Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Onno B. Bleijerveld"'
Autor:
Zeliha Yalçin, Shiu Yeung Lam, Marieke H. Peuscher, Jaco van der Torre, Sha Zhu, Prasanna V. Iyengar, Daniel Salas-Lloret, Inge de Krijger, Nathalie Moatti, Ruben van der Lugt, Mattia Falcone, Aurora Cerutti, Onno B. Bleijerveld, Liesbeth Hoekman, Román González-Prieto, Jacqueline J. L. Jacobs
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Maintenance of genome integrity requires tight control of DNA damage response (DDR) signalling and repair, with phosphorylation and ubiquitination representing key elements. How these events are coordinated to achieve productive DNA repair r
Externí odkaz:
https://doaj.org/article/5904fb9cf15e4ea0bcf5f618e256368f
Autor:
Changpei Gan, Jing Wang, Yaogeng Wang, Alejandra Martínez-Chávez, Michel Hillebrand, Niels de Vries, Joke Beukers, Maria C. Lebre, Els Wagenaar, Hilde Rosing, Sjoerd Klarenbeek, Onno B. Bleijerveld, Ji-Ying Song, Maarten Altelaar, Jos H. Beijnen, Alfred H. Schinkel
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 164, Iss , Pp 114956- (2023)
Mammalian carboxylesterase 1 enzymes can hydrolyze many xenobiotic chemicals and endogenous lipids. We here identified and characterized a mouse strain (FVB/NKI) in which three of the eight Ces1 genes were spontaneously deleted, removing Ces1c and Ce
Externí odkaz:
https://doaj.org/article/6feb859d901d4d4c97531a2a7f1a6338
Autor:
Georgi Apriamashvili, David W. Vredevoogd, Oscar Krijgsman, Onno B. Bleijerveld, Maarten A. Ligtenberg, Beaunelle de Bruijn, Julia Boshuizen, Joleen J. H. Traets, Daniela D’Empaire Altimari, Alex van Vliet, Chun-Pu Lin, Nils L. Visser, James D. Londino, Rebekah Sanchez-Hodge, Leah E. Oswalt, Selin Altinok, Jonathan C. Schisler, Maarten Altelaar, Daniel S. Peeper
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
The IFNγ response pathway is associated with response to immunotherapy in cancer. Here the authors show that high levels of the IFNγ-receptor (IFNγ-R1) affect the outcome of immunotherapy in a context-dependent fashion and identify the E3 ubiquiti
Externí odkaz:
https://doaj.org/article/f0bd442465bb48f98bd8089ae3c35166
Autor:
Li Li, Alejandro P. Ugalde, Colinda L. G. J. Scheele, Sebastian M. Dieter, Remco Nagel, Jin Ma, Abhijeet Pataskar, Gozde Korkmaz, Ran Elkon, Miao-Ping Chien, Li You, Pin-Rui Su, Onno B. Bleijerveld, Maarten Altelaar, Lyubomir Momchev, Zohar Manber, Ruiqi Han, Pieter C. van Breugel, Rui Lopes, Peter ten Dijke, Jacco van Rheenen, Reuven Agami
Publikováno v:
Genome Biology, Vol 22, Iss 1, Pp 1-28 (2021)
Abstract Background Frequent activation of the co-transcriptional factor YAP is observed in a large number of solid tumors. Activated YAP associates with enhancer loci via TEAD4-DNA-binding protein and stimulates cancer aggressiveness. Although thous
Externí odkaz:
https://doaj.org/article/c775eb768cb945179e71e99f571ae872
Autor:
Kristel Kemper, Oscar Krijgsman, Xiangjun Kong, Paulien Cornelissen-Steijger, Aida Shahrabi, Fleur Weeber, Daphne L. van der Velden, Onno B. Bleijerveld, Thomas Kuilman, Roel J.C. Kluin, Chong Sun, Emile E. Voest, Young Seok Ju, Ton N.M. Schumacher, A.F. Maarten Altelaar, Ultan McDermott, David J. Adams, Christian U. Blank, John B. Haanen, Daniel S. Peeper
Publikováno v:
Cell Reports, Vol 16, Iss 1, Pp 263-277 (2016)
The therapeutic landscape of melanoma is improving rapidly. Targeted inhibitors show promising results, but drug resistance often limits durable clinical responses. There is a need for in vivo systems that allow for mechanistic drug resistance studie
Externí odkaz:
https://doaj.org/article/b4e20b0f1b48444f832fabb5c11f6dd8
Autor:
Marianne Boes, Stefan Nierkens, Thijn R. Brummelkamp, Jaap Jan Boelens, Maarten Altelaar, Onno B. Bleijerveld, Elmer Stickel, Rianne Haarsma, Joppe Nieuwenhuis, Lotte Spel
List of used antibodies, plasmids, gRNA sequences and datasets. Figures showing expression data, gene correlations, cell line clonality, screen replicates, and protein expression in neuroblastoma cells.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c2b3bbf4485a26726704e9603fe9496
https://doi.org/10.1158/0008-5472.22418492.v1
https://doi.org/10.1158/0008-5472.22418492.v1
Autor:
Marianne Boes, Stefan Nierkens, Thijn R. Brummelkamp, Jaap Jan Boelens, Maarten Altelaar, Onno B. Bleijerveld, Elmer Stickel, Rianne Haarsma, Joppe Nieuwenhuis, Lotte Spel
Basemean and fold change scores per indivudual gRNA used in the CRISPR screen resulting in a significant TRUE of FALSE hit in the screen.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c174cda1170abebb8180b5277a2c1d9
https://doi.org/10.1158/0008-5472.22418489.v1
https://doi.org/10.1158/0008-5472.22418489.v1
Autor:
Marianne Boes, Stefan Nierkens, Thijn R. Brummelkamp, Jaap Jan Boelens, Maarten Altelaar, Onno B. Bleijerveld, Elmer Stickel, Rianne Haarsma, Joppe Nieuwenhuis, Lotte Spel
Neuroblastoma is the second most common tumor in children. The cause of neuroblastoma is thought to lie in aberrant development of embryonic neural crest cells and is accompanied by low MHC-1 expression and suppression of the NF-κB transcription fac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::baecfbbf02b4677cbf52b38a87fdb709
https://doi.org/10.1158/0008-5472.c.6510143
https://doi.org/10.1158/0008-5472.c.6510143
Autor:
Zeliha Yalçin, Daniëlle Koot, Karel Bezstarosti, Daniel Salas-Lloret, Onno B. Bleijerveld, Vera Boersma, Mattia Falcone, Román González-Prieto, Maarten Altelaar, Jeroen A.A. Demmers, Jacqueline J.L. Jacobs
Publikováno v:
Molecular & Cellular Proteomics. 22:100548
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::346623f55afe523110eed7351629a073
https://doi.org/10.1016/j.mcpro.2023.100548
https://doi.org/10.1016/j.mcpro.2023.100548
Autor:
Alba Zuidema, Paul Atherton, Maaike Kreft, Liesbeth Hoekman, Onno B. Bleijerveld, Nagarjuna Nagaraj, Nanpeng Chen, Reinhard Fässler, Arnoud Sonnenberg
Publikováno v:
Journal of Cell Biology. 221
Integrins mediate cell adhesion by connecting the extracellular matrix to the intracellular cytoskeleton and orchestrate signal transduction in response to chemical and mechanical stimuli by interacting with many cytoplasmic proteins. We used BioID t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7dd8e980d781c29784c14919fed0372
https://doi.org/10.1083/jcb.202108027
https://doi.org/10.1083/jcb.202108027