Zobrazeno 1 - 10
of 135
pro vyhledávání: '"Onur, Boyman"'
Autor:
Yoshito Yamada, Tuan Thanh Nguyen, Daniela Impellizzieri, Katsutaka Mineura, Rintaro Shibuya, Alvaro Gomariz, Martina Haberecker, Jakob Nilsson, César Nombela-Arrieta, Wolfgang Jungraithmayr, Onur Boyman
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
IL-2/anti-IL-2 antibody complexes have been shown to facilitate the process of graft acceptance in transplantation. Here the authors use a mouse allograft model to show that IL-2 complexes promote graft acceptance and formation of inducible lymphoid
Externí odkaz:
https://doaj.org/article/abc4262f8d2243d49d3da3a6fedb78d8
Publikováno v:
EBioMedicine, Vol 90, Iss , Pp 104539- (2023)
Summary: Background: The cytokine interleukin-2 (IL-2) can stimulate both effector immune cells and regulatory T (Treg) cells. The ability of selectively engaging either of these effects has spurred interest in using IL-2 for immunotherapy of cancer
Externí odkaz:
https://doaj.org/article/6f24eb0b735344ddbb97e4d54971d983
Autor:
Alexandar Tzankov, Nicole Joller, Onur Boyman, Anne Müller, Kristin Stirm, Peter Leary, Daria Wüst, Dominique Stark, Ufuk Karakus
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss 2 (2023)
Background Roughly half of all diffuse large B-cell lymphomas (DLBCLs) are infiltrated by large numbers of regulatory T-cells (Tregs). Although the presence of ‘effector’ Tregs in particular is associated with an inferior prognosis in patients on
Externí odkaz:
https://doaj.org/article/19fcfd9206c14d5299cc560537d38cce
Autor:
Marc Emmenegger, Elena De Cecco, David Lamparter, Raphaël P.B. Jacquat, Julien Riou, Dominik Menges, Tala Ballouz, Daniel Ebner, Matthias M. Schneider, Itzel Condado Morales, Berre Doğançay, Jingjing Guo, Anne Wiedmer, Julie Domange, Marigona Imeri, Rita Moos, Chryssa Zografou, Leyla Batkitar, Lidia Madrigal, Dezirae Schneider, Chiara Trevisan, Andres Gonzalez-Guerra, Alessandra Carrella, Irina L. Dubach, Catherine K. Xu, Georg Meisl, Vasilis Kosmoliaptsis, Tomas Malinauskas, Nicola Burgess-Brown, Ray Owens, Stephanie Hatch, Juthathip Mongkolsapaya, Gavin R. Screaton, Katharina Schubert, John D. Huck, Feimei Liu, Florence Pojer, Kelvin Lau, David Hacker, Elsbeth Probst-Müller, Carlo Cervia, Jakob Nilsson, Onur Boyman, Lanja Saleh, Katharina Spanaus, Arnold von Eckardstein, Dominik J. Schaer, Nenad Ban, Ching-Ju Tsai, Jacopo Marino, Gebhard F.X. Schertler, Nadine Ebert, Volker Thiel, Jochen Gottschalk, Beat M. Frey, Regina R. Reimann, Simone Hornemann, Aaron M. Ring, Tuomas P.J. Knowles, Milo A. Puhan, Christian L. Althaus, Ioannis Xenarios, David I. Stuart, Adriano Aguzzi
Publikováno v:
iScience, Vol 26, Iss 2, Pp 105928- (2023)
Summary: Effective public health measures against SARS-CoV-2 require granular knowledge of population-level immune responses. We developed a Tripartite Automated Blood Immunoassay (TRABI) to assess the IgG response against three SARS-CoV-2 proteins.
Externí odkaz:
https://doaj.org/article/bea10cd3141c4742a1c82d8153f04eb2
Autor:
Carlo Cervia, Yves Zurbuchen, Patrick Taeschler, Tala Ballouz, Dominik Menges, Sara Hasler, Sarah Adamo, Miro E. Raeber, Esther Bächli, Alain Rudiger, Melina Stüssi-Helbling, Lars C. Huber, Jakob Nilsson, Ulrike Held, Milo A. Puhan, Onur Boyman
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
Studying a prospective cohort, the authors develop and validate a predictive score for post-acute COVID-19 syndrome, also known as long-COVID. This score relies on an immunoglobulin signature and is independent of timepoint of blood sampling.
Externí odkaz:
https://doaj.org/article/79cffcd777124d548463576add3f9a75
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
BackgroundThe cytokine interleukin (IL)-1 plays a pivotal role in immune-mediated disorders, particularly in autoinflammatory diseases. Targeting this cytokine proved to be efficacious in treating numerous IL-1-mediated pathologies. Currently, three
Externí odkaz:
https://doaj.org/article/5598cba60f3c4dc3805be2568e4f732a
Autor:
Dilara Sahin, Natalia Arenas-Ramirez, Matthias Rath, Ufuk Karakus, Monika Hümbelin, Merel van Gogh, Lubor Borsig, Onur Boyman
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
IL-2/anti-IL-2 complexes have been proposed to curtail the severe adverse effects associated with IL-2 immunotherapy. Here, the authors, by integrating unmutated human IL-2 in the antigen binding groove of an anti-IL-2 monoclonal antibody, generate a
Externí odkaz:
https://doaj.org/article/bccae141645e49d6828a1fe5efe66a25
Autor:
Ilana Reinhold, Sena Blümel, Jens Schreiner, Onur Boyman, Jan Bögeholz, Marcus Cheetham, Gerhard Rogler, Luc Biedermann, Michael Scharl
Publikováno v:
Inflammatory Intestinal Diseases, Pp 1-10 (2020)
Background and Aims: The majority of patients treated with anti-tumor necrosis factor (TNF) therapy develop anti-drug antibodies (ADAs), which might result in loss of treatment efficacy. Strict guidelines on measuring trough levels (TLs) and ADA in c
Externí odkaz:
https://doaj.org/article/a072f0b8ec674099b08f26b40c8fe964
Publikováno v:
Frontiers in Immunology, Vol 12 (2022)
BackgroundB cells can contribute to immune-mediated disorders. Targeting CD20 has proved to be efficacious in several B cell-mediated immunopathologies, as illustrated by the use of rituximab, the first anti-CD20 monoclonal antibody (mAb). Following
Externí odkaz:
https://doaj.org/article/9aaac02babe6479b97d8671f61b9d03f
Autor:
Michelle Schorer, Katharina Lambert, Nikolas Rakebrandt, Felix Rost, Kung-Chi Kao, Alexander Yermanos, Roman Spörri, Josua Oderbolz, Miro E. Raeber, Christian W. Keller, Jan D. Lünemann, Gerhard Rogler, Onur Boyman, Annette Oxenius, Nicole Joller
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Viral infection transiently depletes T regulatory cells (Treg). Here the authors identify a compensatory induced Treg population, which is required to rapidly replenish the Treg niche and suppress microbiota-driven, virus-induced colitis.
Externí odkaz:
https://doaj.org/article/358d973756854a01949a43086610135a