Zobrazeno 1 - 10
of 55
pro vyhledávání: '"Ophélia Maertens"'
Autor:
AeRang Kim, Yao Lu, Scott H. Okuno, Denise Reinke, Ophélia Maertens, John Perentesis, Mitali Basu, Pamela L. Wolters, Thomas De Raedt, Sant Chawla, Rashmi Chugh, Brian A. Van Tine, Geraldine O’Sullivan, Alice Chen, Karen Cichowski, Brigitte C. Widemann
Publikováno v:
Sarcoma, Vol 2020 (2020)
Purpose. Malignant peripheral nerve sheath tumors (MPNSTs) are aggressive soft tissue sarcomas. Combining Hsp90 inhibitors to enhance endoplasmic reticulum stress with mTOR inhibition results in dramatic MPNST shrinkage in a genetically engineered MP
Externí odkaz:
https://doaj.org/article/1f1a358664ee478b94751c3fec57799c
Autor:
Pasi A. Jänne, Kwok-Kin Wong, Nathanael S. Gray, Neal Rosen, Matthew J. Lazzara, Levi A. Garraway, Anthony Letai, Eva M. Goetz, Ophélia Maertens, Marzia Capelletti, Claire Repellin, Andrew Rogers, Madhavi Tadi, Elena V. Ivanova, Lynette Sholl, Takeshi Shimamura, Mohit Butaney, Joan Montero, Christine A. Pratilas, Calixte S. Monast, Masahiko Yanagita, Chunxiao Xu, Dalia Ercan
PDF file - 1.3MB, Supplementary data on MAPK1 copy number and expression, combination treatment with WZ4002 and PI3K inhibitors, impact of MEK1 K57N on WZ4002 sensitivity, Mapk1 copy number analyses and NF1 and dusp expression in drug sensitive and r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8830faf5a940d56a975c44bb2350b97b
https://doi.org/10.1158/2159-8290.22528668
https://doi.org/10.1158/2159-8290.22528668
Autor:
Karen Cichowski, Richard Marais, Jennifer A. Wargo, Keith Flaherty, Scott Granter, Martin McMahon, Roderick T. Bronson, Ludwine Messiaen, Zachary A. Cooper, Dennie T. Frederick, Pablo Hollstein, Bryan Johnson, Ophélia Maertens
PDF file - 78K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::480570f94b4e301f1168448e0a451863
https://doi.org/10.1158/2159-8290.22529835
https://doi.org/10.1158/2159-8290.22529835
Autor:
Karen Cichowski, Rachel Ingraham, Thomas DeRaedt, Ophélia Maertens, Jody A. Fromm, Clare F. Malone
PDF file - 107KB, Two class comparison between combination treated samples and controls for the other GLUT proteins and hexokinses. The log2 of fold (combination/control) expression for each gene in the GLUT and hexokinase family are shown, such that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a137c478af970946590ce8f1b47010af
https://doi.org/10.1158/2159-8290.22532282
https://doi.org/10.1158/2159-8290.22532282
Autor:
Pasi A. Jänne, Kwok-Kin Wong, Nathanael S. Gray, Neal Rosen, Matthew J. Lazzara, Levi A. Garraway, Anthony Letai, Eva M. Goetz, Ophélia Maertens, Marzia Capelletti, Claire Repellin, Andrew Rogers, Madhavi Tadi, Elena V. Ivanova, Lynette Sholl, Takeshi Shimamura, Mohit Butaney, Joan Montero, Christine A. Pratilas, Calixte S. Monast, Masahiko Yanagita, Chunxiao Xu, Dalia Ercan
PDF file - 83K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7388e39af86730e51b79a6bed45d0875
https://doi.org/10.1158/2159-8290.22528671
https://doi.org/10.1158/2159-8290.22528671
Autor:
Karen Cichowski, Richard Marais, Jennifer A. Wargo, Keith Flaherty, Scott Granter, Martin McMahon, Roderick T. Bronson, Ludwine Messiaen, Zachary A. Cooper, Dennie T. Frederick, Pablo Hollstein, Bryan Johnson, Ophélia Maertens
PDF file - 96K, Schwann cells (RT4) expressing an inducible RAF construct (∆RAF:ER) were treated with the indicated concentrations of hydroxy-tamoxifen (4-OHT) in the absence and presence of a short hairpin RNA (shRNA) specific for NF1. RAS-GTP lev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b12561c3890b197a6ba849eb361b21b9
https://doi.org/10.1158/2159-8290.22529841.v1
https://doi.org/10.1158/2159-8290.22529841.v1
Autor:
Karen Cichowski, Richard Marais, Jennifer A. Wargo, Keith Flaherty, Scott Granter, Martin McMahon, Roderick T. Bronson, Ludwine Messiaen, Zachary A. Cooper, Dennie T. Frederick, Pablo Hollstein, Bryan Johnson, Ophélia Maertens
PDF file - 175K, Dose response curves for PLX4720 in BRAFV600E mutant melanoma cell lines (WM3526 (A) and A375 (B)) in the absence or presence of a short hairpin RNA (shRNA) specific for NF1. Cells were treated with PLX4720 at the indicated concentra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b303d9ab150af501d17a3b4c04dfdf6
https://doi.org/10.1158/2159-8290.22529838.v1
https://doi.org/10.1158/2159-8290.22529838.v1
Autor:
Karen Cichowski, Richard Marais, Jennifer A. Wargo, Keith Flaherty, Scott Granter, Martin McMahon, Roderick T. Bronson, Ludwine Messiaen, Zachary A. Cooper, Dennie T. Frederick, Pablo Hollstein, Bryan Johnson, Ophélia Maertens
PDF file - 84K, Supplementary Table 1. NF1 and BRAF mutations identified in human melanoma cell lines. Data were generated in this study when specified and collected from publicly available databases. (CCLE: Cancer Cell Line Encyclopedia, COSMIC: Cat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bed57fb5f3d27a957feea6781923264
https://doi.org/10.1158/2159-8290.22529832.v1
https://doi.org/10.1158/2159-8290.22529832.v1
Supplementary Table 1 from Reactivation of ERK Signaling Causes Resistance to EGFR Kinase Inhibitors
Autor:
Pasi A. Jänne, Kwok-Kin Wong, Nathanael S. Gray, Neal Rosen, Matthew J. Lazzara, Levi A. Garraway, Anthony Letai, Eva M. Goetz, Ophélia Maertens, Marzia Capelletti, Claire Repellin, Andrew Rogers, Madhavi Tadi, Elena V. Ivanova, Lynette Sholl, Takeshi Shimamura, Mohit Butaney, Joan Montero, Christine A. Pratilas, Calixte S. Monast, Masahiko Yanagita, Chunxiao Xu, Dalia Ercan
PDF file - 74K, Table describing clinical and molecular characteristics of NSCLC patients
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9076c8b2a0853e2e5041bc6884cf9e3b
https://doi.org/10.1158/2159-8290.22528665
https://doi.org/10.1158/2159-8290.22528665
Autor:
Karen Cichowski, Rachel Ingraham, Thomas DeRaedt, Ophélia Maertens, Jody A. Fromm, Clare F. Malone
PDF file - 47KB, Supplementary Figure 1 shows that AKT inhibition does not slow proliferation in a human MPNST cell line.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d5cd4d26a5895bc0c82b7e59e7813c8
https://doi.org/10.1158/2159-8290.22532291.v1
https://doi.org/10.1158/2159-8290.22532291.v1