozani
Publikováno v:
PLoS ONE, Vol 4, Iss 8, p e6789 (2009)
Knowledge of protein domains that function as the biological effectors for diverse post-translational modifications of histones is critical for understanding how nuclear and epigenetic programs are established. Indeed, mutations of chromatin effector
Externí odkaz:
https://doaj.org/article/2d281c9f5c1d4d988c54080c8fdf2b29
Autor:
Gray, Zach H., Chakraborty, Damayanti, Duttweiler, Reuben R., Alekbaeva, Gulnaz D., Murphy, Sedona E., Chetal, Kashish, Ji, Fei, Ferman, Benjamin I., Honer, Madison A., Wang, Zhentian, Myers, Cynthia, Sun, Renhong, Kaniskan, H. Ümit, Toma, Monika Maria, Bondarenko, Elena A., Santoro, John N., Miranda, Christopher, Dillingham, Megan E., Tang, Ran, Gozani, Or, Jin, Jian, Skorski, Tomasz, Duy, Cihangir, Lee, Hayan, Sadreyev, Ruslan I., Whetstine, Johnathan R.
Publikováno v:
In Cell 12 October 2023 186(21):4528-4545
Autor:
Francis, Joel William, Shao, Zengyu, Narkhede, Pradnya, Trinh, Annie Truc, Lu, Jiuwei, Song, Jikui, Gozani, Or
Publikováno v:
In Journal of Biological Chemistry July 2023 299(7)