Predictive modeling provides insight into the clinical heterogeneity associated with TARS1 loss-of-function mutations.

Autor: Meyer-Schuman R; Department of Human Genetics, University of Michigan, Ann Arbor, Michigan, USA., Cale AR; Department of Human Genetics, University of Michigan, Ann Arbor, Michigan, USA., Pierluissi JA; Department of Human Genetics, University of Michigan, Ann Arbor, Michigan, USA., Jonatzke KE; Department of Human Genetics, University of Michigan, Ann Arbor, Michigan, USA., Park YN; Department of Human Genetics, University of Michigan, Ann Arbor, Michigan, USA., Lenk GM; Department of Human Genetics, University of Michigan, Ann Arbor, Michigan, USA., Oprescu SN; Department of Human Genetics, University of Michigan, Ann Arbor, Michigan, USA., Grachtchouk MA; Department of Dermatology, University of Michigan, Ann Arbor, MI, USA., Dlugosz AA; Department of Dermatology, University of Michigan, Ann Arbor, MI, USA.; Rogel Cancer Center, University of Michigan, Ann Arbor, MI, USA.; Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, MI, USA., Beg AA; Neuroscience Graduate Program, University of Michigan, Ann Arbor, MI, USA., Meisler MH; Department of Human Genetics, University of Michigan, Ann Arbor, Michigan, USA.; Department of Neurology, University of Michigan, Ann Arbor, MI, USA., Antonellis A; Department of Human Genetics, University of Michigan, Ann Arbor, Michigan, USA.; Department of Neurology, University of Michigan, Ann Arbor, MI, USA.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2024 Mar 27. Date of Electronic Publication: 2024 Mar 27.

PRMT5 mediates FoxO1 methylation and subcellular localization to regulate lipophagy in myogenic progenitors.

Autor: Kim KH; Department of Animal Sciences, Purdue University, West Lafayette, IN 47907, USA., Oprescu SN; Department of Animal Sciences, Purdue University, West Lafayette, IN 47907, USA; Department of Biological Sciences, Purdue University, West Lafayette, IN 47907, USA., Snyder MM; Department of Animal Sciences, Purdue University, West Lafayette, IN 47907, USA; Department of Biological Sciences, Purdue University, West Lafayette, IN 47907, USA., Kim A; Department of Pharmacy, Purdue University, West Lafayette, IN 47907, USA., Jia Z; Department of Animal Sciences, Purdue University, West Lafayette, IN 47907, USA., Yue F; Department of Animal Sciences, Purdue University, West Lafayette, IN 47907, USA., Kuang S; Department of Animal Sciences, Purdue University, West Lafayette, IN 47907, USA; Center for Cancer Research, Purdue University, West Lafayette, IN 47907, USA. Electronic address: skuang@purdue.edu.

Publikováno v: Cell reports [Cell Rep] 2023 Nov 28; Vol. 42 (11), pp. 113329. Date of Electronic Publication: 2023 Oct 25.

PRMT5 links lipid metabolism to contractile function of skeletal muscles.

Autor: Kim KH; Department of Animal Sciences, Purdue University, West Lafayette, IN, USA., Jia Z; Department of Animal Sciences, Purdue University, West Lafayette, IN, USA., Snyder M; Department of Animal Sciences, Purdue University, West Lafayette, IN, USA.; Department of Biological Sciences, Purdue University, West Lafayette, IN, USA., Chen J; Department of Animal Sciences, Purdue University, West Lafayette, IN, USA., Qiu J; Department of Animal Sciences, Purdue University, West Lafayette, IN, USA., Oprescu SN; Department of Animal Sciences, Purdue University, West Lafayette, IN, USA.; Department of Biological Sciences, Purdue University, West Lafayette, IN, USA., Chen X; Department of Animal Sciences, Purdue University, West Lafayette, IN, USA., Syed SA; Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA, USA., Yue F; Department of Animal Sciences, Purdue University, West Lafayette, IN, USA., Roseguini BT; Department of Health and Kinesiology, Purdue University, West Lafayette, IN, USA., Imbalzano AN; Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA, USA., Hu C; Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, IN, USA.; Center for Cancer Research, Purdue University, West Lafayette, IN, USA., Kuang S; Department of Animal Sciences, Purdue University, West Lafayette, IN, USA.; Center for Cancer Research, Purdue University, West Lafayette, IN, USA.

Publikováno v: EMBO reports [EMBO Rep] 2023 Aug 03; Vol. 24 (8), pp. e57306. Date of Electronic Publication: 2023 Jun 19.

Chemically-defined generation of human hemogenic endothelium and definitive hematopoietic progenitor cells.

Autor: Chang Y; Davidson School of Chemical Engineering, Purdue University, West Lafayette, IN, 47907, USA; Purdue University Center for Cancer Research, West Lafayette, IN, 47907, USA., Syahirah R; Department of Biological Sciences, Purdue University, West Lafayette, IN, 47907, USA., Oprescu SN; Purdue University Center for Cancer Research, West Lafayette, IN, 47907, USA; Department of Animal Sciences, Purdue University, West Lafayette, IN, 47907, USA., Wang X; Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN, 46202, USA., Jung J; Davidson School of Chemical Engineering, Purdue University, West Lafayette, IN, 47907, USA; Purdue University Center for Cancer Research, West Lafayette, IN, 47907, USA., Cooper SH; Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN, 46202, USA., Torregrosa-Allen S; Purdue University Center for Cancer Research, West Lafayette, IN, 47907, USA., Elzey BD; Purdue University Center for Cancer Research, West Lafayette, IN, 47907, USA; Department of Comparative Pathobiology, Purdue University, West Lafayette, IN, 47907, USA., Hsu AY; Department of Biological Sciences, Purdue University, West Lafayette, IN, 47907, USA; Department of Pathology, Harvard Medical School, Boston, MA, 02115, USA., Randolph LN; Departments of Biomedical Engineering, Biology, The Huck Institutes of the Life Sciences, The Pennsylvania State University, University Park, PA, 16802, USA., Sun Y; Davidson School of Chemical Engineering, Purdue University, West Lafayette, IN, 47907, USA., Kuang S; Purdue University Center for Cancer Research, West Lafayette, IN, 47907, USA; Department of Animal Sciences, Purdue University, West Lafayette, IN, 47907, USA., Broxmeyer HE; Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN, 46202, USA., Deng Q; Purdue University Center for Cancer Research, West Lafayette, IN, 47907, USA; Department of Biological Sciences, Purdue University, West Lafayette, IN, 47907, USA. Electronic address: qingdeng@purdue.edu., Lian X; Departments of Biomedical Engineering, Biology, The Huck Institutes of the Life Sciences, The Pennsylvania State University, University Park, PA, 16802, USA. Electronic address: Lian@psu.edu., Bao X; Davidson School of Chemical Engineering, Purdue University, West Lafayette, IN, 47907, USA; Purdue University Center for Cancer Research, West Lafayette, IN, 47907, USA. Electronic address: bao61@purdue.edu.

Publikováno v: Biomaterials [Biomaterials] 2022 Jun; Vol. 285, pp. 121569. Date of Electronic Publication: 2022 May 06.

Lipid droplet dynamics regulate adult muscle stem cell fate.

Autor: Yue F; Department of Animal Sciences, Purdue University, West Lafayette, IN 47907, USA. Electronic address: fyue@purdue.edu., Oprescu SN; Department of Animal Sciences, Purdue University, West Lafayette, IN 47907, USA; Department of Biological Sciences, Purdue University, West Lafayette, IN 47907, USA., Qiu J; Department of Animal Sciences, Purdue University, West Lafayette, IN 47907, USA., Gu L; Department of Animal Sciences, Purdue University, West Lafayette, IN 47907, USA., Zhang L; Department of Animal Sciences, Purdue University, West Lafayette, IN 47907, USA., Chen J; Department of Animal Sciences, Purdue University, West Lafayette, IN 47907, USA., Narayanan N; Department of Agricultural and Biological Engineering, Purdue University, West Lafayette, IN 47907, USA., Deng M; Department of Agricultural and Biological Engineering, Purdue University, West Lafayette, IN 47907, USA., Kuang S; Department of Animal Sciences, Purdue University, West Lafayette, IN 47907, USA; Center for Cancer Research, Purdue University, West Lafayette, IN 47907, USA. Electronic address: skuang@purdue.edu.

Publikováno v: Cell reports [Cell Rep] 2022 Jan 18; Vol. 38 (3), pp. 110267.