ADAP is an upstream regulator that precedes SLP-76 at sites of TCR engagement and stabilizes signaling microclusters.

Autor: Lewis JB; Program in Immunology, Sackler School of Graduate Biomedical Sciences, Tufts University School of Medicine, Boston, MA 02111, USA., Scangarello FA; Program in Immunology, Sackler School of Graduate Biomedical Sciences, Tufts University School of Medicine, Boston, MA 02111, USA.; Medical Scientist Training Program, Sackler School of Graduate Biomedical Sciences, Tufts University School of Medicine, Boston, MA 02111, USA., Murphy JM; Department of Immunology, Tufts University School of Medicine, Boston, MA 02111, USA., Eidell KP; Program in Immunology, Sackler School of Graduate Biomedical Sciences, Tufts University School of Medicine, Boston, MA 02111, USA., Sodipo MO; Department of Immunology, Tufts University School of Medicine, Boston, MA 02111, USA., Ophir MJ; Program in Immunology, Sackler School of Graduate Biomedical Sciences, Tufts University School of Medicine, Boston, MA 02111, USA., Sargeant R; Pacific Immunology Corporation, Ramona, CA 92065, USA., Seminario MC; Department of Immunology, Tufts University School of Medicine, Boston, MA 02111, USA., Bunnell SC; Program in Immunology, Sackler School of Graduate Biomedical Sciences, Tufts University School of Medicine, Boston, MA 02111, USA stephen.bunnell@tufts.edu.; Department of Immunology, Tufts University School of Medicine, Boston, MA 02111, USA.

Publikováno v: Journal of cell science [J Cell Sci] 2018 Nov 08; Vol. 131 (21). Date of Electronic Publication: 2018 Nov 08.

The N terminus of SKAP55 enables T cell adhesion to TCR and integrin ligands via distinct mechanisms.

Autor: Ophir MJ; Program in Immunology, Sackler School of Graduate Biomedical Sciences, and 2 Department of Integrative Physiology and Pathobiology, Tufts University School of Medicine, Boston, MA 02111., Liu BC, Bunnell SC

Publikováno v: The Journal of cell biology [J Cell Biol] 2013 Dec 23; Vol. 203 (6), pp. 1021-41.

Rap1 prevents colitogenic Th17 cell expansion and facilitates Treg cell differentiation and distal TCR signaling.

Autor: Ishihara, Sayaka¹ (AUTHOR), Sato, Tsuyoshi¹ (AUTHOR), Fujikado, Noriyuki² (AUTHOR), Miyazaki, Haruka¹ (AUTHOR), Yoshimoto, Takayuki³ (AUTHOR), Yamamoto, Hiromitsu⁴ (AUTHOR), Fukuda, Shinji^4,5,6 (AUTHOR), Katagiri, Koko¹ (AUTHOR) katagirk@kitasato-u.ac.jp

Publikováno v: Communications Biology. 3/4/2022, Vol. 5 Issue 1, p1-17. 17p.

Mapping the SLP76 interactome in T cells lacking each of the GRB2-family adaptors reveals molecular plasticity of the TCR signaling pathway.

Autor: Ruminski, Kilian, Celis-Gutierrez, Javier, Jarmuzynski, Nicolas, Maturin, Emilie, Audebert, Stephane, Malissen, Marie, Camoin, Luc, Voisinne, Guillaume, Malissen, Bernard, Roncagalli, Romain

Publikováno v: Frontiers in Immunology; 3/15/2023, Vol. 14, p1-14, 14p

Immunomodulatory Yersinia outer proteins (Yops)-useful tools for bacteria and humans alike.

Autor: Grabowski, Benjamin¹ (AUTHOR), Schmidt, M. Alexander¹ (AUTHOR) infekt@uni-muenster.de, Rüter, Christian¹ (AUTHOR)

Publikováno v: Virulence. Oct2017, Vol. 8 Issue 7, p1124-1147. 24p.