Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Oona Y. -C. Lee"'
Autor:
Monika Jankute, Vijayashankar Nataraj, Oona Y. -C. Lee, Houdini H. T. Wu, Malin Ridell, Natalie J. Garton, Michael R. Barer, David E. Minnikin, Apoorva Bhatt, Gurdyal S. Besra
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
Abstract The evolution of tubercle bacilli parallels a route from environmental Mycobacterium kansasii, through intermediate “Mycobacterium canettii”, to the modern Mycobacterium tuberculosis complex. Cell envelope outer membrane lipids change sy
Externí odkaz:
https://doaj.org/article/3ed2851fae5c4880a480abc5fdc8f286
Autor:
Helen D. Donoghue, G. Michael Taylor, Graham R. Stewart, Oona Y. -C. Lee, Houdini H. T. Wu, Gurdyal S. Besra, David E. Minnikin
Publikováno v:
Diversity, Vol 9, Iss 4, p 46 (2017)
Diagnosis of leprosy and tuberculosis in archaeological material is most informative when based upon entire genomes. Ancient DNA (aDNA) is often degraded but amplification of specific fragments also provides reliable diagnoses. Cell wall lipid biomar
Externí odkaz:
https://doaj.org/article/950c6f0dda754aa388e5869211fd5aa4
Publikováno v:
The Holocene. 30:781-783
The characterisation of ancient tuberculosis is not totally dependent on the recovery of intact genomes. Judicious combinations of ancient DNA fragments and specific lipid biomarkers provide unambiguous diagnosis and these protocols are capable of re
Autor:
Israel Hershkovitz, Helen D Donoghue, David E Minnikin, Gurdyal S Besra, Oona Y-C Lee, Angela M Gernaey, Ehud Galili, Vered Eshed, Charles L Greenblatt, Eshetu Lemma, Gila Kahila Bar-Gal, Mark Spigelman
Publikováno v:
PLoS ONE, Vol 3, Iss 10, p e3426 (2008)
BackgroundMycobacterium tuberculosis is the principal etiologic agent of human tuberculosis. It has no environmental reservoir and is believed to have co-evolved with its host over millennia. This is supported by skeletal evidence of the disease in e
Externí odkaz:
https://doaj.org/article/4d8500a100f249d8872d6ff5d9e6efb4
Autor:
Leen Rigouts, G. Michael Taylor, Tom A. Mendum, Houdini H.T. Wu, Graham R. Stewart, Gurdyal S. Besra, Helen D. Donoghue, David E. Minnikin, Oona Y.-C. Lee
Publikováno v:
Hansen's Disease-The Forgotten and Neglected Disease
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fb345f24aead87736d6aa234cd769c3
https://doi.org/10.5772/intechopen.75260
https://doi.org/10.5772/intechopen.75260
Publikováno v:
Chemistry and Physics of Lipids. 230:104928
Mycolic acid methyl esters were extracted from Mycobacterium avium by a mild saponification protocol, designed to preserve labile components. The resulting mixture of α-, keto- and wax ester mycolates was accompanied by some degraded ω-carboxymycol
Autor:
Ildikó Pap, Helen D. Donoghue, David E. Minnikin, Ildikó Szikossy, Houdini H.T. Wu, Oona Y.-C. Lee, Justin O'Grady, Mark Spigelman, Gurdyal S. Besra
Publikováno v:
Tuberculosis. 95:S140-S144
Many tuberculosis and leprosy infections are latent or paucibacillary, suggesting a long time-scale for host and pathogen co-existence. Palaeopathology enables recognition of archaeological cases and PCR detects pathogen ancient DNA (aDNA). Mycobacte
Autor:
Ruth McNerney, Liz E. Corbett, Reggie Mutetwa, Oona Y.-C. Lee, Nicholas W. Turner, Geraint Morgan, Denise M. O'Sullivan, David E. Minnikin, Simona Nicoara
Publikováno v:
Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
Highlights • We developed a sample clean-up method to detect tuberculosis from sputum by GC–MS. • Biomarkers recovered: 64–70% (standards solution), and 36–68% (sputum extracts). • Cholesterol removed: 93–98% (standards solution) and 62
Autor:
Andrew D. Millard, Gurdyal S. Besra, Mark J. Pallen, Helen D. Donoghue, Martin J. Sergeant, Jacqueline Z.-M. Chan, David E. Minnikin, Mark Spigelman, Oona Y.-C. Lee, Ildikó Szikossy, Ildikó Pap
Publikováno v:
Trends in Biological Anthropology. Volume 2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5b01c61ac368a7bf7c8952da49a60eca
https://doi.org/10.2307/j.ctvh1dmwc.9
https://doi.org/10.2307/j.ctvh1dmwc.9
Autor:
Grace V. O'Donovan, Oona Y.-C. Lee, Houdini H.T. Wu, Ramasamyiyer Swaminathan, Heather Milburn, Krithika Subramaniam, Mohammad Roshan Soobratty, Grace Grove, Anthony Carver, Ruth Whitfield, Graham Cope
Publikováno v:
European Respiratory Journal. 43:1519-1522
To the Editor: Good adherence to treatment for tuberculosis (TB) is essential, both to cure disease and prevent development of drug resistance. Adherence to chemoprophylaxis (preventive therapy) for latent TB infection (LTBI) is particularly poor [1]