Zobrazeno 1 - 10
of 238
pro vyhledávání: '"Onno C. Meijer"'
Autor:
Sam Geuens, Jeroen Van Dessel, Rosanne Govaarts, Nadine A. Ikelaar, Onno C. Meijer, Hermien E. Kan, Erik H. Niks, Nathalie Goemans, Jurgen Lemiere, Nathalie Doorenweerd, Liesbeth De Waele
Publikováno v:
Annals of Clinical and Translational Neurology, Vol 10, Iss 12, Pp 2324-2333 (2023)
Abstract Objective Duchenne muscular dystrophy (DMD) is a neuromuscular disorder in which many patients also have neurobehavioral problems. Corticosteroids, the primary pharmacological treatment for DMD, have been shown to affect brain morphology in
Externí odkaz:
https://doaj.org/article/add3ba9314e94a10b739bcd5d963f0ee
Autor:
Mahshid Gazorpak, Karina M. Hugentobler, Dominique Paul, Pierre-Luc Germain, Miriam Kretschmer, Iryna Ivanova, Selina Frei, Kei Mathis, Remo Rudolf, Sergio Mompart Barrenechea, Vincent Fischer, Xiaohan Xue, Aleksandra L. Ptaszek, Julian Holzinger, Mattia Privitera, Andreas Hierlemann, Onno C. Meijer, Robert Konrat, Erick M. Carreira, Johannes Bohacek, Katharina Gapp
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-23 (2023)
Abstract Counteracting the overactivation of glucocorticoid receptors (GR) is an important therapeutic goal in stress-related psychiatry and beyond. The only clinically approved GR antagonist lacks selectivity and induces unwanted side effects. To co
Externí odkaz:
https://doaj.org/article/a28a8f76999f4d2694653264846e8de2
Autor:
Agnes van Minnen, Lizelotte Vos, Pierre M. Bet, Ad de Jongh, Felix Linsen, Hein J. F. van Marle, Onno C. Meijer, Willem M. Otte, Marije Russcher, Christiaan H. Vinkers
Publikováno v:
Case Reports in Psychiatry, Vol 2024 (2024)
Despite the availability of various treatment approaches for patients with posttraumatic stress disorder (PTSD), some patients do not respond to these therapies, and novel treatment approaches are needed. This study investigated the efficacy of mifep
Externí odkaz:
https://doaj.org/article/8c8392000c1d4da7902ea8fa4857941e
Publikováno v:
Frontiers in Endocrinology, Vol 14 (2024)
Glucocorticoids are key executors of the physiological response to stress. Previous studies in mice showed that the androgen receptor (AR) influenced the transcriptional outcome of glucocorticoid treatment in white and brown adipocytes and in the liv
Externí odkaz:
https://doaj.org/article/18704b8aa434448193c906978a1aa8a7
Autor:
Philippe C. Habets, Konstantinos Kalafatakis, Oleh Dzyubachyk, Steven J.A. van der Werff, Arlin Keo, Jamini Thakrar, Ahmed Mahfouz, Alberto M. Pereira, Georgina M. Russell, Stafford L. Lightman, Onno C. Meijer
Publikováno v:
Neurobiology of Stress, Vol 22, Iss , Pp 100514- (2023)
The characteristic endogenous circadian rhythm of plasma glucocorticoid concentrations is made up from an underlying ultradian pulsatile secretory pattern. Recent evidence has indicated that this ultradian cortisol pulsatility is crucial for normal e
Externí odkaz:
https://doaj.org/article/9eed16f9152f48aa90b190994bf42f39
Autor:
Lisa L. Koorneef, Merel van der Meulen, Sander Kooijman, Elena Sánchez-López, Jari F. Scheerstra, Maaike C. Voorhoeve, Ajith N. Nadamuni Ramesh, Patrick C. N. Rensen, Martin Giera, Jan Kroon, Onno C. Meijer
Publikováno v:
Frontiers in Endocrinology, Vol 13 (2022)
Synthetic glucocorticoids are clinically used to treat auto-immune and inflammatory disease. Despite the high efficacy, glucocorticoid treatments causes side effects such as obesity and insulin resistance in many patients. Via their pharmacological t
Externí odkaz:
https://doaj.org/article/5db24c94244c410bb742c1672b9f6255
Autor:
Laura Van Moortel, Jonathan Thommis, Brecht Maertens, An Staes, Dorien Clarisse, Delphine De Sutter, Claude Libert, Onno C. Meijer, Sven Eyckerman, Kris Gevaert, Karolien De Bosscher
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 152, Iss , Pp 113218- (2022)
Exogenous glucocorticoids are widely used in the clinic for the treatment of inflammatory disorders and auto-immune diseases. Unfortunately, their use is hampered by many side effects and therapy resistance. Efforts to find more selective glucocortic
Externí odkaz:
https://doaj.org/article/3ea8fec4a38b405ca162e321ff493bb9
Autor:
Sheng Li, Milena Schönke, Jacobus C. Buurstede, Tijmen J.A. Moll, Max Gentenaar, Maaike Schilperoort, Jenny A. Visser, Kasiphak Kaikaew, Davy van de Vijver, Tooba Abbassi-Daloii, Vered Raz, Annemieke Aartsma-Rus, Maaike van Putten, Onno C. Meijer, Jan Kroon
Publikováno v:
Frontiers in Endocrinology, Vol 13 (2022)
Muscle atrophy is common in patients with increased glucocorticoid exposure. Glucocorticoid effects are often sex-specific, and while different glucocorticoid responses between male and female subjects are reported, it is unclear why this is. In this
Externí odkaz:
https://doaj.org/article/946e91433eb44975b8e7480eca6ca3bc
Publikováno v:
Neurobiology of Stress, Vol 18, Iss , Pp 100455- (2022)
‘You can't roll the clock back and reverse the effects of experiences' Bruce McEwen used to say when explaining how allostasis labels the adaptive process. Here we will for once roll the clock back to the times that the science of the glucocorticoi
Externí odkaz:
https://doaj.org/article/54d5b0edf50c4e53b7ec8bfbaace90fa
Autor:
Joost Brinks, Femke M. van Haalen, Thomas J. van Rijssen, Nienke R. Biermasz, Onno C. Meijer, Alberto M. Pereira, Camiel J. F. Boon, Elon H. C. van Dijk
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
Abstract Multiple case series have provided evidence for a relatively high incidence of central serous chorioretinopathy (CSC) in patients with active Cushing’s syndrome (CS). We describe the ophthalmological status in detail of consecutive patient
Externí odkaz:
https://doaj.org/article/21d8ef25b75241b18ecca2bc674ce6ba