Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Opher S Kornfeld"'
Autor:
Elisabet Bjanes, Reyna Garcia Sillas, Rina Matsuda, Benjamin Demarco, Timothée Fettrelet, Alexandra A DeLaney, Opher S Kornfeld, Bettina L Lee, Eric M Rodríguez López, Daniel Grubaugh, Meghan A Wynosky-Dolfi, Naomi H Philip, Elise Krespan, Dorothy Tovar, Leonel Joannas, Daniel P Beiting, Jorge Henao-Mejia, Brian C Schaefer, Kaiwen W Chen, Petr Broz, Igor E Brodsky
Publikováno v:
PLoS Pathogens, Vol 17, Iss 10, p e1009967 (2021)
Cell death plays a critical role in inflammatory responses. During pyroptosis, inflammatory caspases cleave Gasdermin D (GSDMD) to release an N-terminal fragment that generates plasma membrane pores that mediate cell lysis and IL-1 cytokine release.
Externí odkaz:
https://doaj.org/article/8d9976e5a9e54adc98393333ee0b5aa5
Autor:
Juan Zhang, Donghong Yan, Christopher C. Goodnow, Wendy Sandoval, Jian Payandeh, Bettina L. Lee, Qingling Li, Vicky Cho, Irma B. Stowe, Zora Modrusan, Lisa A. Miosge, Min Xu, Rohit Reja, Gözde Ulas, Merone Roose-Girma, Jing Kang, T. Daniel Andrews, Opher S. Kornfeld, Vishva M. Dixit, Karen O'Rourke, Joshua D. Webster, Wyne P. Lee, Brent S. McKenzie, Meredith Sagolla, Nobuhiko Kayagaki, Lucy X. Morris, Edward M. Bertram
Publikováno v:
Nature. 591:131-136
Plasma membrane rupture (PMR) is the final cataclysmic event in lytic cell death. PMR releases intracellular molecules known as damage-associated molecular patterns (DAMPs) that propagate the inflammatory response1-3. The underlying mechanism of PMR,
Autor:
Alexandra DeLaney, Opher S. Kornfeld, Bettina L. Lee, Daniel P. Beiting, Eric M. Rodriguez Lopez, Petr Broz, Timothée Fettrelet, Jorge Henao-Mejia, Daniel Grubaugh, Elisabet Bjanes, Benjamin Demarco, Reyna Garcia Sillas, Elise Krespan, Kaiwen W. Chen, Igor E. Brodsky, Meghan A. Wynosky-Dolfi, Dorothy Tovar, Rina Matsuda, Naomi H. Philip, Leonel Joannas, Brian C. Schaefer
Publikováno v:
PLoS Pathogens, Vol 17, Iss 10, p e1009967 (2021)
PLoS Pathogens
Plos Pathogens
PLoS pathogens, vol. 17, no. 10, pp. e1009967
PLoS Pathogens
Plos Pathogens
PLoS pathogens, vol. 17, no. 10, pp. e1009967
Cell death plays a critical role in inflammatory responses. During pyroptosis, inflammatory caspases cleave Gasdermin D (GSDMD) to release an N-terminal fragment that generates plasma membrane pores that mediate cell lysis and IL-1 cytokine release.
Autor:
Meghan A. Wynosky-Dolfi, Elise Krespan, Reyna Garcia Sillas, Petr Broz, Opher S. Kornfeld, Kaiwen W. Chen, Jorge Henao-Mejia, Daniel Grubaugh, Elisabet Bjanes, Timothée Fettrelet, Alexandra DeLaney, Benjamin Demarco, Rina Matsuda, Dorothy Tovar, Eric M. Rodriguez Lopez, Naomi H. Philip, Leonel Joannas, Brian C. Schaefer, Daniel P. Beiting, Igor E. Brodsky, Bettina L. Lee
Cell death plays a critical role in inflammatory responses. During pyroptosis, inflammatory caspases cleave Gasdermin D (GSDMD) to release an N-terminal fragment that generates plasma membrane pores that mediate cell lysis and IL-1 cytokine release.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7d4e82de528db10234c8640e54e62584
https://doi.org/10.1101/2021.03.19.436207
https://doi.org/10.1101/2021.03.19.436207
Autor:
Nobuhiko, Kayagaki, Opher S, Kornfeld, Bettina L, Lee, Irma B, Stowe, Karen, O'Rourke, Qingling, Li, Wendy, Sandoval, Donghong, Yan, Jing, Kang, Min, Xu, Juan, Zhang, Wyne P, Lee, Brent S, McKenzie, Gözde, Ulas, Jian, Payandeh, Merone, Roose-Girma, Zora, Modrusan, Rohit, Reja, Meredith, Sagolla, Joshua D, Webster, Vicky, Cho, T Daniel, Andrews, Lucy X, Morris, Lisa A, Miosge, Christopher C, Goodnow, Edward M, Bertram, Vishva M, Dixit
Publikováno v:
Nature. 591(7848)
Plasma membrane rupture (PMR) is the final cataclysmic event in lytic cell death. PMR releases intracellular molecules known as damage-associated molecular patterns (DAMPs) that propagate the inflammatory response
Autor:
Bereketeab Haileselassie, Mehrdad Shamloo, Opher S. Kornfeld, Daria Mochly-Rosen, Paolo Bernardi, Nir Qvit
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-9 (2018)
Mitochondria form a dynamic network governed by a balance between opposing fission and fusion processes. Because excessive mitochondrial fission correlates with numerous pathologies, including neurodegeneration, the mechanism governing fission has be
Publikováno v:
Angewandte Chemie. 128:15901-15908
Most protein kinases phosphorylate multiple substrates, each of which induces different and sometimes opposing functions. Determining the role of phosphorylation of each substrate following a specific stimulus is challenging but is essential to eluci
Autor:
Nobuhiko, Kayagaki, Bettina L, Lee, Irma B, Stowe, Opher S, Kornfeld, Karen, O'Rourke, Kathleen M, Mirrashidi, Benjamin, Haley, Colin, Watanabe, Merone, Roose-Girma, Zora, Modrusan, Sarah, Kummerfeld, Rohit, Reja, Yafei, Zhang, Vicky, Cho, T Daniel, Andrews, Lucy X, Morris, Christopher C, Goodnow, Edward M, Bertram, Vishva M, Dixit
Publikováno v:
Science signaling. 12(582)
Gasdermin-D (GSDMD) is cleaved by caspase-1, caspase-4, and caspase-11 in response to canonical and noncanonical inflammasome activation. Upon cleavage, GSDMD oligomerizes and forms plasma membrane pores, resulting in interleukin-1β (IL-1β) secreti
Autor:
Christopher C. Goodnow, Zora Modrusan, Irma B. Stowe, Rohit Reja, Bettina L. Lee, Sarah K. Kummerfeld, T. Daniel Andrews, Vishva M. Dixit, Benjamin Haley, Karen O'Rourke, Lucy X. Morris, Edward M. Bertram, Kathleen M. Mirrashidi, Yafei Zhang, Merone Roose-Girma, Nobuhiko Kayagaki, Vicky Cho, Colin K. Watanabe, Opher S. Kornfeld
Publikováno v:
Science Signaling. 12
Gasdermin-D (GSDMD) is cleaved by caspase-1, caspase-4, and caspase-11 in response to canonical and noncanonical inflammasome activation. Upon cleavage, GSDMD oligomerizes and forms plasma membrane pores, resulting in interleukin-1β (IL-1β) secreti
Publikováno v:
The FASEB Journal. 33