Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Opeyemi S. Soremekun"'
Publikováno v:
Pathogens, Vol 12, Iss 4, p 591 (2023)
The sugar molecule N-glycolylneuraminic acid (Neu5Gc) is one of the most common sialic acids discovered in mammals. Cytidine monophospho-N-acetylneuraminic acid hydroxylase (CMAH) catalyses the conversion of N-acetylneuraminic acid (Neu5Ac) to Neu5Gc
Externí odkaz:
https://doaj.org/article/8b051062948f435da19ede3962afa5e0
Autor:
Opeyemi S. Soremekun, Chisom Ezenwa, Mahmoud Soliman, Tinashe Chikowore, Oyekanmi Nashiru, Segun Fatumo
Publikováno v:
Informatics in Medicine Unlocked, Vol 22, Iss , Pp 100503- (2021)
Nonsynonymous single nucleotide polymorphisms (nsSNPs) are one of the most common forms of mutations known to disrupt the product of translation thereby altering the protein structure-function relationship. GULP1 (PTB domain-containing engulfment ada
Externí odkaz:
https://doaj.org/article/5be95a3204f24666b6a0603a3b481238
Publikováno v:
Informatics in Medicine Unlocked, Vol 20, Iss , Pp 100384- (2020)
Genomic techniques such as next-generation sequencing and microarrays have facilitated the identification and classification of molecular signatures inherent in cells upon viral infection, for possible therapeutic targets. Therefore, in this study, w
Externí odkaz:
https://doaj.org/article/182a8fff20fc4368b3e667683a8d3818
Publikováno v:
Informatics in Medicine Unlocked, Vol 20, Iss , Pp 100380- (2020)
Introduction: While Pulmonary Arterial Hypertension (PAH) remains a commonly undiagnosed disease, it remains a life-threatening disease; it is characterized by pulmonary vascular remodelling subsequently leading to heart failure. Different researches
Externí odkaz:
https://doaj.org/article/f96813d5540c4b4e9ab3770917ea4d6f
Publikováno v:
Letters in Drug Design & Discovery. 19:379-386
Poly ADP-ribose polymerase-1 (PARP-1), due to its role in DNA damage and repair, has been identified as a crucial therapeutic target to attenuate cancer development and progression. More so, selective inhibition has remained a focal point in PARP-1 t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::27c635d4439a0e4af6d4293df7260eff
https://doi.org/10.2174/1570180818666210401131531
https://doi.org/10.2174/1570180818666210401131531
Publikováno v:
Current Pharmaceutical Biotechnology. 23:444-456
Background: Fragment-based drug discovery in recent times has been explored in the design of highly potent therapeutics. Methods: In this study, we explored the inhibitory dynamics of Compound 38 (Cpd38), a newly synthesized Bromodomain-containing pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5ea2d0c108a8b94e1e51cdd2c9f7cc5
https://doi.org/10.2174/1389201022666210322122056
https://doi.org/10.2174/1389201022666210322122056
Publikováno v:
Current pharmaceutical biotechnology.
Background: Parkinson’s disease (PD) is one of the most prominent neurodegenerative diseases hence the continual search for viable and effective treatment options. The pathogeny of PD is driven by many key proteins among which is the recently ident
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1aa3dbde67bae51f6e1c2820f1351f2
https://pubmed.ncbi.nlm.nih.gov/35616668
https://pubmed.ncbi.nlm.nih.gov/35616668
Publikováno v:
The Protein Journal. 40:166-174
Upregulation of Heme Oxygenase-1 (HO-1) has been widely implicated in cancer growth and chemoresistance. This explains the numerous drug discovery efforts aimed at mitigating its pro-carcinogenic roles till date. In a recent study, two selective azol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::030df39f257fc9985eca8eb25afa5f9d
https://doi.org/10.1007/s10930-021-09969-6
https://doi.org/10.1007/s10930-021-09969-6
Autor:
Adeniyi T. Adewumi, Hezekiel M. Kumalo, Opeyemi S. Soremekun, Mahmoud E. S. Soliman, Mary B. Ajadi
Publikováno v:
The Protein Journal. 40:28-40
Researches have revealed that functional non-synonymous Single Nucleotide Polymorphism (nsSNPs) present in the Zinc-finger with UFM1-Specific Peptidase domain protein (ZUFSP) may be involved in genetic instability and carcinogenesis. For the first ti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4a6895c2de601528652ef52cef1cb384
https://doi.org/10.1007/s10930-021-09962-z
https://doi.org/10.1007/s10930-021-09962-z
Autor:
Temitayo I. Subair, Opeyemi S. Soremekun, Mahmoud E. S. Soliman, Oluwole B. Akawa, Fisayo A. Olotu
Publikováno v:
RSC Advances. 11:8003-8018
Recent studies have shown that inhibition of the hSIRT2 enzyme provides favorable effects in neurodegenerative diseases such as Alzheimer's disease. Prenylated xanthone phytochemicals including α-mangostin, β-mangostin and γ-mangostin obtained fro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::53821f2faab8873431122bfbb0b85f37
https://doi.org/10.1039/d0ra10459k
https://doi.org/10.1039/d0ra10459k