Time to diagnosis of tuberculosis is greater in older patients: a retrospective cohort review

Autor: Aula Abbara, Simon M. Collin, Onn M. Kon, Kevin Buell, Adam Sullivan, Jessica Barrett, Tumena Corrah, Alastair McGregor, Trevor Hansel, Laurence John, Robert N. Davidson

Publikováno v: ERJ Open Research, Vol 5, Iss 4 (2019)

Introduction Age-related immunosenescence influences the presentation of tuberculosis (TB) in older patients. Here, we explore the clinical and radiological presentation of TB in the elderly and the factors associated with time to treatment for TB. M

Externí odkaz: https://doaj.org/article/70f2cc050c5f428cbd68d5ee8ea158fb

Proteomic Analysis of Kveim Reagent Identifies Targets of Cellular Immunity in Sarcoidosis.

Autor: Christian Eberhardt, Muhunthan Thillai, Robert Parker, Nazneen Siddiqui, Lee Potiphar, Rob Goldin, John F Timms, Athol U Wells, Onn M Kon, Melissa Wickremasinghe, Donald Mitchell, Mark E Weeks, Ajit Lalvani

Publikováno v: PLoS ONE, Vol 12, Iss 1, p e0170285 (2017)

Kveim-reagent (Kv) skin testing was a historical method of diagnosing sarcoidosis. Intradermal injection of treated sarcoidosis spleen tissue resulted in a granuloma response at injection site by 4-6 weeks. Previous work indicates proteins as the pos

Externí odkaz: https://doaj.org/article/b6af6f3e18bf4054b48ff767b45864dd

Correction: The Role of IL-15 Deficiency in the Pathogenesis of Virus-Induced Asthma Exacerbations.

Autor: Vasile Laza-Stanca, Simon D. Message, Michael R. Edwards, Hayley L. Parker, Mihnea T. Zdrenghea, Tatiana Kebadze, Onn M. Kon, Patrick Mallia, Luminita A. Stanciu, Sebastian L. Johnston

Publikováno v: PLoS Pathogens, Vol 8, Iss 4 (2012)

Externí odkaz: https://doaj.org/article/81cd5145d6104e408179d24af386d2b4

The role of IL-15 deficiency in the pathogenesis of virus-induced asthma exacerbations.

Autor: Vasile Laza-Stanca, Simon D Message, Michael R Edwards, Hayley L Parker, Mihnea T Zdrenghea, Tatiana Kebadze, Onn M Kon, Patrick Mallia, Luminita A Stanciu, Sebastian L Johnston

Publikováno v: PLoS Pathogens, Vol 7, Iss 7, p e1002114 (2011)

Rhinovirus infections are the major cause of asthma exacerbations. We hypothesised that IL-15, a cytokine implicated in innate and acquired antiviral immunity, may be deficient in asthma and important in the pathogenesis of asthma exacerbations. We i

Externí odkaz: https://doaj.org/article/e9e8861e165547c4b6caaaf773a7fc0f

Multiorgan MRI findings after hospitalisation with COVID-19 in the UK (C-MORE): a prospective, multicentre, observational cohort study

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Choudhury, Gourab, Diar Bakerly, Nawar, Easom, Nicholas, Echevarria, Carlos, Marks, Michael, Hurst, John R, Jones, Mark G, Wootton, Daniel G, Chalder, Trudie, Davies, Melanie J, De Soyza, Anthony, Geddes, John R, Greenhalf, William, Howard, Luke S, Jacob, Joseph, Man, William D-C, Openshaw, Peter J M, Porter, Joanna C, Rowland, Matthew J, Scott, Janet T, Singh, Sally J, Thomas, David C, Toshner, Mark, Lewis, Keir E, Heaney, Liam G, Harrison, Ewen M, Kerr, Steven, Docherty, Annemarie B, Lone, Nazir I, Quint, Jennifer, Sheikh, Aziz, Zheng, Bang, Jenkins, R Gisli, Cox, Eleanor, Francis, Susan, Halling-Brown, Mark, Chalmers, James D, Greenwood, John P, Plein, Sven, Hughes, Paul J C, Thompson, A A Roger, Rowland-Jones, Sarah L, Wild, James M, Kelly, Matthew, Treibel, Thomas A, Bandula, Steven, Aul, Raminder, Miller, Karla, Jezzard, Peter, Smith, Stephen, Nichols, Thomas E, McCann, Gerry P, Evans, Rachael A, Wain, Louise V, Brightling, Christopher E, Neubauer, Stefan, Baillie, J K, Shaw, Alison, Hairsine, Brigid, Kurasz, Claire, Henson, Helen, Armstrong, Lisa, Shenton, Liz, Dobson, H, Dell, Amanda, Lucey, Alice, Price, Andrea, Storrie, Andrew, Pennington, Chris, Price, Claire, Mallison, Georgia, Willis, Gemma, Nassa, Heeah, Haworth, Jill, Hoare, Michaela, Hawkings, Nancy, Fairbairn, Sara, Young, Susan, Walker, S, Jarrold, I, Sanderson, Amy, David, C, Chong-James, K, Zongo, O, James, W Y, Martineau, A, King, Bernie, Armour, C, McAulay, D, Major, E, McGinness, Jade, McGarvey, L, Magee, N, Stone, Roisin, Drain, S, Craig, T, Bolger, A, Haggar, Ahmed, Lloyd, Arwel, Subbe, Christian, Menzies, Daniel, Southern, David, McIvor, Emma, Roberts, K, Manley, R, Whitehead, Victoria, Saxon, W, Bularga, A, Mills, N L, El-Taweel, Hosni, Dawson, Joy, Robinson, Leanne, Saralaya, Dinesh, Regan, Karen, Storton, Kim, Brear, Lucy, Amoils, S, Bermperi, Areti, Elmer, Anne, Ribeiro, Carla, Cruz, Isabel, Taylor, Jessica, Worsley, J, Dempsey, K, Watson, L, Jose, Sherly, Marciniak, S, Parkes, M, 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Publikováno v: In The Lancet Respiratory Medicine November 2023 11(11):1003-1019