Multicenter Validation of Histopathologic Tumor Regression Grade After Neoadjuvant Chemotherapy in Muscle-Invasive Bladder Carcinoma

Autor: Maurizio Colecchia, Peter C. Black, Laura A. Smit, Michiel S. van der Heijden, Mathilde Sibony, Morgan Rouprêt, Htoo Zarni Oo, Mads Daugaard, Charlotte S. Voskuilen, Evanguelos Xylinas, Cédric Poyet, Jean François Coté, Lorenz Buser, Kees Hendricksen, Manuel F. Meneses, Karim Saba, Jacqueline Fontugne, Alvaro Vidal, Louis Lenfant, Vera Genitsch, Marc A. Furrer, Bas W.G. van Rhijn, Andrea Necchi, Roland Seiler

Publikováno v: Voskuilen, Charlotte S; Oo, Htoo Zarni; Genitsch Gratwohl, Vera; Smit, Laura A; Vidal, Alvaro; Meneses, Manuel; Necchi, Andrea; Colecchia, Maurizio; Xylinas, Evanguelos; Fontugne, Jacqueline; Sibony, Mathilde; Rouprêt, Morgan; Lenfant, Louis; Côté, Jean-François; Buser, Lorenz; Saba, Karim; Furrer, Marc A.; van der Heijden, Michiel S; Daugaard, Mads; Black, Peter C; ... (2019). Multicenter Validation of Histopathologic Tumor Regression Grade After Neoadjuvant Chemotherapy in Muscle-Invasive Bladder Carcinoma. The American journal of surgical pathology, 43(12), pp. 1600-1610. Lippincott Williams & Wilkins 10.1097/PAS.0000000000001371
American journal of surgical pathology, 43(12), 1600-1610. Lippincott Williams and Wilkins

Response classification after neoadjuvant chemotherapy in muscle-invasive bladder carcinoma is based on the TNM stage at radical cystectomy. We recently showed that histopathologic tumor regression grades (TRGs) add prognostic information to TNM. Our

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29da7751558cb9c1969921a1546640ba

Transient CAR T cells with specificity to oncofetal glycosaminoglycans in solid tumors.

Autor: Khazamipour N; Department of Urologic Sciences, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada.; Vancouver Prostate Centre, Vancouver Coastal Health Research Institutes, Vancouver, BC, Canada., Oo HZ; Department of Urologic Sciences, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada.; Vancouver Prostate Centre, Vancouver Coastal Health Research Institutes, Vancouver, BC, Canada.; Molecular Pathology & Cell Imaging Laboratory, Vancouver Coastal Health Research Institutes, Vancouver, BC, Canada., Al-Nakouzi N; Department of Urologic Sciences, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada.; Vancouver Prostate Centre, Vancouver Coastal Health Research Institutes, Vancouver, BC, Canada., Marzban M; Vancouver Prostate Centre, Vancouver Coastal Health Research Institutes, Vancouver, BC, Canada., Khazamipour N; Department of Urologic Sciences, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada.; Vancouver Prostate Centre, Vancouver Coastal Health Research Institutes, Vancouver, BC, Canada., Roberts ME; Department of Urologic Sciences, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada.; Vancouver Prostate Centre, Vancouver Coastal Health Research Institutes, Vancouver, BC, Canada., Farivar N; Department of Urologic Sciences, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada.; Vancouver Prostate Centre, Vancouver Coastal Health Research Institutes, Vancouver, BC, Canada., Moskalev I; Vancouver Prostate Centre, Vancouver Coastal Health Research Institutes, Vancouver, BC, Canada., Lo J; Vancouver Prostate Centre, Vancouver Coastal Health Research Institutes, Vancouver, BC, Canada., Ghaidi F; Vancouver Prostate Centre, Vancouver Coastal Health Research Institutes, Vancouver, BC, Canada., Nelepcu I; Vancouver Prostate Centre, Vancouver Coastal Health Research Institutes, Vancouver, BC, Canada., Moeen A; Vancouver Prostate Centre, Vancouver Coastal Health Research Institutes, Vancouver, BC, Canada., Truong S; Vancouver Prostate Centre, Vancouver Coastal Health Research Institutes, Vancouver, BC, Canada., Dagil R; Centre for Translational Medicine and Parasitology at Department for Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen University Hospital, Copenhagen, Denmark.; VAR2 Pharmaceuticals ApS, Copenhagen, Denmark., Choudhary S; Centre for Translational Medicine and Parasitology at Department for Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen University Hospital, Copenhagen, Denmark.; VAR2 Pharmaceuticals ApS, Copenhagen, Denmark., Gustavsson T; Centre for Translational Medicine and Parasitology at Department for Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen University Hospital, Copenhagen, Denmark.; VAR2 Pharmaceuticals ApS, Copenhagen, Denmark., Zhai B; Department of Urologic Sciences, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada.; Vancouver Prostate Centre, Vancouver Coastal Health Research Institutes, Vancouver, BC, Canada., Heitzender S; Division of Pediatric Hematology/Oncology/Stem Cell Transplantation and Regenerative Medicine, Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA, USA., Salanti A; Centre for Translational Medicine and Parasitology at Department for Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen University Hospital, Copenhagen, Denmark.; VAR2 Pharmaceuticals ApS, Copenhagen, Denmark., Sorensen PH; VAR2 Pharmaceuticals ApS, Copenhagen, Denmark.; Department of Molecular Oncology, British Columbia Cancer Research Centre, Vancouver, BC, Canada.; Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada., Daugaard M; Department of Urologic Sciences, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada. mads.daugaard@ubc.ca.; Vancouver Prostate Centre, Vancouver Coastal Health Research Institutes, Vancouver, BC, Canada. mads.daugaard@ubc.ca.; Molecular Pathology & Cell Imaging Laboratory, Vancouver Coastal Health Research Institutes, Vancouver, BC, Canada. mads.daugaard@ubc.ca.; VAR2 Pharmaceuticals ApS, Copenhagen, Denmark. mads.daugaard@ubc.ca.

Publikováno v: EMBO molecular medicine [EMBO Mol Med] 2024 Nov; Vol. 16 (11), pp. 2775-2794. Date of Electronic Publication: 2024 Oct 15.

Tumor-agnostic cancer therapy using antibodies targeting oncofetal chondroitin sulfate.

Autor: Vidal-Calvo EE; Centre for Translational Medicine and Parasitology, Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen University Hospital, Copenhagen, Denmark. elena@sund.ku.dk.; VAR2 Pharmaceuticals ApS, Copenhagen, Denmark. elena@sund.ku.dk., Martin-Salazar A; Centre for Translational Medicine and Parasitology, Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen University Hospital, Copenhagen, Denmark., Choudhary S; Centre for Translational Medicine and Parasitology, Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen University Hospital, Copenhagen, Denmark.; VAR2 Pharmaceuticals ApS, Copenhagen, Denmark., Dagil R; Centre for Translational Medicine and Parasitology, Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen University Hospital, Copenhagen, Denmark.; VAR2 Pharmaceuticals ApS, Copenhagen, Denmark., Raghavan SSR; Centre for Translational Medicine and Parasitology, Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen University Hospital, Copenhagen, Denmark., Duvnjak L; Centre for Translational Medicine and Parasitology, Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen University Hospital, Copenhagen, Denmark.; VAR2 Pharmaceuticals ApS, Copenhagen, Denmark., Nordmaj MA; Centre for Translational Medicine and Parasitology, Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen University Hospital, Copenhagen, Denmark., Clausen TM; VAR2 Pharmaceuticals ApS, Copenhagen, Denmark., Skafte A; Centre for Translational Medicine and Parasitology, Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen University Hospital, Copenhagen, Denmark.; VAR2 Pharmaceuticals ApS, Copenhagen, Denmark., Oberkofler J; Centre for Translational Medicine and Parasitology, Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen University Hospital, Copenhagen, Denmark., Wang K; Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Agerbæk MØ; Centre for Translational Medicine and Parasitology, Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen University Hospital, Copenhagen, Denmark.; VARCT Diagnostics, Copenhagen, Denmark., Løppke C; Centre for Translational Medicine and Parasitology, Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen University Hospital, Copenhagen, Denmark., Jørgensen AM; Centre for Translational Medicine and Parasitology, Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen University Hospital, Copenhagen, Denmark.; VARCT Diagnostics, Copenhagen, Denmark., Ropac D; Centre for Translational Medicine and Parasitology, Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen University Hospital, Copenhagen, Denmark., Mujollari J; Centre for Translational Medicine and Parasitology, Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen University Hospital, Copenhagen, Denmark., Willis S; Centre for Translational Medicine and Parasitology, Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen University Hospital, Copenhagen, Denmark., Garcias López A; Centre for Translational Medicine and Parasitology, Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen University Hospital, Copenhagen, Denmark., Miller RL; Copenhagen Center for Glycomics, Department of Cellular and Molecular Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Karlsson RTG; Copenhagen Center for Glycomics, Department of Cellular and Molecular Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Goerdeler F; Copenhagen Center for Glycomics, Department of Cellular and Molecular Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Chen YH; GlycoDisplay ApS, Copenhagen, Denmark., Colaço AR; Proteomics Research Infrastructure, University of Copenhagen, Copenhagen, Denmark., Wang Y; College of Life Sciences, Zhejiang University, Hangzhou, China., Lavstsen T; Centre for Translational Medicine and Parasitology, Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen University Hospital, Copenhagen, Denmark., Martowicz A; Department of Internal Medicine V, Haematology & Oncology, Comprehensive Cancer Center Innsbruck (CCCI) and Tyrolean Cancer Research Institute (TKFI), Medical University of Innsbruck, Innsbruck, Austria., Nelepcu I; Vancouver Prostate Centre, Vancouver Coastal Health Research Institutes, Vancouver, BC, Canada.; Department of Urologic Sciences, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada., Marzban M; Vancouver Prostate Centre, Vancouver Coastal Health Research Institutes, Vancouver, BC, Canada.; Department of Urologic Sciences, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada., Oo HZ; Vancouver Prostate Centre, Vancouver Coastal Health Research Institutes, Vancouver, BC, Canada.; Department of Urologic Sciences, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada., Ørum-Madsen MS; Vancouver Prostate Centre, Vancouver Coastal Health Research Institutes, Vancouver, BC, Canada.; Department of Urologic Sciences, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada., Wang Y; Vancouver Prostate Centre, Vancouver Coastal Health Research Institutes, Vancouver, BC, Canada., Nielsen MA; Centre for Translational Medicine and Parasitology, Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen University Hospital, Copenhagen, Denmark.; VAR2 Pharmaceuticals ApS, Copenhagen, Denmark., Clausen H; Copenhagen Center for Glycomics, Department of Cellular and Molecular Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Wierer M; Proteomics Research Infrastructure, University of Copenhagen, Copenhagen, Denmark., Wolf D; Department of Internal Medicine V, Haematology & Oncology, Comprehensive Cancer Center Innsbruck (CCCI) and Tyrolean Cancer Research Institute (TKFI), Medical University of Innsbruck, Innsbruck, Austria., Gögenur I; Center for Surgical Science, Department of Surgery, Zealand University Hospital Køge, Køge, Denmark., Theander TG; Centre for Translational Medicine and Parasitology, Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen University Hospital, Copenhagen, Denmark.; VAR2 Pharmaceuticals ApS, Copenhagen, Denmark., Al-Nakouzi N; VAR2 Pharmaceuticals ApS, Copenhagen, Denmark.; Vancouver Prostate Centre, Vancouver Coastal Health Research Institutes, Vancouver, BC, Canada.; Department of Urologic Sciences, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada., Gustavsson T; Centre for Translational Medicine and Parasitology, Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen University Hospital, Copenhagen, Denmark.; VAR2 Pharmaceuticals ApS, Copenhagen, Denmark., Daugaard M; VAR2 Pharmaceuticals ApS, Copenhagen, Denmark. mads.daugaard@ubc.ca.; Vancouver Prostate Centre, Vancouver Coastal Health Research Institutes, Vancouver, BC, Canada. mads.daugaard@ubc.ca.; Department of Urologic Sciences, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada. mads.daugaard@ubc.ca., Salanti A; Centre for Translational Medicine and Parasitology, Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen University Hospital, Copenhagen, Denmark. salanti@sund.ku.dk.; VAR2 Pharmaceuticals ApS, Copenhagen, Denmark. salanti@sund.ku.dk.

Publikováno v: Nature communications [Nat Commun] 2024 Aug 30; Vol. 15 (1), pp. 7553. Date of Electronic Publication: 2024 Aug 30.

USP11 promotes prostate cancer progression by up-regulating AR and c-Myc activity.

Autor: Pornour M; Department of Biochemistry and Molecular Biology, University of Maryland, Baltimore, MD 21201.; Marlene and Stewart Greenebaum Comprehensive Cancer Center, Baltimore, MD 21201., Jeon HY; Department of Biochemistry and Molecular Biology, University of Maryland, Baltimore, MD 21201.; Marlene and Stewart Greenebaum Comprehensive Cancer Center, Baltimore, MD 21201., Ryu H; Department of Biochemistry and Molecular Biology, University of Maryland, Baltimore, MD 21201.; Marlene and Stewart Greenebaum Comprehensive Cancer Center, Baltimore, MD 21201., Khadka S; Department of Biochemistry and Molecular Biology, University of Maryland, Baltimore, MD 21201.; Marlene and Stewart Greenebaum Comprehensive Cancer Center, Baltimore, MD 21201., Xu R; Department of Biochemistry and Molecular Biology, University of Maryland, Baltimore, MD 21201.; Department of Marine Biotechnology, Institute of Marine and Environmental Technology, University of Maryland, Baltimore, MD 21202., Chen H; Department of Epidemiology and Public Health, University of Maryland, Baltimore, MD 21201., Hussain A; Department of Biochemistry and Molecular Biology, University of Maryland, Baltimore, MD 21201.; Marlene and Stewart Greenebaum Comprehensive Cancer Center, Baltimore, MD 21201.; Baltimore Veterans Affairs Medical Center, Baltimore, MD 21201., Lam HM; Department of Urology, University of Washington, Seattle, WA 98195., Zhuang Z; Department of Chemistry and Biochemistry, University of Delaware, Newark, DE 19716., Oo HZ; Department of Urologic Sciences, Vancouver Prostate Centre, University of British Columbia, Vancouver, BC V6H 3Z6, Canada., Gleave M; Department of Urologic Sciences, Vancouver Prostate Centre, University of British Columbia, Vancouver, BC V6H 3Z6, Canada., Dong X; Department of Urologic Sciences, Vancouver Prostate Centre, University of British Columbia, Vancouver, BC V6H 3Z6, Canada., Wang Q; Department of Pathology and Duke Cancer Institute, Duke University School of Medicine, Durham, NC 27710., Barbieri C; Department of Urology, Weill Cornell Medical College, Cornell University, New York, NY 10065., Qi J; Department of Biochemistry and Molecular Biology, University of Maryland, Baltimore, MD 21201.; Marlene and Stewart Greenebaum Comprehensive Cancer Center, Baltimore, MD 21201.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2024 Jul 30; Vol. 121 (31), pp. e2403331121. Date of Electronic Publication: 2024 Jul 25.

A Bifunctional PARP-HDAC Inhibitor with Activity in Ewing Sarcoma.

Autor: Ramos L; Department of Urologic Sciences, University of British Columbia, Vancouver, British Columbia, Canada.; Vancouver Prostate Centre, Vancouver, British Columbia, Canada.; Rakovina Therapeutics, Vancouver, British Columbia, Canada., Truong S; Vancouver Prostate Centre, Vancouver, British Columbia, Canada.; Rakovina Therapeutics, Vancouver, British Columbia, Canada., Zhai B; Department of Urologic Sciences, University of British Columbia, Vancouver, British Columbia, Canada.; Vancouver Prostate Centre, Vancouver, British Columbia, Canada.; Rakovina Therapeutics, Vancouver, British Columbia, Canada., Joshi J; Vancouver Prostate Centre, Vancouver, British Columbia, Canada.; Rakovina Therapeutics, Vancouver, British Columbia, Canada., Ghaidi F; Vancouver Prostate Centre, Vancouver, British Columbia, Canada.; Rakovina Therapeutics, Vancouver, British Columbia, Canada., Lizardo MM; BC Cancer Agency, Vancouver, British Columbia, Canada., Shyp T; BC Cancer Agency, Vancouver, British Columbia, Canada.; Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, Canada., Kung SHY; Vancouver Prostate Centre, Vancouver, British Columbia, Canada., Rezakhanlou AM; Vancouver Prostate Centre, Vancouver, British Columbia, Canada., Oo HZ; Vancouver Prostate Centre, Vancouver, British Columbia, Canada., Adomat H; Vancouver Prostate Centre, Vancouver, British Columbia, Canada., Le Bihan S; Vancouver Prostate Centre, Vancouver, British Columbia, Canada., Collins C; Department of Urologic Sciences, University of British Columbia, Vancouver, British Columbia, Canada.; Vancouver Prostate Centre, Vancouver, British Columbia, Canada., Bacha J; Rakovina Therapeutics, Vancouver, British Columbia, Canada., Brown D; Rakovina Therapeutics, Vancouver, British Columbia, Canada., Langlands J; Rakovina Therapeutics, Vancouver, British Columbia, Canada., Shen W; Rakovina Therapeutics, Vancouver, British Columbia, Canada., Lallous N; Department of Urologic Sciences, University of British Columbia, Vancouver, British Columbia, Canada.; Vancouver Prostate Centre, Vancouver, British Columbia, Canada., Sorensen PH; BC Cancer Agency, Vancouver, British Columbia, Canada.; Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, Canada., Daugaard M; Department of Urologic Sciences, University of British Columbia, Vancouver, British Columbia, Canada.; Vancouver Prostate Centre, Vancouver, British Columbia, Canada.; Rakovina Therapeutics, Vancouver, British Columbia, Canada.; Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, Canada.

Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research [Clin Cancer Res] 2023 Sep 01; Vol. 29 (17), pp. 3541-3553.