The non-coding variant rs1800734 enhances DCLK3 expression through long-range interaction and promotes colorectal cancer progression

Autor: Ning Qing Liu, Menno ter Huurne, Luan N. Nguyen, Tianran Peng, Shuang-Yin Wang, James B. Studd, Onkar Joshi, Halit Ongen, Jesper B Bramsen, Jian Yan, Claus L. Andersen, Jussi Taipale, Emmanouil T. Dermitzakis, Richard S. Houlston, Nina C. Hubner, Hendrik G. Stunnenberg

Publikováno v: Nature Communications, Vol 8, Iss 1, Pp 1-10 (2017)

Functional characterisation of non-coding risk variants for colorectal cancer is missing. Here the authors conduct a large-scale proteome-wide analysis of disease associated SNPs to characterize allele-specific transcription factor binding landscape

Externí odkaz: https://doaj.org/article/8044c297681a490eaa5ba7372d960195

Optimization Study of Tilt Angle for Single Slope Solar Still

Autor: Onkar Joshi

Publikováno v: International Journal for Research in Applied Science and Engineering Technology. 9:161-167

Water is essential to life. The origin and continuation of mankind is based on water. The supply of drinking water is an important problem for the developing countries. The wooden box has a thickness of 8mm. It consists of a top cover of transparent

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6f29f48763decdd7e0a9a91866ccaf72
https://doi.org/10.22214/ijraset.2021.37283

A unique bipartite Polycomb signature regulates stimulus-response transcription during development

Autor: Charlotte Soneson, Michael B. Stadler, Guillermina López-Bendito, Onkar Joshi, Nicola A. Maiorano, Sebastien Ducret, Sandra Kessler, Henrik Gezelius, Taro Kitazawa, Filippo M. Rijli, Hubertus Kohler, Panagiotis Papasaikas, Dania Machlab

Publikováno v: Nature Genetics
Nature genetics
Digital.CSIC. Repositorio Institucional del CSIC
instname

Rapid cellular responses to environmental stimuli are fundamental for development and maturation. Immediate early genes can be transcriptionally induced within minutes in response to a variety of signals. How their induction levels are regulated and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8451090d042b02c5439ab87fcee3cca7

Epigenetic modulation of a hardwired 3D chromatin landscape in two naive states of pluripotency

Autor: Yaser, Atlasi, Wout, Megchelenbrink, Tianran, Peng, Ehsan, Habibi, Onkar, Joshi, Shuang-Yin, Wang, Cheng, Wang, Colin, Logie, Ina, Poser, Hendrik, Marks, Hendrik G, Stunnenberg

Publikováno v: Nature cell biology. 21(5)

The mechanisms underlying enhancer activation and the extent to which enhancer-promoter rewiring contributes to spatiotemporal gene expression are not well understood. Using integrative and time-resolved analyses we show that the extensive transcript

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f72d7dc3ccb63682d707f17b6145dcb5
https://pubmed.ncbi.nlm.nih.gov/31097792

The non-coding variant rs1800734 enhances DCLK3 expression through long-range interaction and promotes colorectal cancer progression

Autor: Hendrik G. Stunnenberg, Nina C. Hubner, Richard S. Houlston, Halit Ongen, James B. Studd, Shuang-Yin Wang, Luan Nguyen, Claus L. Andersen, Onkar Joshi, Jesper B. Bramsen, Jian Yan, Jussi Taipale, Tianran Peng, Menno ter Huurne, Emmanouil T. Dermitzakis, Ning Qing Liu

Publikováno v: Liu, N Q, Ter Huurne, M, Nguyen, L N, Peng, T, Wang, S-Y, Studd, J B, Joshi, O, Ongen, H, Bramsen, J B, Yan, J, Andersen, C L, Taipale, J, Dermitzakis, E T, Houlston, R S, Hubner, N C & Stunnenberg, H G 2017, ' The non-coding variant rs1800734 enhances DCLK3 expression through long-range interaction and promotes colorectal cancer progression ', Nature Communications, vol. 8, pp. 14418 . https://doi.org/10.1038/ncomms14418
Nature Communications, 8, 1-10
Nature Communications
Nature Communications, Vol. 8 (2017) P. 14418
Nature Communications, 8, pp. 1-10
Nature Communications, Vol 8, Iss 1, Pp 1-10 (2017)

Genome-wide association studies have identified a great number of non-coding risk variants for colorectal cancer (CRC). To date, the majority of these variants have not been functionally studied. Identification of allele-specific transcription factor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7cd5dbc1a96e944a462eec1c6c39805
https://pure.au.dk/portal/da/publications/the-noncoding-variant-rs1800734-enhances-dclk3-expression-through-longrange-interaction-and-promotes-colorectal-cancer-progression(10bd73d7-545e-461b-bf4a-9f7d42d5c708).html