Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Onno Schaap"'
Autor:
Giovanni Esposito, Melissa Vos, Sven Vilain, Jef Swerts, Jorge De Sousa Valadas, Stefanie Van Meensel, Onno Schaap, Patrik Verstreken
Publikováno v:
PLoS Genetics, Vol 9, Iss 4, p e1003478 (2013)
The PTEN-induced kinase 1 (PINK1) is a mitochondrial kinase, and pink1 mutations cause early onset Parkinson's disease (PD) in humans. Loss of pink1 in Drosophila leads to defects in mitochondrial function, and genetic data suggest that another PD-re
Externí odkaz:
https://doaj.org/article/564fb14719d54e73b92ed880fbc2a0f8
Autor:
Sven Vilain, Giovanni Esposito, Dominik Haddad, Onno Schaap, Mariya P Dobreva, Melissa Vos, Stefanie Van Meensel, Vanessa A Morais, Bart De Strooper, Patrik Verstreken
Publikováno v:
PLoS Genetics, Vol 8, Iss 1, p e1002456 (2012)
Pink1 is a mitochondrial kinase involved in Parkinson's disease, and loss of Pink1 function affects mitochondrial morphology via a pathway involving Parkin and components of the mitochondrial remodeling machinery. Pink1 loss also affects the enzymati
Externí odkaz:
https://doaj.org/article/fab4c4340126431da8700027a5a93c2d
Autor:
Yangan Chen, Johan Memelink, Peter G. L. Klinkhamer, Onno Schaap, Patrick P.J. Mulder, Klaas Vrieling
Publikováno v:
Journal of Systematics and Evolution 60 (2022) 2
Journal of Systematics and Evolution, 60(2), 361-376
Journal of Systematics and Evolution, 60(2), 361-376
Plants produce many secondary metabolites showing considerable inter- and intraspecific diversity of concentration and composition as a strategy to cope with environmental stresses. The evolution of plant defenses against herbivores and pathogens can
Autor:
Ronny Decorte, Kate van Duijn, Andreas Wollstein, Oscar Lao, Lutz Roewer, Silke Brauer, Miriam Goedbloed, Onno Schaap, Damian Labuda, Manohar R. Furtado, Rafał Płoski, Ying Choi, Lotte Henke, Kaye N. Ballantyne, Rixun Fang, Nicole von Wurmb-Schwark, Jürgen Henke, Peter de Knijff, Hélène Vézina, Manfred Kayser, Micaela Poetsch, Hans Knoblauch, Rüdiger Lessig, Tadeusz Dobosz, Mark Vermeulen
Publikováno v:
American Journal of Human Genetics, 87(3), 341-353
American Journal of Human Genetics, 87(3), 341-353. Cell Press
American Journal of Human Genetics, 87(3), 341-353. Cell Press
Nonrecombining Y-chromosomal microsatellites (Y-STRs) are widely used to infer population histories, discover genealogical relationships, and identify males for criminal justice purposes. Although a key requirement for their application is reliable m
Autor:
Ben N G Giepmans, Harry van Goor, Wilfred F. A. den Dunnen, Lucas Kuijpers, Madina Baratashvili, Pascale F. Dijkers, Onno Schaap, Milos R. Filipovic, Henri G. D. Leuvenink, Sippie Huitema, Ody C. M. Sibon, Nicola A. Grzeschik, Jan Lj. Miljkovic, Jeroen Kuipers, Harm H. Kampinga, Pauline M. Snijder, Csaba Szabó, Eelke M. Bos, Aleksandra Mitrović
Publikováno v:
Molecular medicine, 21, 758-768. FEINSTEIN INST MED RES
Molecular Medicine
Molecular Medicine
Spinocerebellar ataxia type 3 (SCA3) is a polyglutamine (polyQ) disorder caused by a CAG repeat expansion in the ataxin-3 (ATXN3) gene resulting in toxic protein aggregation. Inflammation and oxidative stress are considered secondary factors contribu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0395df79e95a105e464c2a87429e5857
https://research.rug.nl/en/publications/9f8c4a0c-3dc8-45fb-b049-60a92496155f
https://research.rug.nl/en/publications/9f8c4a0c-3dc8-45fb-b049-60a92496155f
Autor:
Vanessa A. Morais, Patrik Verstreken, Onno Schaap, Sven Vilain, Melissa Vos, Bart De Strooper, Giovanni Esposito, Stefanie Van Meensel, Dominik Haddad, Janaka N. Edirisinghe, Jan R. Slabbaert, R. Meganathan
Keeping Mitochondria in the Pink Pink1 is a mitochondrial kinase, and loss of Pink1 function in flies and mice results in the accumulation of inefficient mitochondria. In a screen for modifiers of the Parkinson-associated gene, pink1 , Vos et al. (p.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7fa31166c3a4bb8dc9c15640ee5c89f
http://www.sciencemag.org/cgi/pmidlookup?view=long&pmid=22582012
http://www.sciencemag.org/cgi/pmidlookup?view=long&pmid=22582012
Autor:
Melissa Vos, Mariya P. Dobreva, Sven Vilain, Patrik Verstreken, Vanessa A. Morais, Stefanie Van Meensel, Onno Schaap, Dominik Haddad, Bart De Strooper, Giovanni Esposito
Publikováno v:
PLoS Genetics
PLoS Genetics, Vol 8, Iss 1, p e1002456 (2012)
PLoS Genetics, Vol 8, Iss 1, p e1002456 (2012)
Pink1 is a mitochondrial kinase involved in Parkinson's disease, and loss of Pink1 function affects mitochondrial morphology via a pathway involving Parkin and components of the mitochondrial remodeling machinery. Pink1 loss also affects the enzymati
Autor:
Ellen A. A. Nollen, Cristina Colombelli, Roald A. Lambrechts, Nicola A. Grzeschik, Ajda Podgoršek, Hrvoje Petković, Balaji Srinivasan, Ody C. M. Sibon, Bart Kanon, Valeria Tiranti, Susan J. Hayflick, Marianne van der Zwaag, Dirk-Jan Reijngoud, Onno Schaap, Gregor Kosec, Madina Baratashvili
Publikováno v:
Nature Chemical Biology, 11(10), 784-792.e3. Nature Publishing Group
The metabolic cofactor coenzyme A (CoA) gained renewed attention because of its roles in neurodegeneration, protein acetylation, autophagy and signal transduction. The long-standing dogma is that eukaryotic cells obtain CoA exclusively via the uptake
Autor:
Peter Heutink, Giuseppe Meco, Ben A. Oostra, Marijke Joosse, Ferdinando Squitieri, Patrizia Rizzu, Onno Schaap, Pablo Ibanez, Guido J. Breedveld, Vincenzo Bonifati, Marieke C. J. Dekker, Elmar Krieger, Marijke J. van Baren, Nicola Vanacore, Cornelia M. van Duijn, Alexis Brice, Jeroen W.F. van Dongen, John C. van Swieten
Publikováno v:
Science, 299, 256-259. American Association for the Advancement of Science
Science, 299, pp. 256-9
Science, 299, 256-9
Science, 299, pp. 256-9
Science, 299, 256-9
The DJ-1 gene encodes a ubiquitous, highly conserved protein. Here, we show that DJ-1 mutations are associated with PARK7, a monogenic form of human parkinsonism. The function of the DJ-1 protein remains unknown, but evidence suggests its involvement
Autor:
Sven Vilain, Jef Swerts, Stefanie Van Meensel, Patrik Verstreken, Melissa Vos, Onno Schaap, Jorge S. Valadas, Giovanni Esposito
Publikováno v:
PLoS Genetics
PLoS Genetics, Vol 9, Iss 4, p e1003478 (2013)
PLoS Genetics, Vol 9, Iss 4, p e1003478 (2013)
The PTEN-induced kinase 1 (PINK1) is a mitochondrial kinase, and pink1 mutations cause early onset Parkinson's disease (PD) in humans. Loss of pink1 in Drosophila leads to defects in mitochondrial function, and genetic data suggest that another PD-re