Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Opefi, Chikwado A"'
Autor:
Opefi, Chikwado Alo
Autosomal dominant retinitis pigmentosa is a genetic disorder that leads to progressive vision loss and blindness. Over 150 AD RP mutations are located in rhodopsin; a gene that encodes the dim light photoreceptor pigment of the rod cell. Previous st
Externí odkaz:
http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.654420
Autor:
Goncalves, Joseph A., South, Kieron, Ahuja, Shivani, Zaitseva, Ekaterina, Opefi, Chikwado A., Eilers, Markus, Vogel, Reiner, Reeves, Philip J., Smith, Steven O., Henderson, Richard
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, 2010 Nov . 107(46), 19861-19866.
Externí odkaz:
https://www.jstor.org/stable/25748770
Autor:
Athanasiou, Dimitra, Aguila, Monica, Opefi, Chikwado A, South, Kieron, Bellingham, James, Bevilacqua, Dalila, Munro, Peter M, Kanuga, Naheed, Mackenzie, Francesca E, Dubis, Adam M, Georgiadis, Anastasios, Graca, Anna B, Pearson, Rachael A, Ali, Robin R, Sakami, Sanae, Palczewski, Krzysztof, Sherman, Michael Y, Reeves, Philip J, Cheetham, Michael E
Publikováno v:
Athanasiou, D, Aguila, M, Opefi, C A, South, K, Bellingham, J, Bevilacqua, D, Munro, P M, Kanuga, N, Mackenzie, F E, Dubis, A M, Georgiadis, A, Graca, A B, Pearson, R A, Ali, R R, Sakami, S, Palczewski, K, Sherman, M Y, Reeves, P J & Cheetham, M E 2017, ' Rescue of mutant rhodopsin traffic by metformin-induced AMPK activation accelerates photoreceptor degeneration ', Human Molecular Genetics, vol. 26, no. 2, pp. 305-319 . https://doi.org/10.1093/hmg/ddw387
Protein misfolding caused by inherited mutations leads to loss of protein function and potentially toxic 'gain of function', such as the dominant P23H rhodopsin mutation that causes retinitis pigmentosa (RP). Here, we tested whether the AMPK activato
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::1be46c424e0267656e40252de0f66f7b
https://eprints.kingston.ac.uk/id/eprint/39938/1/McKenzie-F-39938-VoR.pdf
https://eprints.kingston.ac.uk/id/eprint/39938/1/McKenzie-F-39938-VoR.pdf
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Autor:
Athanasiou D; UCL Institute of Ophthalmology, 11-43 Bath Street, London, UK., Aguila M; UCL Institute of Ophthalmology, 11-43 Bath Street, London, UK., Opefi CA; School of Biological Sciences, University of Essex, Wivenhoe Park, Essex, UK., South K; School of Biological Sciences, University of Essex, Wivenhoe Park, Essex, UK., Bellingham J; UCL Institute of Ophthalmology, 11-43 Bath Street, London, UK., Bevilacqua D; UCL Institute of Ophthalmology, 11-43 Bath Street, London, UK., Munro PM; UCL Institute of Ophthalmology, 11-43 Bath Street, London, UK., Kanuga N; UCL Institute of Ophthalmology, 11-43 Bath Street, London, UK., Mackenzie FE; UCL Institute of Ophthalmology, 11-43 Bath Street, London, UK., Dubis AM; Moorfields Eye Hospital NHS Trust, 162 City Road, London, UK., Georgiadis A; UCL Institute of Ophthalmology, 11-43 Bath Street, London, UK., Graca AB; UCL Institute of Ophthalmology, 11-43 Bath Street, London, UK., Pearson RA; UCL Institute of Ophthalmology, 11-43 Bath Street, London, UK., Ali RR; UCL Institute of Ophthalmology, 11-43 Bath Street, London, UK., Sakami S; Department of Pharmacology, and Cleveland Center for Membrane and Structural Biology, School of Medicine, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH, USA., Palczewski K; Department of Pharmacology, and Cleveland Center for Membrane and Structural Biology, School of Medicine, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH, USA., Sherman MY; Department of Biochemistry, Boston University Medical School, Boston, Massachusetts, MA, USA., Reeves PJ; School of Biological Sciences, University of Essex, Wivenhoe Park, Essex, UK., Cheetham ME; UCL Institute of Ophthalmology, 11-43 Bath Street, London, UK.
Publikováno v:
Human molecular genetics [Hum Mol Genet] 2017 Jan 15; Vol. 26 (2), pp. 305-319.
Construction of stable mammalian cell lines for inducible expression of G protein-coupled receptors.
Autor:
Opefi CA; Department of Biological Sciences, University of Essex, Colchester, Essex, United Kingdom., Tranter D; Department of Biological Sciences, University of Essex, Colchester, Essex, United Kingdom., Smith SO; Department of Biochemistry and Cell Biology, Stony Brook University, Stony Brook, New York, USA., Reeves PJ; Department of Biological Sciences, University of Essex, Colchester, Essex, United Kingdom. Electronic address: preeves@essex.ac.uk.
Publikováno v:
Methods in enzymology [Methods Enzymol] 2015; Vol. 556, pp. 283-305. Date of Electronic Publication: 2015 Mar 20.