A nanobody against the V-ATPase c subunit inhibits metastasis of 4T1-12B breast tumor cells to lung in mice.

Autor: Li Z; Program in Pharmacology and Drug Development, Graduate School of Biomedical Sciences, Tufts University, Boston, MA 02111, USA.; Department of Cancer Immunology and Virology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA., Alshagawi MA; Program in Pharmacology and Drug Development, Graduate School of Biomedical Sciences, Tufts University, Boston, MA 02111, USA.; Department of Pharmacology, University of Minnesota School of Medicine, MN 55455, USA., Oot RA; Department of Biochemistry and Molecular Biology, SUNY Upstate Medical University, Syracuse, NY 13210, USA., Alamoudi MK; Department of Developmental, Molecular, and Chemical Biology, Tufts University School of Medicine, Boston, MA 02111, USA.; Department of Pharmacology, College of Pharmacy, Prince Sattam Bin Abdulaziz University, Al-Kharj 11942, Saudi Arabia., Su K; Program in Pharmacology and Drug Development, Graduate School of Biomedical Sciences, Tufts University, Boston, MA 02111, USA.; Korro Bio, Cambridge, MA 02139, USA., Li W; Program in Pharmacology and Drug Development, Graduate School of Biomedical Sciences, Tufts University, Boston, MA 02111, USA., Collins MP; Program in Cellular, Molecular and Developmental Biology, Graduate School of Biomedical Sciences, Tufts University, Boston, MA 02111, USA.; Foghorn Therapeutics, Cambridge, MA 02139, USA., Wilkens S; Department of Biochemistry and Molecular Biology, SUNY Upstate Medical University, Syracuse, NY 13210, USA., Forgac M; Department of Developmental, Molecular, and Chemical Biology, Tufts University School of Medicine, Boston, MA 02111, USA.; Program in Pharmacology and Drug Development, Graduate School of Biomedical Sciences, Tufts University, Boston, MA 02111, USA.; Program in Cellular, Molecular and Developmental Biology, Graduate School of Biomedical Sciences, Tufts University, Boston, MA 02111, USA.

Publikováno v: Oncotarget [Oncotarget] 2024 Aug 14; Vol. 15, pp. 575-587. Date of Electronic Publication: 2024 Aug 14.

Tender love and disassembly: How a TLDc domain protein breaks the V-ATPase.

Autor: Wilkens S; Department of Biochemistry & Molecular Biology, SUNY Upstate Medical University, Syracuse, New York, USA., Khan MM; Department of Biochemistry & Molecular Biology, SUNY Upstate Medical University, Syracuse, New York, USA., Knight K; Department of Biochemistry & Molecular Biology, SUNY Upstate Medical University, Syracuse, New York, USA., Oot RA; Department of Biochemistry & Molecular Biology, SUNY Upstate Medical University, Syracuse, New York, USA.

Publikováno v: BioEssays : news and reviews in molecular, cellular and developmental biology [Bioessays] 2023 Jul; Vol. 45 (7), pp. e2200251. Date of Electronic Publication: 2023 May 15.

Oxidative stress protein Oxr1 promotes V-ATPase holoenzyme disassembly in catalytic activity-independent manner.

Autor: Khan MM; Department of Biochemistry and Molecular Biology, SUNY Upstate Medical University, Syracuse, NY, USA., Lee S; School of Biological Science, Institute of Molecular Biology and Genetics, Seoul National University, Seoul, South Korea., Couoh-Cardel S; Department of Biochemistry and Molecular Biology, SUNY Upstate Medical University, Syracuse, NY, USA., Oot RA; Department of Biochemistry and Molecular Biology, SUNY Upstate Medical University, Syracuse, NY, USA., Kim H; School of Biological Science, Institute of Molecular Biology and Genetics, Seoul National University, Seoul, South Korea., Wilkens S; Department of Biochemistry and Molecular Biology, SUNY Upstate Medical University, Syracuse, NY, USA., Roh SH; School of Biological Science, Institute of Molecular Biology and Genetics, Seoul National University, Seoul, South Korea.

Publikováno v: The EMBO journal [EMBO J] 2022 Feb 01; Vol. 41 (3), pp. e109360. Date of Electronic Publication: 2021 Dec 17.

A "Sugar-Coated" Proton Pump Comes into Focus: High-Resolution Structure of a Human V-ATPase.

Autor: Oot RA; SUNY Upstate Medical University, Department of Biochemistry and Molecular Biology, Syracuse, NY 13210, USA. Electronic address: ootr@upstate.edu., Wilkens S; SUNY Upstate Medical University, Department of Biochemistry and Molecular Biology, Syracuse, NY 13210, USA. Electronic address: wilkenss@upstate.edu.

Publikováno v: Molecular cell [Mol Cell] 2020 Nov 05; Vol. 80 (3), pp. 379-380.

MgATP hydrolysis destabilizes the interaction between subunit H and yeast V 1 -ATPase, highlighting H's role in V-ATPase regulation by reversible disassembly.

Autor: Sharma S; From the Department of Biochemistry and Molecular Biology, State University of New York (SUNY) Upstate Medical University, Syracuse, New York 13210., Oot RA; From the Department of Biochemistry and Molecular Biology, State University of New York (SUNY) Upstate Medical University, Syracuse, New York 13210., Wilkens S; From the Department of Biochemistry and Molecular Biology, State University of New York (SUNY) Upstate Medical University, Syracuse, New York 13210 wilkenss@upstate.edu.

Publikováno v: The Journal of biological chemistry [J Biol Chem] 2018 Jul 06; Vol. 293 (27), pp. 10718-10730. Date of Electronic Publication: 2018 May 12.