Výsledky vyhledávání - "Ophélie Nicolle"

Akademický článek

Dynamic Formation of Microvillus Inclusions During Enterocyte Differentiation in Munc18-2–Deficient Intestinal OrganoidsSummary

Autor: Mohammed H. Mosa, Ophélie Nicolle, Sophia Maschalidi, Fernando E. Sepulveda, Aurelien Bidaud-Meynard, Constantin Menche, Birgitta E. Michels, Grégoire Michaux, Geneviève de Saint Basile, Henner F. Farin

Publikováno v: Cellular and Molecular Gastroenterology and Hepatology, Vol 6, Iss 4, Pp 477-493.e1 (2018)

Background & Aims: Microvillus inclusion disease (MVID) is a congenital intestinal malabsorption disorder caused by defective apical vesicular transport. Existing cellular models do not fully recapitulate this heterogeneous pathology. The aim of this

Externí odkaz: https://doaj.org/article/ef293e491f7240379703b18ddd4ab05a

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The clathrin adaptor AP-1B independently controls proliferation and differentiation in the mammalian intestine

Autor: Maela Duclos, Anne Bourdais, Ophélie Nicolle, Grégoire Michaux, Aurélien Bidaud-Meynard

Maintenance of the polarity of the epithelial cells facing the lumen of the small intestine is crucial to ensure the vectorial absorption of nutrients as well as the integrity of the apical brush border and the intestinal barrier. Polarized vesicular

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::aaa3026926bc7c712c46068057817f49
https://doi.org/10.1101/2023.05.12.540539

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PAR-4/LKB1 regulates intestinal cell number by restricting endoderm specification to the E lineage

Autor: Flora Demouchy, Ophélie Nicolle, Grégoire Michaux, Anne Pacquelet

The master kinase PAR-4/LKB1 appears as a major regulator of intestinal physiology. It is in particular mutated in the Peutz-Jeghers syndrome, an inherited disorder in which patients develop benign intestine polyps. Moreover, ectopic activation of PA

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5afffda220e882f9922c076f0a431f88
https://hal.science/hal-03859203

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V0-ATPase downregulation induces MVID-like brush border defects independently of apical trafficking in the mammalian intestine

Autor: Aurélien Bidaud-Meynard, Ophélie Nicolle, Anne Bourdais, Maela Duclos, Jad Saleh, Frank Ruemmele, Henner F Farin, Delphine Delacour, Despina Moshous, Grégoire Michaux

Publikováno v: BioRxiv
BioRxiv, 2022, ⟨10.1101/2022.11.04.515188⟩

SummaryIntestinal microvillus atrophy is a major cause of enteropathies such as idiopathic or congenital diarrhea that are often associated with severe morbidity. It can be caused by genetic disorders, inflammatory diseases, toxins or pathogens. In p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4952918ea8e1b8d5ba0b90922c9baeac
https://hal.science/hal-03854108/document

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High-resolution dynamic mapping of the C. elegans intestinal brush border

Autor: Grégoire Michaux, Anne Pacquelet, Camille N. Plancke, François Robin, Aurélien Bidaud-Meynard, Flora Demouchy, Ophélie Nicolle, Shashi Kumar Suman

Publikováno v: Development (Cambridge, England)
Development (Cambridge, England), Company of Biologists, 2021, ⟨10.1242/dev.200029⟩
Development
Development (Cambridge, England), 2021, 148 (23), ⟨10.1242/dev.200029⟩

The intestinal brush border is made of an array of microvilli that increases the membrane surface area for nutrient processing, absorption, and host defence. Studies on mammalian cultured epithelial cells uncovered some of the molecular players and p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9881823ef7f120a7ad864ba27ce1bd4
https://pubmed.ncbi.nlm.nih.gov/34704594

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C-terminal phosphorylation modulates ERM-1 localization and dynamics to control cortical actin organization and support lumen formation during

Autor: João J, Ramalho, Jorian J, Sepers, Ophélie, Nicolle, Ruben, Schmidt, Janine, Cravo, Grégoire, Michaux, Mike, Boxem

Publikováno v: Development (Cambridge, England). 147(14)

ERM proteins are conserved regulators of cortical membrane specialization that function as membrane-actin linkers and molecular hubs. The activity of ERM proteins requires a conformational switch from an inactive cytoplasmic form into an active membr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::5b96cb9981fc13123f2ee4d89430b713
https://pubmed.ncbi.nlm.nih.gov/32586975

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In vivo control of the ezrin/radixin/moesin protein ERM-1 in C. elegans

Autor: Ophélie Nicolle, Mike Boxem, João J. Ramalho, Grégoire Michaux

ERM proteins are conserved regulators of cortical membrane specialization, that function as membrane–actin linkers and molecular hubs. Activity of ERM proteins requires a conformational switch from an inactive cytoplasmic form into an active membra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1315eb4e91046974d32ac9d7442e97b7

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A V0-ATPase-dependent apical trafficking pathway maintains the polarity of the intestinal absorptive membrane

Autor: Grégoire Michaux, Yann Le Cunff, Markus Heck, Ophélie Nicolle, Aurélien Bidaud-Meynard

Publikováno v: Development (Cambridge, England)
Development (Cambridge, England), 2019, 146 (11), pp.174508. ⟨10.1242/dev.174508⟩
Development (Cambridge, England), Company of Biologists, 2019, 146 (11), pp.174508. ⟨10.1242/dev.174508⟩
Development

Intestine function relies on the strong polarity of intestinal epithelial cells and the array of microvilli forming a brush border at their luminal pole. Combining a genetic RNA interference (RNAi) screen with in vivo super-resolution imaging in the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4dc01b2866852ccac21766c7295300ad
https://univ-rennes.hal.science/hal-02153480/document

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