Zobrazeno 1 - 10
of 1 022
pro vyhledávání: '"Optn"'
Autor:
Haitian Nan, Yeon-Jeong Kim, Min Chu, Dan Li, Jieying Li, Deming Jiang, Yiming Wu, Toshihisa Ohtsuka, Liyong Wu
Publikováno v:
Alzheimer’s Research & Therapy, Vol 16, Iss 1, Pp 1-24 (2024)
Abstract Background Our study aims to evaluate the genetic and phenotypic spectrum of Frontotemporal dementia (FTD) gene variant carriers in Chinese populations, investigate mutation frequencies, and assess the functional properties of TBK1 and OPTN
Externí odkaz:
https://doaj.org/article/90adb931fafc4c478550548d8c52986b
Publikováno v:
Acta Biochimica et Biophysica Sinica, Vol 56, Pp 1044-1054 (2024)
Esophagus cancer (EC) is one of the most aggressive malignant digestive system tumors and has a high clinical incidence worldwide. Magnolol, a natural compound, has anticancer effects on many cancers, including esophageal carcinoma, but the underlyin
Externí odkaz:
https://doaj.org/article/62b676effefa43cbb7185bf8bd2c7e29
Autor:
Caixia Zang, Hui Liu, Jingwen Ning, Qiuzhu Chen, Yueqi Jiang, Meiyu Shang, Yang Yang, Jingwei Ma, Yirong Dong, Jinrong Wang, Fangfang Li, Xiuqi Bao, Dan Zhang
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 172, Iss , Pp 116204- (2024)
HACE1 is a member of the HECT domain-containing E3 ligases with 909 amino acid residues, containing N-terminal ankyrin-repeats (ANK) and C-terminal HECT domain. Previously, it was shown that HACE1 is inactive in human tumors and plays a crucial role
Externí odkaz:
https://doaj.org/article/bc0afd4978f6487ab0d05790511664be
Autor:
Islam B. Mohamed, Mohamed Saleh Ismail, Ahmed El Sabagh, Ahmed M. Afifi Abdelwahab, Efstathia Polychronopoulou, Yong‐Fang Kuo, Manal Hassan, John A. Goss, Fasiha Kanwal, Prasun K. Jalal
Publikováno v:
Cancer Medicine, Vol 12, Iss 14, Pp 15011-15025 (2023)
Abstract Background and Aims Contrast‐enhanced cross‐sectional imaging is the cornerstone in the diagnosis, staging, and management of HCC, including eligibility for liver transplantation (LT). Radiological‐histopathological discordance may lea
Externí odkaz:
https://doaj.org/article/46650fe03cdc415e9525153a4d7a7730
Autor:
Yang Pan, Takeshi Iwata
Publikováno v:
Indian Journal of Ophthalmology, Vol 72, Iss Suppl 3, Pp S335-S344 (2024)
Normal tension glaucoma (NTG) is a complex optic neuropathy characterized by progressive retinal ganglion cell death and glaucomatous visual field loss, despite normal intraocular pressure (IOP). This condition poses a unique clinical challenge due t
Externí odkaz:
https://doaj.org/article/595765c1d3594626b2168ada851e19ff
Autor:
Jiajun Xie, Annemarie H. Meijer
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 13 (2024)
Anti-bacterial autophagy, also known as xenophagy, is a crucial innate immune process that helps maintain cellular homeostasis by targeting invading microbes. This defense pathway is widely studied in the context of infections with mycobacteria, the
Externí odkaz:
https://doaj.org/article/91e019a4e76e46c2994b5be1c4651793
Publikováno v:
mBio, Vol 14, Iss 6 (2023)
ABSTRACTTank-binding kinase 1 (TBK1) plays a pivotal role as a cellular factor in regulating the immune response against herpes simplex virus type 1 (HSV-1). TBK1’s role in defending against HSV-1 is attributed to its capacity to induce the type I
Externí odkaz:
https://doaj.org/article/a9a62baf4084410c9ef74c7a11451771
Publikováno v:
Frontiers in Medicine, Vol 10 (2023)
Glaucoma is the second leading cause of irreversible blindness worldwide. Although genetic background contributes differently to rare early-onset glaucoma (before age 40) or common adult-onset glaucoma, it is now considered an important factor in all
Externí odkaz:
https://doaj.org/article/93f4ccd75b53449e9fba876fcbd5741f
Gefitinib facilitates PINK1/Parkin-mediated mitophagy by enhancing mitochondrial recruitment of OPTN
Autor:
Ningning Li, Shan Sun, Guoqiang Ma, Hongyu Hou, Qilian Ma, Li Zhang, Zengli Zhang, Hongfeng Wang, Zheng Ying
Publikováno v:
Fundamental Research, Vol 2, Iss 5, Pp 807-816 (2022)
Gefitinib, a well-known epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor for the targeted therapy of lung cancer, induces autophagy in association with drug resistance. However, it remains unclear whether gefitinib treatment can affe
Externí odkaz:
https://doaj.org/article/2fafca36576142b18274ba4e6e1dad1f
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