Downregulation of V-ATPase V0 Sector Induces Microvillus Atrophy Independently of Apical Trafficking in the Mammalian Intestine

Autor: Aurélien Bidaud-Meynard, Anne Bourdais, Ophélie Nicolle, Maela Duclos, Jad Saleh, Frank M. Ruemmele, Henner F. Farin, Delphine Delacour, Despina Moshous, Grégoire Michaux

Publikováno v: Cellular and Molecular Gastroenterology and Hepatology, Vol 17, Iss 6, Pp 1072-1075 (2024)

Externí odkaz: https://doaj.org/article/17e3bd79c7ab45dea4123ebff58c2eeb

Dynamic Formation of Microvillus Inclusions During Enterocyte Differentiation in Munc18-2–Deficient Intestinal OrganoidsSummary

Autor: Mohammed H. Mosa, Ophélie Nicolle, Sophia Maschalidi, Fernando E. Sepulveda, Aurelien Bidaud-Meynard, Constantin Menche, Birgitta E. Michels, Grégoire Michaux, Geneviève de Saint Basile, Henner F. Farin

Publikováno v: Cellular and Molecular Gastroenterology and Hepatology, Vol 6, Iss 4, Pp 477-493.e1 (2018)

Background & Aims: Microvillus inclusion disease (MVID) is a congenital intestinal malabsorption disorder caused by defective apical vesicular transport. Existing cellular models do not fully recapitulate this heterogeneous pathology. The aim of this

Externí odkaz: https://doaj.org/article/ef293e491f7240379703b18ddd4ab05a

V0-ATPase downregulation induces MVID-like brush border defects independently of apical trafficking in the mammalian intestine

Autor: Aurélien Bidaud-Meynard, Ophélie Nicolle, Anne Bourdais, Maela Duclos, Jad Saleh, Frank Ruemmele, Henner F Farin, Delphine Delacour, Despina Moshous, Grégoire Michaux

Publikováno v: BioRxiv
BioRxiv, 2022, ⟨10.1101/2022.11.04.515188⟩

SummaryIntestinal microvillus atrophy is a major cause of enteropathies such as idiopathic or congenital diarrhea that are often associated with severe morbidity. It can be caused by genetic disorders, inflammatory diseases, toxins or pathogens. In p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4952918ea8e1b8d5ba0b90922c9baeac
https://hal.science/hal-03854108/document

C-terminal phosphorylation modulates ERM-1 localization and dynamics to control cortical actin organization and support lumen formation during

Autor: João J, Ramalho, Jorian J, Sepers, Ophélie, Nicolle, Ruben, Schmidt, Janine, Cravo, Grégoire, Michaux, Mike, Boxem

Publikováno v: Development (Cambridge, England). 147(14)

ERM proteins are conserved regulators of cortical membrane specialization that function as membrane-actin linkers and molecular hubs. The activity of ERM proteins requires a conformational switch from an inactive cytoplasmic form into an active membr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::5b96cb9981fc13123f2ee4d89430b713
https://pubmed.ncbi.nlm.nih.gov/32586975

A V0-ATPase-dependent apical trafficking pathway maintains the polarity of the intestinal absorptive membrane

Autor: Grégoire Michaux, Yann Le Cunff, Markus Heck, Ophélie Nicolle, Aurélien Bidaud-Meynard

Publikováno v: Development (Cambridge, England)
Development (Cambridge, England), 2019, 146 (11), pp.174508. ⟨10.1242/dev.174508⟩
Development (Cambridge, England), Company of Biologists, 2019, 146 (11), pp.174508. ⟨10.1242/dev.174508⟩
Development

Intestine function relies on the strong polarity of intestinal epithelial cells and the array of microvilli forming a brush border at their luminal pole. Combining a genetic RNA interference (RNAi) screen with in vivo super-resolution imaging in the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4dc01b2866852ccac21766c7295300ad
https://univ-rennes.hal.science/hal-02153480/document