Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Ophélie Gourgas"'
Autor:
Ophélie Gourgas, Gabrielle Lemire, Alison J. Eaton, Sultanah Alshahrani, Angela L. Duker, Jingjing Li, Ricki S. Carroll, Stuart Mackenzie, Sarah M. Nikkel, Care4Rare Canada Consortium, Michael B. Bober, Kym M. Boycott, Monzur Murshed
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-20 (2023)
Abstract Matrix Gla protein (MGP) is a vitamin K-dependent post-translationally modified protein, highly expressed in vascular and cartilaginous tissues. It is a potent inhibitor of extracellular matrix mineralization. Biallelic loss-of-function vari
Externí odkaz:
https://doaj.org/article/da25b033c7fc4486b1e0a997e6fbb6d0
Autor:
Ophélie Gourgas, Gabrielle Lemire, Alison J. Eaton, Sultanah Alshahrani, Angela L. Duker, Jingjing Li, Ricki S. Carroll, Stuart Mackenzie, Sarah M. Nikkel, Care4Rare Canada Consortium, Michael B. Bober, Kym M. Boycott, Monzur Murshed
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-1 (2024)
Externí odkaz:
https://doaj.org/article/baf17e51d8864a008f9a109bd76b1197
Autor:
Bin Yu, PhD, Anouar Hafiane, PhD, George Thanassoulis, MD, Leah Ott, BS, Nial Filwood, MD, Marta Cerruti, PhD, Ophélie Gourgas, MS, Dominique Shum-Tim, MD, Hamood Al Kindi, MD, Benoit de Varennes, MD, Alawi Alsheikh-Ali, MD, PhD, Jacques Genest, MD, Adel Schwertani, DM, PhD
Publikováno v:
JACC: Basic to Translational Science, Vol 2, Iss 4, Pp 358-371 (2017)
Lipoprotein(a), or Lp(a), significantly increased alkaline phosphatase activity, release of phosphate, calcium deposition, hydroxyapatite, cell apoptosis, matrix vesicle formation, and phosphorylation of signal transduction proteins; increased expres
Externí odkaz:
https://doaj.org/article/b14075748f2349b1b7679c98085a3718
Autor:
Yousif Shalal, Ophélie Gourgas, Jean-Claude Tardif, Hossney Alaws, Isabella Albanese, Marta Cerutti, Hamood Al-Kindi, Bin Yu, K. Khan, Adel Schwertani
Publikováno v:
The Journal of Thoracic and Cardiovascular Surgery. 161:e1-e15
Aortic valve stenosis (AVS) is the most common cause of surgical valve replacement worldwide. The vasoactive peptide urotensin II (UII) is upregulated in atherosclerosis and several other cardiovascular diseases; however, its role in the pathogenesis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5043e6f94eddb14fc0cce77ba198308c
https://doi.org/10.1016/j.jtcvs.2019.09.029
https://doi.org/10.1016/j.jtcvs.2019.09.029
Publikováno v:
Crystal Growth & Design. 20:7170-7179
During medial calcification, calcium phosphate minerals deposit in the medial layer of arteries, causing their stiffening. Although elastin (ELN) has been shown to be the main site for mineral depo...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::42a16b44d6fd2387c416645a33a458e0
https://doi.org/10.1021/acs.cgd.0c00759
https://doi.org/10.1021/acs.cgd.0c00759
Publikováno v:
Acta Biomaterialia. 106:342-350
Aortic valve calcification leads to the deposition of calcium phosphate minerals in the extracellular matrix of the aortic valve leaflets. The mineral deposits can severely narrow the opening of the aortic valve, leading to aortic stenosis. There are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5016f74cf952314d30d86643e702622
https://doi.org/10.1016/j.actbio.2020.02.030
https://doi.org/10.1016/j.actbio.2020.02.030
Publikováno v:
Langmuir. 35:15364-15375
Deposition of calcium phosphate minerals on the elastin-rich medial layers of arteries can cause severe cardiovascular complications. There are no available treatments for medial calcification, and the mechanism of mineral formation on elastin layers
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::874e79d646b508a7898ab6e2d82dbef1
https://doi.org/10.1021/acs.langmuir.9b02542
https://doi.org/10.1021/acs.langmuir.9b02542
Autor:
Ophélie Gourgas, Abhinav Parashar, Simon Sharpe, Monzur Murshed, Jingjing Li, Lisa D. Muiznieks, Kirk Lau, Elaine C. Davis, Marta Cerruti
Publikováno v:
Journal of structural biology. 213(1)
Medial calcification has been associated with diabetes, chronic kidney disease, and genetic disorders like pseudoxanthoma elasticum. Recently, we showed that genetic reduction of arterial elastin content reduces the severity of medial calcification i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3c960e7accc4cb75a16ab509381fcc7
https://pubmed.ncbi.nlm.nih.gov/33059036
https://pubmed.ncbi.nlm.nih.gov/33059036
Autor:
Shaker Alsharif, V. Gaëlle Roullin, Ophélie Gourgas, Xavier Banquy, Soudeh F. Tehrani, Pierre-Luc Latreille
Publikováno v:
Colloids and Surfaces A: Physicochemical and Engineering Aspects. 529:739-749
In this study, we compare the release mechanisms from nanocomposite hydrogels. Liposomes made of different compositions of 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC) and 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine (DPPC), nanogels made of chi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30782485440714f9b92744ece361ede6
https://doi.org/10.1016/j.colsurfa.2017.05.089
https://doi.org/10.1016/j.colsurfa.2017.05.089
Autor:
Alawi A. Alsheikh-Ali, Bin Yu, Leah Ott, Ophélie Gourgas, Marta Cerruti, Benoit de Varennes, Anouar Hafiane, Hamood Al Kindi, Dominique Shum-Tim, Adel Schwertani, Jacques Genest, George Thanassoulis, Nial Filwood
Publikováno v:
JACC: Basic to Translational Science, Vol 2, Iss 4, Pp 358-371 (2017)
JACC: Basic to Translational Science
JACC: Basic to Translational Science
Visual Abstract
Highlights • Lp(a) significantly increased alkaline phosphatase activity, phosphate and calcium content, and matrix vesicle formation and induced apoptosis and calcification of normal human aortic valve interstitial cells. •
Highlights • Lp(a) significantly increased alkaline phosphatase activity, phosphate and calcium content, and matrix vesicle formation and induced apoptosis and calcification of normal human aortic valve interstitial cells. •
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0424038108b253766f655db4c0850b7
http://www.sciencedirect.com/science/article/pii/S2452302X17301341
http://www.sciencedirect.com/science/article/pii/S2452302X17301341