Interaction of hesperetin glucuronide conjugates with human BCRP, MRP2 and MRP3 as detected in membrane vesicles of overexpressing baculovirus-infected Sf9 cells

Autor: Brand, W., Oosterhuis, B., Krajcsi, P., Barron, D., Dionisi, F., van Bladeren, P.J., Rietjens, I., Williamson, G.

Publikováno v: Biopharmaceutics and Drug Disposition 32 (2011) 9
Biopharmaceutics and Drug Disposition, 32(9), 530-535

The citrus flavonoid hesperetin (4'-methoxy-3',5,7-trihydroxyflavanone) is the aglycone of hesperidin, the major flavonoid present in sweet oranges. Hesperetin 7-O-glucuronide (H7G) and hesperetin 3'-O-glucuronide (H3'G) are the two most abundant met

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::e00e304c0bfb13526ca0d5e2e0e25b8c
https://research.wur.nl/en/publications/interaction-of-hesperetin-glucuronide-conjugates-with-human-bcrp-

An optimized methodology for combined phenotyping and genotyping on CYP2D6 and CYP2C19

Autor: Tamminga, C.A, Wemer, J, Oosterhuis, B, Brakenhoff, J.P G, Gerrits, M.G F, de Zeeuw, R.A, de Leij, Lou, Jonkman, J.H.G.

Publikováno v: European Journal of Clinical Pharmacology, 57(2), 143-146. Springer Verlag

A method for simultaneous phenotyping and genotyping for CYP2D6 and CYP2C19 was tested. Six healthy volunteers were selected (three extensive and three poor metabolisers for CYP2D6). CYP2D6 was probed with dextromethorphan and metoprolol and CYP2C19

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=narcis______::4111471fbf686bdb43289b6f3ac493d4
https://research.rug.nl/en/publications/534b99d7-6cc1-44f3-8a8c-f6e1020c8d36

Mephenytoin as a marker for CYP2C19 enzyme activity: influence of analytical factors on teh outcome of phenotyping

Autor: Oosterhuis, B, Tamminga, W.J, Wemer, J, Wieling, J, Wilffert, B, Sakiman, E.P, de Leij, Lou, Jonkman, J.H.G., Boobis, A R, Kremers, P, Pelkonen, O, Pithan, K

Publikováno v: Proceedings European Symposium on the prediction of drug metabolism in man: progress and problems, 197-200
STARTPAGE=197;ENDPAGE=200;TITLE=Proceedings European Symposium on the prediction of drug metabolism in man: progress and problems

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=narcis______::476e03097fd84d80694624bce5a838fd
https://research.rug.nl/en/publications/5182a178-7cce-4142-98fb-b2a7b31704a1

A simple optical fiber device for quantitative fluorescence microscopy of single living cells

Autor: van Graft, M., van Graft, Marja, Oosterhuis, B., Oosterhuis, Bernard, van der Werf, Kees, de Grooth, B.G., Greve, Jan

Publikováno v: Journal of immunological methods, 159(1-2), 145-151. Elsevier

A simple and relatively inexpensive system is described for obtaining quantitative fluorescence measurements on single living cells loaded with a fluorescent probe to study cell physiological processes. The light emitted from the fluorescent cells is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::232fe24e8bacb28901a8dc15baef48e0
https://pubmed.ncbi.nlm.nih.gov/8445247

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