Molecular profiling of the artemisinin resistance Kelch 13 gene in Plasmodium falciparum from Nigeria.

Autor: Fehintola V Ajogbasile, Paul E Oluniyi, Adeyemi T Kayode, Kazeem O Akano, Benjamin B Adegboyega, Courage Philip, Nnenna Ogbulafor, Henrietta U Okafor, Stephen Oguche, Robinson D Wammanda, Olugbenga A Mokuolu, Onikepe A Folarin, Christian T Happi

Publikováno v: PLoS ONE, Vol 17, Iss 2, p e0264548 (2022)

Accurate assessment and monitoring of the Plasmodium falciparum Kelch 13 (pfk13) gene associated with artemisinin resistance is critical to understand the emergence and spread of drug-resistant parasites in malaria-endemic regions. In this study, we

Externí odkaz: https://doaj.org/article/1500dcecdaad471d81f90f5384f834e7

Lassa fever in post-conflict sierra leone.

Autor: Jeffrey G Shaffer, Donald S Grant, John S Schieffelin, Matt L Boisen, Augustine Goba, Jessica N Hartnett, Danielle C Levy, Rachael E Yenni, Lina M Moses, Mohammed Fullah, Mambo Momoh, Mbalu Fonnie, Richard Fonnie, Lansana Kanneh, Veronica J Koroma, Kandeh Kargbo, Darin Ottomassathien, Ivana J Muncy, Abigail B Jones, Megan M Illick, Peter C Kulakosky, Allyson M Haislip, Christopher M Bishop, Deborah H Elliot, Bethany L Brown, Hu Zhu, Kathryn M Hastie, Kristian G Andersen, Stephen K Gire, Shervin Tabrizi, Ridhi Tariyal, Mathew Stremlau, Alex Matschiner, Darryl B Sampey, Jennifer S Spence, Robert W Cross, Joan B Geisbert, Onikepe A Folarin, Christian T Happi, Kelly R Pitts, F Jon Geske, Thomas W Geisbert, Erica Ollmann Saphire, James E Robinson, Russell B Wilson, Pardis C Sabeti, Lee A Henderson, S Humarr Khan, Daniel G Bausch, Luis M Branco, Robert F Garry, Viral Hemorrhagic Fever Consortium

Publikováno v: PLoS Neglected Tropical Diseases, Vol 8, Iss 3, p e2748 (2014)

BACKGROUND:Lassa fever (LF), an often-fatal hemorrhagic disease caused by Lassa virus (LASV), is a major public health threat in West Africa. When the violent civil conflict in Sierra Leone (1991 to 2002) ended, an international consortium assisted i

Externí odkaz: https://doaj.org/article/55ad3c3b355949c08ef8d3693670c434

Polymorphisms in Plasmodium falciparum dihydropteroate synthetase and dihydrofolate reductase genes in Nigerian children with uncomplicated malaria using high-resolution melting technique

Autor: Adeyemi T. Kayode, Fehintola V. Ajogbasile, Kazeem Akano, Jessica N. Uwanibe, Paul E. Oluniyi, Philomena J. Eromon, Onikepe A. Folarin, Akintunde Sowunmi, Dyann F. Wirth, Christian T. Happi

Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)

Abstract In 2005, the Nigerian Federal Ministry of Health revised the treatment policy for uncomplicated malaria with the introduction of artemisinin-based combination therapies (ACTs). This policy change discouraged the use of Sulphadoxine-pyrimetha

Externí odkaz: https://doaj.org/article/7ecd3ef5a9d34f1f890f91a36e6c1caa

Atypical serologic profiles of hepatitis B virus infection across clinical cohorts of patients in Southwestern Nigeria

Autor: Oluwadamilola Gideon Osasona, Tosin Oguntoye, Philomena Eromon, Lukman Abdulkareem, Abiola Opeyemi Arowosaye, Olumuyiwa Elijah Ariyo, Uwem Etop George, Musa Yusuf, Olubusuyi Moses Adewumi, Christian Happi, Onikepe Abiola Folarin

Publikováno v: Journal of Immunoassay and Immunochemistry. 44:176-191

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::74bc022bc64f1693d6bc25bd57adddc8
https://doi.org/10.1080/15321819.2023.2168556

The Origins and Future of Sentinel: An Early-Warning System for Pandemic Preemption and Response

Autor: Yolanda Botti-Lodovico, Parvathy Nair, Dolo Nosamiefan, Matthew Stremlau, Stephen Schaffner, Sebastian V. Agignoae, John Oke Aiyepada, Fehintola V. Ajogbasile, George O. Akpede, Foday Alhasan, Kristian G. Andersen, Danny A. Asogun, Oladele Oluwafemi Ayodeji, Aida S. Badiane, Kayla Barnes, Matthew R. Bauer, Antoinette Bell-Kareem, Muoebonam Ekene Benard, Ebo Ohomoime Benevolence, Osiemi Blessing, Chloe K. Boehm, Matthew L. Boisen, Nell G. Bond, Luis M. Branco, Michael J. Butts, Amber Carter, Andres Colubri, Awa B. Deme, Katherine C. DeRuff, Younousse Diédhiou, Akhilomen Patience Edamhande, Siham Elhamoumi, Emily J. Engel, Philomena Eromon, Mosoka Fallah, Onikepe A. Folarin, Ben Fry, Robert Garry, Amy Gaye, Michael Gbakie, Sahr M. Gevao, Gabrielle Gionet, Adrianne Gladden-Young, Augustine Goba, Jules Francois Gomis, Anise N. Happi, Mary Houghton, Chikwe Ihekwuazu, Christopher Ojemiega Iruolagbe, Jonathan Jackson, Simbirie Jalloh, Jeremy Johnson, Lansana Kanneh, Adeyemi Kayode, Molly Kemball, Ojide Chiedozie Kingsley, Veronica Koroma, Dylan Kotliar, Samar Mehta, Hayden C. Metsky, Airende Michael, Marzieh Ezzaty Mirhashemi, Kayvon Modjarrad, Mambu Momoh, Cameron A. Myhrvold, Okonofua Grace Naregose, Tolla Ndiaye, Mouhamadou Ndiaye, Aliou Ndiaye, Erica Normandin, Ikponmwosa Odia, Judith Uche Oguzie, Sylvanus A. Okogbenin, Peter O. Okokhere, Johnson Okolie, Idowu B. Olawoye, Testimony J. Olumade, Paul E. Oluniyi, Omigie Omoregie, Daniel J. Park, Mariétou Faye Paye, Brittany Petros, Anthony A. Philippakis, Abechi Priscilla, Alan Ricks, Anne Rimoin, John Demby Sandi, John S. Schieffelin, Monica Schreiber, Mame Cheikh Seck, Sameed Siddiqui, Katherine Siddle, Allison R. Smither, Mouhamad Sy, Ngayo Sy, Christopher H. Tomkins-Tinch, Oyewale Tomori, Chinedu Ugwu, Jessica N. Uwanibe, Eghosasere Anthonia Uyigue, Dada Ireti Victoria, Anika Vinzé, Megan E. Vodzak, Nicole Welch, Haja Isatta Wurie, Daba Zoumarou, Donald S. Grant, Daouda Ndiaye, Bronwyn MacInnis, Pardis C. Sabeti, Christian Happi

Publikováno v: Viruses, Vol 13, Iss 8, p 1605 (2021)

While investigating a signal of adaptive evolution in humans at the gene LARGE, we encountered an intriguing finding by Dr. Stefan Kunz that the gene plays a critical role in Lassa virus binding and entry. This led us to pursue field work to test our

Externí odkaz: https://doaj.org/article/fdc2cdf7bd364441a6c4a021de0b3451