Evaluation of Retinal Structure and Visual Function in Blue Cone Monochromacy to Develop Clinical Endpoints for L-opsin Gene Therapy.

Autor: Cideciyan AV; Scheie Eye Institute, Department of Ophthalmology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Roman AJ; Scheie Eye Institute, Department of Ophthalmology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Warner RL; Scheie Eye Institute, Department of Ophthalmology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Sumaroka A; Scheie Eye Institute, Department of Ophthalmology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Wu V; Scheie Eye Institute, Department of Ophthalmology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Jiang YY; Scheie Eye Institute, Department of Ophthalmology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Swider M; Scheie Eye Institute, Department of Ophthalmology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Garafalo AV; Scheie Eye Institute, Department of Ophthalmology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Viarbitskaya I; Scheie Eye Institute, Department of Ophthalmology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Russell RC; Scheie Eye Institute, Department of Ophthalmology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Kohl S; Molecular Genetics Laboratory, Centre for Ophthalmology, University of Tübingen, D-72076 Tübingen, Germany., Wissinger B; Molecular Genetics Laboratory, Centre for Ophthalmology, University of Tübingen, D-72076 Tübingen, Germany., Ripamonti C; Cambridge Research Systems, Rochester ME2 4BH, UK., Barbur JL; Centre for Applied Vision Research, School of Health & Psychological Sciences, City St. George's, University of London, London EC1V 0HB, UK., Bach M; Eye Center, Medical Center-Faculty of Medicine, University of Freiburg, D-79106 Freiburg, Germany., Carroll J; Departments of Ophthalmology & Visual Science, Cell Biology, Neurobiology, and Anatomy, Medical College of Wisconsin, Milwaukee, WI 53226, USA., Morgan JIW; Scheie Eye Institute, Department of Ophthalmology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Aleman TS; Scheie Eye Institute, Department of Ophthalmology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

Publikováno v: International journal of molecular sciences [Int J Mol Sci] 2024 Oct 02; Vol. 25 (19). Date of Electronic Publication: 2024 Oct 02.

Multiple Ecological Axes Drive Molecular Evolution of Cone Opsins in Beloniform Fishes.

Autor: Chau KD; Department of Physical & Environmental Sciences, University of Toronto Scarborough, Toronto, ON, Canada.; Department of Biological Sciences, University of Toronto Scarborough, Toronto, ON, Canada.; Department of Biology, York University, Toronto, ON, Canada., Hauser FE; Department of Biological Sciences, University of Toronto Scarborough, Toronto, ON, Canada., Van Nynatten A; Department of Biological Sciences, University of Toronto Scarborough, Toronto, ON, Canada.; Department of Biology, University of Victoria, Victoria, Canada., Daane JM; Department of Biology and Biochemistry, University of Houston, Houston, TX, USA., Harris MP; Department of Genetics, Harvard Medical School, Boston, MA, USA., Chang BSW; Department of Ecology and Evolutionary Biology, University of Toronto, Toronto, ON, Canada.; Department of Cell and Systems Biology, University of Toronto, Toronto, ON, Canada., Lovejoy NR; Department of Physical & Environmental Sciences, University of Toronto Scarborough, Toronto, ON, Canada. nathan.lovejoy@utoronto.ca.; Department of Biological Sciences, University of Toronto Scarborough, Toronto, ON, Canada. nathan.lovejoy@utoronto.ca.; Department of Ecology and Evolutionary Biology, University of Toronto, Toronto, ON, Canada. nathan.lovejoy@utoronto.ca.; Department of Cell and Systems Biology, University of Toronto, Toronto, ON, Canada. nathan.lovejoy@utoronto.ca.

Publikováno v: Journal of molecular evolution [J Mol Evol] 2024 Apr; Vol. 92 (2), pp. 93-103. Date of Electronic Publication: 2024 Feb 28.

Selection on Visual Opsin Genes in Diurnal Neotropical Frogs and Loss of the SWS2 Opsin in Poison Frogs.

Autor: Wan YC; Museum of Vertebrate Zoology and Department of Integrative Biology, University of California Berkeley, Berkeley, CA, USA.; Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.; School of Biomolecular and Biomedical Science, University College Dublin, Belfield, Dublin, Ireland., Navarrete Méndez MJ; Museum of Vertebrate Zoology and Department of Integrative Biology, University of California Berkeley, Berkeley, CA, USA.; Museo de Zoología, Facultad de Ciencias Exactas y Naturales, Pontificia Universidad Católica del Ecuador, Quito, Ecuador., O'Connell LA; Department of Biology, Stanford University, Palo Alto, CA, USA., Uricchio LH; Museum of Vertebrate Zoology and Department of Integrative Biology, University of California Berkeley, Berkeley, CA, USA.; Department of Biology, Tufts University, Medford, MA, USA., Roland AB; FAS Center for Systems Biology, Harvard University, Cambridge, MA, USA.; Research Centre on Animal Cognition (CRCA), Centre for Integrative Biology (CBI), UMR5169 CNRS, Toulouse University, Toulouse, France., Maan ME; Groningen Institute for Evolutionary Life Sciences, University of Groningen, Groningen, The Netherlands., Ron SR; Museo de Zoología, Facultad de Ciencias Exactas y Naturales, Pontificia Universidad Católica del Ecuador, Quito, Ecuador., Betancourth-Cundar M; Departamento de Ciencias Biológicas, Universidad de los Andes, Bogotá, Colombia., Pie MR; Department of Zoology, Universidade Federal do Paraná, Curitiba, Brazil.; Biology Department, Edge Hill University, Ormskirk, United Kingdom., Howell KA; Department of Biological Sciences, University of Pittsburgh, Pittsburgh, PA, USA., Richards-Zawacki CL; Department of Biological Sciences, University of Pittsburgh, Pittsburgh, PA, USA., Cummings ME; Department of Integrative Biology, University of Texas at Austin, Austin, TX, USA., Cannatella DC; Department of Integrative Biology, University of Texas at Austin, Austin, TX, USA.; Biodiversity Center, University of Texas at Austin, Austin, TX, USA., Santos JC; Department of Biological Sciences, St. John's University, New York City, NY, USA., Tarvin RD; Museum of Vertebrate Zoology and Department of Integrative Biology, University of California Berkeley, Berkeley, CA, USA.

Publikováno v: Molecular biology and evolution [Mol Biol Evol] 2023 Oct 04; Vol. 40 (10).

Preclinical evaluation of ADVM-062, a novel intravitreal gene therapy vector for the treatment of blue cone monochromacy.

Autor: Hanna K; Adverum Biotechnologies, Inc., Redwood City, CA 94063, USA., Nieves J; Adverum Biotechnologies, Inc., Redwood City, CA 94063, USA., Dowd C; Adverum Biotechnologies, Inc., Redwood City, CA 94063, USA., Bender KO; Adverum Biotechnologies, Inc., Redwood City, CA 94063, USA., Sharma P; Adverum Biotechnologies, Inc., Redwood City, CA 94063, USA., Singh B; Adverum Biotechnologies, Inc., Redwood City, CA 94063, USA., Renz M; Adverum Biotechnologies, Inc., Redwood City, CA 94063, USA., Ver Hoeve JN; Ocular Services on Demand (OSOD), Madison, WI 53719, USA., Cepeda D; Adverum Biotechnologies, Inc., Redwood City, CA 94063, USA., Gelfman CM; Adverum Biotechnologies, Inc., Redwood City, CA 94063, USA., Riley BE; Adverum Biotechnologies, Inc., Redwood City, CA 94063, USA. Electronic address: briley@adverum.com., Grishanin RN; Adverum Biotechnologies, Inc., Redwood City, CA 94063, USA. Electronic address: rgrishanin@adverum.com.

Publikováno v: Molecular therapy : the journal of the American Society of Gene Therapy [Mol Ther] 2023 Jul 05; Vol. 31 (7), pp. 2014-2027. Date of Electronic Publication: 2023 Mar 16.

Active state structures of a bistable visual opsin bound to G proteins.

Autor: Tejero O; Laboratory of Biomolecular Research, PSI Center for Life Sciences, Villigen-PSI, Switzerland.; Department of Biology, ETH Zurich, Zurich, Switzerland., Pamula F; Laboratory of Biomolecular Research, PSI Center for Life Sciences, Villigen-PSI, Switzerland.; Department of Molecular Biology and Genetics, Aarhus University, Aarhus, Denmark., Koyanagi M; Department of Biology, Graduate School of Science, Osaka Metropolitan University, Osaka, Japan.; The OMU Advanced Research Institute of Natural Science and Technology, Osaka Metropolitan University, Osaka, Japan., Nagata T; Department of Biology and Geosciences, Graduate School of Science, Osaka City University, Osaka, Japan.; Institute for Solid State Physics, The University of Tokyo, Kashiwa, Chiba, Japan., Afanasyev P; Cryo-EM Knowledge Hub, ETH Zurich, Zurich, Switzerland., Das I; Department of Molecular Chemistry and Materials Science, Weizmann Institute of Science, Rehovot, Israel., Deupi X; Laboratory of Biomolecular Research, PSI Center for Life Sciences, Villigen-PSI, Switzerland.; Condensed Matter Theory Group, Laboratory of Theoretical and Computational Physics, PSI Center for Scientific Computing, Theory and Data, Villigen-PSI, Switzerland.; Swiss Institute of Bioinformatics, Lausanne, Switzerland., Sheves M; Department of Molecular Chemistry and Materials Science, Weizmann Institute of Science, Rehovot, Israel., Terakita A; Department of Biology, Graduate School of Science, Osaka Metropolitan University, Osaka, Japan.; The OMU Advanced Research Institute of Natural Science and Technology, Osaka Metropolitan University, Osaka, Japan., Schertler GFX; Laboratory of Biomolecular Research, PSI Center for Life Sciences, Villigen-PSI, Switzerland. gebhard.schertler@psi.ch., Rodrigues MJ; Laboratory of Biomolecular Research, PSI Center for Life Sciences, Villigen-PSI, Switzerland. matthew.rodrigues@psi.ch., Tsai CJ; Laboratory of Biomolecular Research, PSI Center for Life Sciences, Villigen-PSI, Switzerland. ching-ju.tsai@psi.ch.

Publikováno v: Nature communications [Nat Commun] 2024 Oct 16; Vol. 15 (1), pp. 8928. Date of Electronic Publication: 2024 Oct 16.