Sphingosine‐1‐phosphate controls endothelial sphingolipid homeostasis via ORMDL

Autor: Linda Sasset, Kamrul H Chowdhury, Onorina L Manzo, Luisa Rubinelli, Csaba Konrad, J Alan Maschek, Giovanni Manfredi, William L Holland, Annarita Di Lorenzo

Publikováno v: EMBO reports. 24

Disruption of sphingolipid homeostasis and signaling has been implicated in diabetes, cancer, cardiometabolic, and neurodegenerative disorders. Yet, mechanisms governing cellular sensing and regulation of sphingolipid homeostasis remain largely unkno

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f92d7d10691858b096e2a5d98e8225f9
https://doi.org/10.15252/embr.202254689

S1P controls endothelial sphingolipid homeostasis via ORMDL

Autor: Linda Sasset, Kamrul H. Chowdhury, Onorina L. Manzo, Luisa Rubinelli, Csaba Konrad, J. A. Maschek, Giovanni Manfredi, William L. Holland, Annarita Di Lorenzo

Publikováno v: The FASEB Journal. 36

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0d3b821e0ae1aadffa8b4c6e6e8f49c9
https://doi.org/10.1096/fasebj.2022.36.s1.r5883

Duchenne's muscular dystrophy involves a defective transsulfuration pathway activity

Autor: Valentina Vellecco, Giuseppe Cirino, Elisabetta Panza, D. Paris, Fabio Arturo Iannotti, G. de Dominicis, Mariarosaria Bucci, Onorina L. Manzo, A. Boscaino, M. Smimmo, A. Di Lorenzo, N. Mitilini

Publikováno v: Redox Biology, Vol 45, Iss, Pp 102040-(2021)
Redox Biology
RedoxBiology 45 (2021). doi:10.1016/j.redox.2021.102040
info:cnr-pdr/source/autori:Panza E.; Vellecco V.; Iannotti F.A.; Paris D.; Manzo O.L.; Smimmo M.; Mitilini N.; Boscaino A.; de Dominicis G.; Bucci M.; Di Lorenzo A.; Cirino G./titolo:Duchenne's muscular dystrophy involves a defective transsulfuration pathway activity/doi:10.1016%2Fj.redox.2021.102040/rivista:RedoxBiology/anno:2021/pagina_da:/pagina_a:/intervallo_pagine:/volume:45

Duchenne muscular dystrophy (DMD) is the most frequent X chromosome-linked disease caused by mutations in the gene encoding for dystrophin, leading to progressive and unstoppable degeneration of skeletal muscle tissues. Despite recent advances in the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae7632bb0ee4507440b44c46b734c6f5
http://www.sciencedirect.com/science/article/pii/S2213231721001993

Erucin exhibits vasorelaxing effects and antihypertensive activity by H 2 S-releasing properties

Autor: Eleonora Pagnotta, Lara Testai, Luisa Ugolini, Onorina L. Manzo, Mariarosaria Bucci, Lorenzo Di Cesare Mannelli, Eugenia Piragine, Maria Cristina Breschi, Valentina Citi, Luca Lazzeri, Alma Martelli, Carla Ghelardini, Vincenzo Calderone

Publikováno v: Br J Pharmacol

BACKGROUND AND PURPOSE: Hydrogen sulfide (H(2)S)‐releasing agents are viewed as potential antihypertensive drugs. Recently, natural isothiocyanates emerged as original H(2)S‐donor agents. Among them, erucin, present in some edible cruciferous pla

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e19517afc215364cdb7497729d867ca2
http://hdl.handle.net/11568/990113

Anomalous K

Autor: Valentina, Vellecco, Alma, Martelli, Iris Sofia, Bibli, Marianna, Vallifuoco, Onorina L, Manzo, Elisabetta, Panza, Valentina, Citi, Vincenzo, Calderone, Gianfranco, de Dominicis, Caterina, Cozzolino, Elisabetta M, Basso, Martina, Mariniello, Ingrid, Fleming, Antonio, Mancini, Mariarosaria, Bucci, Giuseppe, Cirino

Publikováno v: Br J Pharmacol

BACKGROUND AND PURPOSE: Human malignant hyperthermia (MH) syndrome is induced by volatile anaesthetics and involves increased levels of cystathionine β‐synthase (CBS)‐derived H(2)S within skeletal muscle. This increase contributes to skeletal mu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e59ce28316f227c2e256b2e7e8b066fe
https://pubmed.ncbi.nlm.nih.gov/31051045