Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Onn Brandman"'
Publikováno v:
eLife, Vol 12 (2024)
While inhomogeneous diffusivity has been identified as a ubiquitous feature of the cellular interior, its implications for particle mobility and concentration at different length scales remain largely unexplored. In this work, we use agent-based simu
Externí odkaz:
https://doaj.org/article/02c3fd4033934f8f8ea9c71ed703f8ec
Autor:
Ji Geng, Shuangxi Li, Yu Li, Zhihao Wu, Sunil Bhurtel, Suman Rimal, Danish Khan, Rani Ohja, Onn Brandman, Bingwei Lu
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Translational control exerts immediate effect on the composition, abundance, and integrity of the proteome. Ribosome-associated quality control (RQC) handles ribosomes stalled at the elongation and termination steps of translation, with ZNF5
Externí odkaz:
https://doaj.org/article/992df18d0d6e406991eea85200ad04af
Autor:
Brian D Alford, Eduardo Tassoni-Tsuchida, Danish Khan, Jeremy J Work, Gregory Valiant, Onn Brandman
Publikováno v:
eLife, Vol 10 (2021)
Understanding cellular stress response pathways is challenging because of the complexity of regulatory mechanisms and response dynamics, which can vary with both time and the type of stress. We developed a reverse genetic method called ReporterSeq to
Externí odkaz:
https://doaj.org/article/4c2c2428d60a4078a4902a653724aa68
Publikováno v:
PLoS ONE, Vol 15, Iss 1, p e0227841 (2020)
The Ribosome-associated Quality Control (RQC) pathway co-translationally marks incomplete polypeptides from stalled translation with two signals that trigger their proteasome-mediated degradation. The E3 ligase Ltn1 adds ubiquitin and Rqc2 directs th
Externí odkaz:
https://doaj.org/article/9d8bcab1a7d44671a4fd54de79645487
Publikováno v:
PLoS ONE, Vol 7, Iss 11, p e48275 (2012)
A major limitation to yeast aging study has been the inability to track mother cells and observe molecular markers during the aging process. The traditional lifespan assay relies on manual micro-manipulation to remove daughter cells from the mother,
Externí odkaz:
https://doaj.org/article/027d7300717d4a4e95dfd0bbb5f9445c
While inhomogeneous viscosity has been identified as a ubiquitous feature of the cellular interior, its implications for particle mobility and concentration at different length scales remain largely unexplored. In this work, we use agent-based simula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9a5ecf0b0ddb80eebb3b04cda8e13b1c
https://doi.org/10.1101/2022.08.30.505927
https://doi.org/10.1101/2022.08.30.505927
Autor:
H. Broder Schmidt, Zane A. Jaafar, B. Erik Wulff, Jason J. Rodencal, Kibeom Hong, Mohammad O. Aziz-Zanjani, Peter K. Jackson, Manuel D. Leonetti, Scott J. Dixon, Rajat Rohatgi, Onn Brandman
Publikováno v:
Cell reports, vol 41, iss 6
Platinum (Pt) compounds such as oxaliplatin are among the most commonly prescribed anti-cancer drugs. Despite their considerable clinical impact, the molecular basis of platinum cytotoxicity and cancer specificity remain unclear. Here we show that ox
The ubiquitin-proteasome system (UPS) is critical for cellular and organismal health. To uncover mechanisms regulating the UPS in normal and stress conditions, we systematically probed the genome of the eukaryotic model system Saccharomyces cerevisia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d56ef9021db667e46a491ff14a3d7113
https://doi.org/10.1101/2021.08.19.456712
https://doi.org/10.1101/2021.08.19.456712
Autor:
Eduardo Tassoni-Tsuchida, Danish Khan, Onn Brandman, Gregory Valiant, Jeremy J. Work, Brian D. Alford
Publikováno v:
eLife, Vol 10 (2021)
eLife
eLife
Understanding cellular stress response pathways is challenging because of the complexity of regulatory mechanisms and response dynamics, which can vary with both time and the type of stress. We developed a reverse genetic method called ReporterSeq to