Mertensene, a Halogenated Monoterpene, Induces G2/M Cell Cycle Arrest and Caspase Dependent Apoptosis of Human Colon Adenocarcinoma HT29 Cell Line through the Modulation of ERK-1/-2, AKT and NF-κB Signaling

Autor: Safa Tarhouni-Jabberi, Ons Zakraoui, Efstathia Ioannou, Ichrak Riahi-Chebbi, Meriam Haoues, Vassilios Roussis, Riadh Kharrat, Khadija Essafi-Benkhadir

Publikováno v: Marine Drugs, Vol 15, Iss 7, p 221 (2017)

Conventional treatment of advanced colorectal cancer is associated with tumor resistance and toxicity towards normal tissues. Therefore, development of effective anticancer therapeutic alternatives is still urgently required. Nowadays, marine seconda

Externí odkaz: https://doaj.org/article/be737c4a0df84520841f15d93398fa12

Lebecetin, a snake venom C-type lectin protein, modulates LPS-induced inflammatory cytokine production in human THP-1-derived macrophages

Autor: Dorra Aissaoui, Najet Srairi-Abid, Khadija Essafi-Benkhadir, Naziha Marrakchi, Ons Zakraoui, Zaineb Abdelkafi-Koubaa, Jed Jebali

Publikováno v: Toxicon : official journal of the International Society on Toxinology. 187

The excessive production of inflammatory mediators results in an overactive immune response leading to the worsening of various human diseases. Thus, there is a still need to identify molecules able to regulate the inflammatory response. Lebecetin, a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4155d90e326fb48292827977c59e6a0
https://pubmed.ncbi.nlm.nih.gov/32918926

Identification of novel leishmanicidal molecules by virtual and biochemical screenings targeting Leishmania eukaryotic translation initiation factor 4A

Autor: Imen Bassoumi-Jamoussi, Guillaume Bouvier, Michael Nilges, Mourad Barhoumi, N. Kyle Tanner, Josette Banroques, Arnaud Blondel, Ikram Guizani, Nathan Desdouits, Khadija Essafi-Benkhadir, Hélène Munier-Lehmann, Emna Harigua-Souiai, Yosser Zina Abdelkrim, Ons Zakraoui

Publikováno v: PLoS Neglected Tropical Diseases
PLoS Neglected Tropical Diseases, Public Library of Science, 2018, 12 (1), pp.e0006160. ⟨10.1371/journal.pntd.0006160⟩
PLoS Neglected Tropical Diseases, 2018, 12 (1), pp.e0006160. ⟨10.1371/journal.pntd.0006160⟩
PLoS Neglected Tropical Diseases, Vol 12, Iss 1, p e0006160 (2018)

Leishmaniases are neglected parasitic diseases in spite of the major burden they inflict on public health. The identification of novel drugs and targets constitutes a research priority. For that purpose we used Leishmania infantum initiation factor 4

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0672f598131f3a814de19e5a2c66f228
https://hal-pasteur.archives-ouvertes.fr/pasteur-01968424

Lebein, a Snake Venom Disintegrin, Induces Apoptosis in Human Melanoma Cells

Autor: Zohra Aloui, Khadija Essafi-Benkhadir, Ons Zakraoui, María F. Montenegro, Luis Sánchez-del-Campo, Habib Karoui, Manel B Hammouda, José Neptuno Rodríguez-López, Ichrak Riahi-Chebbi

Publikováno v: Toxins
Toxins, MDPI, 2016, 8 (7), ⟨10.3390/toxins8070206⟩
Toxins, Vol 8, Iss 7, p 206 (2016)
Toxins; Volume 8; Issue 7; Pages: 206

International audience; Melanoma, the most threatening form of skin cancer, has a very poor prognosis and is characterized by its very invasive and chemoresistant properties. Despite the recent promising news from the field of immunotherapy, there is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6131337b2f67da725134d6ad57d726a
https://hal-riip.archives-ouvertes.fr/pasteur-01374990

Lebein, a snake venom disintegrin, suppresses human colon cancer cells proliferation and tumor-induced angiogenesis through cell cycle arrest, apoptosis induction and inhibition of VEGF expression

Autor: Ons, Zakraoui, Cezary, Marcinkiewicz, Zohra, Aloui, Houcemeddine, Othman, Renaud, Grépin, Meriam, Haoues, Makram, Essafi, Najet, Srairi-Abid, Ammar, Gasmi, Habib, Karoui, Gilles, Pagès, Khadija, Essafi-Benkhadir

Publikováno v: Molecular Carcinogenesis
Molecular Carcinogenesis, Wiley, 2016, 56, pp.18-35. ⟨10.1002/mc.22470⟩

Lebein, is an heterodimeric disintegrin isolated from Macrovipera lebetina snake venom that was previously characterized as an inhibitor of ADP-induced platelet aggregation. In this study, we investigated the effect of Lebein on the p53-dependent gro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::0f26039872eae3cfc403bba0d6257ac7
https://hal.archives-ouvertes.fr/hal-01356511