Zobrazeno 1 - 10
of 76
pro vyhledávání: '"Onofrio, Laselva"'
Publikováno v:
Frontiers in Molecular Biosciences, Vol 11 (2024)
Externí odkaz:
https://doaj.org/article/b86297f9fb83412299fac5f5f875e248
Autor:
Md Niamat Hossain, Vincenzo De Leo, Rosanna Tamborra, Onofrio Laselva, Chiara Ingrosso, Valeria Daniello, Lucia Catucci, Ilario Losito, Francesco Sollitto, Domenico Loizzi, Massimo Conese, Sante Di Gioia
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)
Abstract In this in vitro study, we test our hypothesis that Broccoli-derived vesicles (BDVs), combining the anti-oxidant properties of their components and the advantages of their structure, can influence the metabolic activity of different cancer c
Externí odkaz:
https://doaj.org/article/77a7836a153a4ed1bf9e55d2ebfe287d
Autor:
Mina Ogawa, Jia-Xin Jiang, Sunny Xia, Donghe Yang, Avrilynn Ding, Onofrio Laselva, Marcela Hernandez, Changyi Cui, Yuichiro Higuchi, Hiroshi Suemizu, Craig Dorrell, Markus Grompe, Christine E. Bear, Shinichiro Ogawa
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
Current protocols to generate cholangiocytes from human pluripotent cells produce immature cells. Here the authors identify retinoic acid, BMP, cAMP and Rho kinase pathways as regulators of cholangiocyte maturation, and generate ciliated cholangiocyt
Externí odkaz:
https://doaj.org/article/e2c37e554f8c4d829b4039f62abf625f
Autor:
Onofrio Laselva, Massimo Conese
Publikováno v:
Journal of Respiration, Vol 1, Iss 4, Pp 229-247 (2021)
Cystic fibrosis (CF) is an autosomal recessive multi-organ disease caused by mutations in the CF Transmembrane Conductance Regulator (CFTR) gene, with morbidity and mortality primacy related to the lung disease. The CFTR protein, a chloride/bicarbona
Externí odkaz:
https://doaj.org/article/9be03c79acaa407199911681b6a34fb0
Publikováno v:
Cells, Vol 12, Iss 13, p 1764 (2023)
The deletion of phenylalanine at position 508 (F508del) produces a misfolded CFTR protein that is retained in the ER and degraded. The lack of normal CFTR channel activity is associated with chronic infection and inflammation which are the primary ca
Externí odkaz:
https://doaj.org/article/e065606b5db847c29555e183a70b3565
Autor:
Onofrio Laselva, Maria Laura Criscione, Caterina Allegretta, Sante Di Gioia, Arcangelo Liso, Massimo Conese
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2022)
Cystic Fibrosis (CF) patients are prone to contracting bacterial lung infections with opportunistic pathogens, especially Pseudomonas aeruginosa. Prolonged P. aeruginosa infections have been linked to chronic inflammation in the CF lung, whose hallma
Externí odkaz:
https://doaj.org/article/6847cf4eaf9646f79f44232024cf0ffa
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2022)
Externí odkaz:
https://doaj.org/article/a97aa94a9e1c45a7854c2c0302a77cae
Autor:
Onofrio Laselva, Evgeniy V. Petrotchenko, C. Michael Hamilton, Zafar Qureshi, Christoph H. Borchers, Robert N. Young, Christine E. Bear
Publikováno v:
STAR Protocols, Vol 3, Iss 2, Pp 101258- (2022)
Summary: We describe a protocol to identify the binding site(s) for a drug called ivacaftor that potentiates the CFTR chloride channel. We use photoaffinity probes—based on the structure of ivacaftor—to covalently modify the CFTR protein at the r
Externí odkaz:
https://doaj.org/article/d780e2dbabf949ef8626b66fff79d3bc
Autor:
Santina Venuto, Anna Rita Daniela Coda, Ruperto González-Pérez, Onofrio Laselva, Doron Tolomeo, Clelia Tiziana Storlazzi, Arcangelo Liso, Massimo Conese
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 5, p 4804 (2023)
The lung is an accomplished organ for gas exchanges and directly faces the external environment, consequently exposing its large epithelial surface. It is also the putative determinant organ for inducing potent immune responses, holding both innate a
Externí odkaz:
https://doaj.org/article/dcffca0ec8bf450998939187bae4d56e
Autor:
Massimo Conese, Ottavio Napolitano, Onofrio Laselva, Sante Di Gioia, Luigi Nappi, Luigia Trabace, Maria Matteo
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 4, p 3612 (2023)
The pathomechanisms of preeclampsia (PE), a complication of late pregnancy characterized by hypertension and proteinuria, and due to improper placentation, are not well known. Mesenchymal stem cells derived from the amniotic membrane (AMSCs) may play
Externí odkaz:
https://doaj.org/article/de489b9dc74a40b3ad7c5e5682d5d81e