Zobrazeno 1 - 10
of 178
pro vyhledávání: '"Openshaw PJ"'
Autor:
Grundmann, A, Wu, C-H, Hardwick, M, Baillie, JK, Openshaw, PJ, Semple, MG, Böhning, D, Pett, S, Michael, BD, Thomas, RH, Galea, I, ISARIC4C investigators
Publikováno v:
Baillie, J K 2022, ' Fewer COVID-19 neurological complications with dexamethasone and remdesivir ', Annals of Neurology . https://doi.org/10.1002/ana.26536
OBJECTIVE: The objective of this study was to assess the impact of treatment with dexamethasone, remdesivir or both on neurological complications in acute coronavirus diease 2019 (COVID-19).METHODS: We used observational data from the International S
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cef4c6be678d25649643b35f648f2f02
https://eprints.soton.ac.uk/472899/
https://eprints.soton.ac.uk/472899/
Innate-like gene expression of lung-resident memory CD8+ T-cells during experimental human influenza
Autor:
Paterson, S, Kar, S, Ung, SK, Gardener, Z, Bergstrom, E, Ascough, S, Kalyan, M, Zyla, J, Maertzdorf, J, Mollenkopf, H-J, Weiner, J, Jozwik, A, Jarvis, H, Jha, A, Nicholson, BP, Veldman, T, Woods, CW, Mallia, P, Kon, OM, Kaufmann, SHE, Openshaw, PJ, Chiu, C
Rationale: Suboptimal vaccine immunogenicity and antigenic mismatch, compounded by poor uptake, means that influenza remains a major global disease. T cells recognizing peptides derived from conserved viral proteins could enhance vaccine-induced cros
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______1032::5eee271a0056f1bdd932569f40115569
http://hdl.handle.net/10044/1/91411
http://hdl.handle.net/10044/1/91411
Autor:
Ascough, S, Vlachantoni, I, Kalyan, M, Haijema, B-J, Wallin-Weber, S, Dijkstra-Tiekstra, M, Ahmed, MS, Van Roosmalen, M, Grimaldi, R, Zhang, Q, Leenhouts, K, Openshaw, PJ, Chiu, C
RATIONALE: Needle-free intranasal vaccines offer major potential advantages, especially against pathogens entering via mucosal surfaces. As yet, there is no effective vaccine against respiratory syncytial virus (RSV), a ubiquitous pathogen of global
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::4cdfb7bf094b09ecccdc2c2ab6c08dd3
http://hdl.handle.net/10044/1/67135
http://hdl.handle.net/10044/1/67135
Reduced nasal viral load and IFN responses in infants with RSV bronchiolitis and respiratory failure
Autor:
Thwaites, RS, Coates, M, Ito, K, Ghazaly, M, Feather, C, Abdulla, F, Tunstall, T, Jain, P, Cass, L, Rapeport, G, Hansel, TT, Nadel, S, Openshaw, PJ
RATIONALE: Respiratory syncytial virus (RSV) bronchiolitis is a major cause of morbidity and mortality in infancy. Severe disease is thought to result from uncontrolled viral replication, an excessive immune response, or both. OBJECTIVES: To determin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______1032::69d6ec61a445d06ebcf1bc096a8bf6fc
http://hdl.handle.net/10044/1/60334
http://hdl.handle.net/10044/1/60334
Autor:
Cole, SL, Dunning, J, Kok, WL, Benam, KH, Benlahrech, A, Repapi, E, Martinez, FO, Drumright, L, Powell, TJ, Bennett, M, Elderfield, R, Thomas, C, MOSAIC investigators, Dong, T, McCauley, J, Liew, FY, Taylor, S, Zambon, M, Barclay, W, Cerundolo, V, Openshaw, PJ, McMichael, AJ, Ho, LP
In each influenza season, a distinct group of young, otherwise healthy individuals with no risk factors succumbs to life-threatening infection. To better understand the cause for this, we analyzed a broad range of immune responses in blood from a uni
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::1cc3074c14f15186630723d69f086960
https://doi.org/10.1172/jci.insight.91868
https://doi.org/10.1172/jci.insight.91868
Autor:
Thwaites, RS, Ito, K, Chingono, JMS, Coates, M, Jarvis, HC, Tunstall, T, Anderson-Dring, L, Cass, L, Rapeport, G, Openshaw, PJ, Nadel, S, Hansel, TT
Background. Existing respiratory mucosal sampling methods are flawed, particularly in a pediatric bronchiolitis setting. Methods. Twenty-four infants with bronchiolitis were recruited: 12 were respiratory syncytial virus (RSV)–positive, 12 were RSV
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______1032::1064ad262d94aceeb40c6f318cd7e785
http://hdl.handle.net/10044/1/45757
http://hdl.handle.net/10044/1/45757
Publikováno v:
PLoS ONE, Vol 11, Iss 8, p e0161885 (2016)
Respiratory Syncytial Virus (RSV) is a major pathogen causing low respiratory tract disease (bronchiolitis), primarily in infants. Helminthic infections may alter host immune responses to both helminths and to unrelated immune triggers. For example,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::499d62ee72b54c45db9b257481ce7ca7
http://europepmc.org/articles/PMC4999285?pdf=render
http://europepmc.org/articles/PMC4999285?pdf=render
Autor:
Everitt AR1, Clare S, Pertel T, John SP, Wash RS, Smith SE, Chin CR, Feeley EM, Sims JS, Adams DJ, Wise HM, Kane L, Goulding D, Digard P, Anttila V, Baillie JK, Walsh TS, Hume DA, Palotie A, Xue Y, Colonna V, Tyler-Smith C, Dunning J, Gordon SB, GenISIS Investigators, MOSAIC Investigators, Smyth RL, Openshaw PJ, Dougan G, Brass AL, Kellam P. Johnston SL, Kon OM, Everitt AR1, Clare S, Pertel T, John SP, Wash RS, Smith SE, Chin CR, Feeley EM, Sims JS, Adams DJ, Wise HM, Kane L, Goulding D, Digard P, Anttila V, Baillie JK, Walsh TS, Hume DA, Palotie A, Xue Y, Colonna V, Tyler-Smith C, Dunning J, Gordon SB, MOSAIC Investigators, Smyth RL, Openshaw PJ, Dougan G, Brass AL, Kellam P. Johnston SL, Kon OM
Publikováno v:
Nature.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=erc_________::6781be9b5eb16b142d24c60a04c821e2
Publikováno v:
Annual Congress of the British-Society-of-Immunology
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______1032::c929ca8ded8d7470ea30a909dfcaef07
http://hdl.handle.net/10044/1/19033
http://hdl.handle.net/10044/1/19033