Small-molecule-mediated OGG1 inhibition attenuates pulmonary inflammation and lung fibrosis in a murine lung fibrosis model.

Autor: Tanner L; Respiratory Medicine, Allergology, & Palliative Medicine, Department of Clinical Sciences Lund, Lund University and Skåne University Hospital, SE-221 84, Lund, Sweden. lloyd.tanner@med.lu.se., Single AB; Respiratory Medicine, Allergology, & Palliative Medicine, Department of Clinical Sciences Lund, Lund University and Skåne University Hospital, SE-221 84, Lund, Sweden., Bhongir RKV; Respiratory Medicine, Allergology, & Palliative Medicine, Department of Clinical Sciences Lund, Lund University and Skåne University Hospital, SE-221 84, Lund, Sweden., Heusel M; Division of Infection Medicine, Department of Clinical Sciences, Lund University, SE-221 84, Lund, Sweden., Mohanty T; Division of Infection Medicine, Department of Clinical Sciences, Lund University, SE-221 84, Lund, Sweden., Karlsson CAQ; Division of Infection Medicine, Department of Clinical Sciences, Lund University, SE-221 84, Lund, Sweden., Pan L; Department of Microbiology and Immunology, University of Texas Medical Branch at Galveston, Galveston, TX, 77555, USA., Clausson CM; Division of Airway Inflammation, Department of Experimental Medical Sciences, Lund University, SE-221 84, Lund, Sweden., Bergwik J; Respiratory Medicine, Allergology, & Palliative Medicine, Department of Clinical Sciences Lund, Lund University and Skåne University Hospital, SE-221 84, Lund, Sweden., Wang K; Department of Microbiology and Immunology, University of Texas Medical Branch at Galveston, Galveston, TX, 77555, USA., Andersson CK; Respiratory Cell Biology, Department of Experimental Medical Sciences Lund, Lund University, SE-221 84, Lund, Sweden., Oommen RM; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, SE-171 76, Stockholm, Sweden., Erjefält JS; Division of Airway Inflammation, Department of Experimental Medical Sciences, Lund University, SE-221 84, Lund, Sweden., Malmström J; Division of Infection Medicine, Department of Clinical Sciences, Lund University, SE-221 84, Lund, Sweden., Wallner O; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, SE-171 76, Stockholm, Sweden., Boldogh I; Department of Microbiology and Immunology, University of Texas Medical Branch at Galveston, Galveston, TX, 77555, USA., Helleday T; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, SE-171 76, Stockholm, Sweden.; Oxcia AB, Norrbackagatan 70C, SE-113 34, Stockholm, Sweden.; Weston Park Cancer Centre, Department of Oncology and Metabolism, University of Sheffield, Sheffield, S10 2RX, UK., Kalderén C; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, SE-171 76, Stockholm, Sweden.; Oxcia AB, Norrbackagatan 70C, SE-113 34, Stockholm, Sweden., Egesten A; Respiratory Medicine, Allergology, & Palliative Medicine, Department of Clinical Sciences Lund, Lund University and Skåne University Hospital, SE-221 84, Lund, Sweden.

Publikováno v: Nature communications [Nat Commun] 2023 Feb 06; Vol. 14 (1), pp. 643. Date of Electronic Publication: 2023 Feb 06.