Fragmentation of tissue-resident macrophages during isolation confounds analysis of single-cell preparations from mouse hematopoietic tissues.

Autor: Millard SM; Mater Research Institute-The University of Queensland, Translational Research Institute, Woolloongabba, QLD 4102, Australia., Heng O; Mater Research Institute-The University of Queensland, Translational Research Institute, Woolloongabba, QLD 4102, Australia., Opperman KS; Myeloma Research Laboratory, Adelaide Medical School, Faculty of Health and Medical Sciences, University of Adelaide, North Terrace, Adelaide, SA 5005, Australia; South Australian Health and Medical Research Institute, PO Box 11060, Adelaide, SA 5001, Australia., Sehgal A; Mater Research Institute-The University of Queensland, Translational Research Institute, Woolloongabba, QLD 4102, Australia., Irvine KM; Mater Research Institute-The University of Queensland, Translational Research Institute, Woolloongabba, QLD 4102, Australia., Kaur S; Mater Research Institute-The University of Queensland, Translational Research Institute, Woolloongabba, QLD 4102, Australia; The University of Queensland, UQ Diamantina Institute, Brisbane, QLD 4102, Australia., Sandrock CJ; Mater Research Institute-The University of Queensland, Translational Research Institute, Woolloongabba, QLD 4102, Australia., Wu AC; Mater Research Institute-The University of Queensland, Translational Research Institute, Woolloongabba, QLD 4102, Australia; TRI Flow Cytometry Suite, Translational Research Institute, Woolloongabba, QLD 4102, Australia., Magor GW; Mater Research Institute-The University of Queensland, Translational Research Institute, Woolloongabba, QLD 4102, Australia; Australian Centre for Blood Diseases, Monash University, Melbourne, VIC 3004, Australia., Batoon L; Mater Research Institute-The University of Queensland, Translational Research Institute, Woolloongabba, QLD 4102, Australia., Perkins AC; Mater Research Institute-The University of Queensland, Translational Research Institute, Woolloongabba, QLD 4102, Australia; Australian Centre for Blood Diseases, Monash University, Melbourne, VIC 3004, Australia., Noll JE; Myeloma Research Laboratory, Adelaide Medical School, Faculty of Health and Medical Sciences, University of Adelaide, North Terrace, Adelaide, SA 5005, Australia; South Australian Health and Medical Research Institute, PO Box 11060, Adelaide, SA 5001, Australia., Zannettino ACW; Myeloma Research Laboratory, Adelaide Medical School, Faculty of Health and Medical Sciences, University of Adelaide, North Terrace, Adelaide, SA 5005, Australia; South Australian Health and Medical Research Institute, PO Box 11060, Adelaide, SA 5001, Australia; Central Adelaide Local Health Network, Adelaide, SA 5001, Australia., Sester DP; TRI Flow Cytometry Suite, Translational Research Institute, Woolloongabba, QLD 4102, Australia., Levesque JP; Mater Research Institute-The University of Queensland, Translational Research Institute, Woolloongabba, QLD 4102, Australia., Hume DA; Mater Research Institute-The University of Queensland, Translational Research Institute, Woolloongabba, QLD 4102, Australia., Raggatt LJ; Mater Research Institute-The University of Queensland, Translational Research Institute, Woolloongabba, QLD 4102, Australia., Summers KM; Mater Research Institute-The University of Queensland, Translational Research Institute, Woolloongabba, QLD 4102, Australia., Pettit AR; Mater Research Institute-The University of Queensland, Translational Research Institute, Woolloongabba, QLD 4102, Australia. Electronic address: allison.pettit@mater.uq.edu.au.

Publikováno v: Cell reports [Cell Rep] 2021 Nov 23; Vol. 37 (8), pp. 110058.

Targeted Disruption of Bone Marrow Stromal Cell-Derived Gremlin1 Limits Multiple Myeloma Disease Progression In Vivo.

Autor: Clark KC; Myeloma Research Laboratory, Adelaide Medical School, Faculty of Health and Medical Sciences, University of Adelaide, Adelaide, SA 5000, Australia.; Precision Medicine Theme, South Australian Health and Medical Research Institute, Adelaide, SA 5000, Australia., Hewett DR; Myeloma Research Laboratory, Adelaide Medical School, Faculty of Health and Medical Sciences, University of Adelaide, Adelaide, SA 5000, Australia.; Precision Medicine Theme, South Australian Health and Medical Research Institute, Adelaide, SA 5000, Australia., Panagopoulos V; Myeloma Research Laboratory, Adelaide Medical School, Faculty of Health and Medical Sciences, University of Adelaide, Adelaide, SA 5000, Australia.; Precision Medicine Theme, South Australian Health and Medical Research Institute, Adelaide, SA 5000, Australia., Plakhova N; Myeloma Research Laboratory, Adelaide Medical School, Faculty of Health and Medical Sciences, University of Adelaide, Adelaide, SA 5000, Australia.; Precision Medicine Theme, South Australian Health and Medical Research Institute, Adelaide, SA 5000, Australia., Opperman KS; Myeloma Research Laboratory, Adelaide Medical School, Faculty of Health and Medical Sciences, University of Adelaide, Adelaide, SA 5000, Australia.; Precision Medicine Theme, South Australian Health and Medical Research Institute, Adelaide, SA 5000, Australia., Bradey AL; Myeloma Research Laboratory, Adelaide Medical School, Faculty of Health and Medical Sciences, University of Adelaide, Adelaide, SA 5000, Australia.; Precision Medicine Theme, South Australian Health and Medical Research Institute, Adelaide, SA 5000, Australia., Mrozik KM; Myeloma Research Laboratory, Adelaide Medical School, Faculty of Health and Medical Sciences, University of Adelaide, Adelaide, SA 5000, Australia.; Precision Medicine Theme, South Australian Health and Medical Research Institute, Adelaide, SA 5000, Australia., Vandyke K; Myeloma Research Laboratory, Adelaide Medical School, Faculty of Health and Medical Sciences, University of Adelaide, Adelaide, SA 5000, Australia.; Precision Medicine Theme, South Australian Health and Medical Research Institute, Adelaide, SA 5000, Australia., Mukherjee S; Department of Medicine, Columbia University Medical Center, New York City, NY 10032, USA., Davies GCG; UCB (Union Chimique Belge) Pharma, Slough SL1 3WE, UK., Worthley DL; Precision Medicine Theme, South Australian Health and Medical Research Institute, Adelaide, SA 5000, Australia., Zannettino ACW; Myeloma Research Laboratory, Adelaide Medical School, Faculty of Health and Medical Sciences, University of Adelaide, Adelaide, SA 5000, Australia.; Precision Medicine Theme, South Australian Health and Medical Research Institute, Adelaide, SA 5000, Australia.; Central Adelaide Local Health Network, Adelaide, SA 5000, Australia.

Publikováno v: Cancers [Cancers (Basel)] 2020 Aug 03; Vol. 12 (8). Date of Electronic Publication: 2020 Aug 03.

GLIPR1 expression is reduced in multiple myeloma but is not a tumour suppressor in mice.

Autor: Friend N; Adelaide Medical School, Faculty of Health and Medical Sciences, University of Adelaide, Adelaide, Australia.; Cancer Program, Precision Medicine Theme, South Australian Health and Medical Research Institute, Adelaide, Australia., Noll JE; Adelaide Medical School, Faculty of Health and Medical Sciences, University of Adelaide, Adelaide, Australia.; Cancer Program, Precision Medicine Theme, South Australian Health and Medical Research Institute, Adelaide, Australia., Opperman KS; Adelaide Medical School, Faculty of Health and Medical Sciences, University of Adelaide, Adelaide, Australia.; Cancer Program, Precision Medicine Theme, South Australian Health and Medical Research Institute, Adelaide, Australia., Clark KC; Adelaide Medical School, Faculty of Health and Medical Sciences, University of Adelaide, Adelaide, Australia.; Cancer Program, Precision Medicine Theme, South Australian Health and Medical Research Institute, Adelaide, Australia., Mrozik KM; Adelaide Medical School, Faculty of Health and Medical Sciences, University of Adelaide, Adelaide, Australia.; Cancer Program, Precision Medicine Theme, South Australian Health and Medical Research Institute, Adelaide, Australia., Vandyke K; Adelaide Medical School, Faculty of Health and Medical Sciences, University of Adelaide, Adelaide, Australia.; Cancer Program, Precision Medicine Theme, South Australian Health and Medical Research Institute, Adelaide, Australia., Hewett DR; Adelaide Medical School, Faculty of Health and Medical Sciences, University of Adelaide, Adelaide, Australia.; Cancer Program, Precision Medicine Theme, South Australian Health and Medical Research Institute, Adelaide, Australia., Zannettino ACW; Adelaide Medical School, Faculty of Health and Medical Sciences, University of Adelaide, Adelaide, Australia.; Cancer Program, Precision Medicine Theme, South Australian Health and Medical Research Institute, Adelaide, Australia.

Publikováno v: PloS one [PLoS One] 2020 Jan 29; Vol. 15 (1), pp. e0228408. Date of Electronic Publication: 2020 Jan 29 (Print Publication: 2020).

A niche-dependent myeloid transcriptome signature defines dormant myeloma cells.

Autor: Khoo WH; Division of Bone Biology, Garvan Institute of Medical Research, Sydney, NSW, Australia.; School of Biotechnology and Biomolecular Sciences, University of New South Wales (UNSW) Sydney, Sydney, NSW, Australia., Ledergor G; Department of Immunology, Weizmann Institute of Science, Rehovot, Israel.; Department of Internal Medicine 'T', Tel Aviv Sourasky Medical Center, Tel Aviv, Israel., Weiner A; Department of Immunology, Weizmann Institute of Science, Rehovot, Israel., Roden DL; Cancer Division, Garvan Institute of Medical Research, Sydney, NSW, Australia., Terry RL; Division of Bone Biology, Garvan Institute of Medical Research, Sydney, NSW, Australia., McDonald MM; Division of Bone Biology, Garvan Institute of Medical Research, Sydney, NSW, Australia.; St Vincent's Clinical School, Faculty of Medicine, UNSW Sydney, Sydney, NSW, Australia., Chai RC; Division of Bone Biology, Garvan Institute of Medical Research, Sydney, NSW, Australia., De Veirman K; Department of Hematology and Immunology, Vrije Universiteit Brussel, Brussels, Belgium., Owen KL; Department of Biochemistry and Genetics, La Trobe University, Melbourne, VIC, Australia., Opperman KS; Faculty of Health and Medical Sciences, The University of Adelaide, Adelaide, SA, Australia.; Cancer Theme, South Australian Health and Medical Research Institute, Adelaide, SA, Australia., Vandyke K; Faculty of Health and Medical Sciences, The University of Adelaide, Adelaide, SA, Australia.; Cancer Theme, South Australian Health and Medical Research Institute, Adelaide, SA, Australia., Clark JR; Faculty of Health and Medical Sciences, The University of Adelaide, Adelaide, SA, Australia.; Cancer Theme, South Australian Health and Medical Research Institute, Adelaide, SA, Australia., Seckinger A; Labor für Myelomforschung, Medizinische Klinik V, Universitätsklinikum Heidelberg, Ruprecht-Karls-Universität Heidelberg, Heidelberg, Germany., Kovacic N; Department of Anatomy and Clinical Anatomy, University of Zagreb School of Medicine, Zagreb, Croatia., Nguyen A; St Vincent's Clinical School, Faculty of Medicine, UNSW Sydney, Sydney, NSW, Australia.; Immunology Division, Garvan Institute of Medical Research, Sydney, NSW, Australia., Mohanty ST; Division of Bone Biology, Garvan Institute of Medical Research, Sydney, NSW, Australia., Pettitt JA; Division of Bone Biology, Garvan Institute of Medical Research, Sydney, NSW, Australia., Xiao Y; Division of Bone Biology, Garvan Institute of Medical Research, Sydney, NSW, Australia., Corr AP; Division of Bone Biology, Garvan Institute of Medical Research, Sydney, NSW, Australia.; St Vincent's Clinical School, Faculty of Medicine, UNSW Sydney, Sydney, NSW, Australia., Seeliger C; Division of Bone Biology, Garvan Institute of Medical Research, Sydney, NSW, Australia., Novotny M; J. Craig Venter Institute, La Jolla, CA., Lasken RS; J. Craig Venter Institute, La Jolla, CA., Nguyen TV; Division of Bone Biology, Garvan Institute of Medical Research, Sydney, NSW, Australia.; St Vincent's Clinical School, Faculty of Medicine, UNSW Sydney, Sydney, NSW, Australia.; School of Biomedical Engineering, University of Technology, Sydney, NSW, Australia., Oyajobi BO; Department of Cell Systems and Anatomy, Long School of Medicine, and.; Mays Cancer Center, University of Texas Health Science Center, San Antonio, TX; and., Aftab D; Exelixis Inc, Alameda, CA., Swarbrick A; Cancer Division, Garvan Institute of Medical Research, Sydney, NSW, Australia.; St Vincent's Clinical School, Faculty of Medicine, UNSW Sydney, Sydney, NSW, Australia., Parker B; Department of Biochemistry and Genetics, La Trobe University, Melbourne, VIC, Australia., Hewett DR; Faculty of Health and Medical Sciences, The University of Adelaide, Adelaide, SA, Australia.; Cancer Theme, South Australian Health and Medical Research Institute, Adelaide, SA, Australia., Hose D; Labor für Myelomforschung, Medizinische Klinik V, Universitätsklinikum Heidelberg, Ruprecht-Karls-Universität Heidelberg, Heidelberg, Germany., Vanderkerken K; Department of Hematology and Immunology, Vrije Universiteit Brussel, Brussels, Belgium., Zannettino ACW; Faculty of Health and Medical Sciences, The University of Adelaide, Adelaide, SA, Australia.; Cancer Theme, South Australian Health and Medical Research Institute, Adelaide, SA, Australia., Amit I; Department of Immunology, Weizmann Institute of Science, Rehovot, Israel., Phan TG; St Vincent's Clinical School, Faculty of Medicine, UNSW Sydney, Sydney, NSW, Australia.; Immunology Division, Garvan Institute of Medical Research, Sydney, NSW, Australia., Croucher PI; Division of Bone Biology, Garvan Institute of Medical Research, Sydney, NSW, Australia.; School of Biotechnology and Biomolecular Sciences, University of New South Wales (UNSW) Sydney, Sydney, NSW, Australia.; St Vincent's Clinical School, Faculty of Medicine, UNSW Sydney, Sydney, NSW, Australia.

Publikováno v: Blood [Blood] 2019 Jul 04; Vol. 134 (1), pp. 30-43. Date of Electronic Publication: 2019 Apr 25.