Neutrophil-Mediated Immunopathology and Matrix Metalloproteinases in Central Nervous System - Tuberculosis

Autor: Poh, XY, Loh, FK, Friedland, JS, Ong, CWM

Tuberculosis (TB) remains one of the leading infectious killers in the world, infecting approximately a quarter of the world's population with the causative organism Mycobacterium tuberculosis (M. tb). Central nervous system tuberculosis (CNS-TB) is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::45b3e9c4f9e6ca9b73cd094e438e04e3

Blood RNA signatures for 8-week sputum tuberculosis culture sterilisation: how close are we?

Autor: Thu WPP; Infectious Diseases Translational Research Programme, Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Loh FK; Infectious Diseases Translational Research Programme, Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Ong CWM; Infectious Diseases Translational Research Programme, Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore catherine.ong@nus.edu.sg.; Division of Infectious Diseases, Department of Medicine, National University Hospital, Singapore, Singapore.; Institute for Health Innovation and Technology (iHealthtech), National University of Singapore, Singapore, Singapore.

Publikováno v: The European respiratory journal [Eur Respir J] 2024 Nov 21; Vol. 64 (5). Date of Electronic Publication: 2024 Nov 21 (Print Publication: 2024).

Host-directed therapies: old and new approaches for the treatment of infections.

Autor: Goletti D; Translational Research Unit, Department of Epidemiology and Preclinical Research National Institute for Infectious Diseases L. Spallanzani-IRCCS, Roma, Italy. Electronic address: delia.goletti@inmi.it., Ong CWM; Infectious Diseases Translational Research Programme, Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore; Division of Infectious Diseases, Department of Medicine, National University Hospital, Singapore, Singapore; Institute for Health Innovation and Technology (iHealthtech), National University of Singapore, Singapore, Singapore., Friedland JS; Institute for Infection and Immunity, St George's, University of London, London, United Kingdom.

Publikováno v: International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases [Int J Infect Dis] 2024 Sep; Vol. 146, pp. 107130. Date of Electronic Publication: 2024 Jun 09.

Relative deficiency in interferon-γ-secreting CD4+ T cells is strongly associated with poorer COVID-19 vaccination responses in older adults.

Autor: Ho VWT; Division of Geriatric Medicine, Department of Medicine, National University Hospital, Singapore, Singapore.; Immunology Translational Research Program, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; Infectious Diseases Translational Research Program, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Boon LH; Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Cui J; Immunology Translational Research Program, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; NUS Immunology Program, Life Sciences Institute, National University of Singapore, Singapore, Singapore.; NUS-Cambridge Immune Phenotyping Centre (NCIPC), Life Sciences Institute, National University of Singapore, Singapore, Singapore., Juequn Z; Metabolic Core, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Shunmuganathan B; Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; NUS-Cambridge Immune Phenotyping Centre (NCIPC), Life Sciences Institute, National University of Singapore, Singapore, Singapore.; Antibody Engineering Programme, Life Sciences Institute, National University of Singapore, Singapore, Singapore., Gupta R; Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; NUS-Cambridge Immune Phenotyping Centre (NCIPC), Life Sciences Institute, National University of Singapore, Singapore, Singapore., Tan NYJ; Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; NUS-Cambridge Immune Phenotyping Centre (NCIPC), Life Sciences Institute, National University of Singapore, Singapore, Singapore., Qian X; Antibody Engineering Programme, Life Sciences Institute, National University of Singapore, Singapore, Singapore., Purushotorman K; Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; NUS-Cambridge Immune Phenotyping Centre (NCIPC), Life Sciences Institute, National University of Singapore, Singapore, Singapore.; Antibody Engineering Programme, Life Sciences Institute, National University of Singapore, Singapore, Singapore., Fong SW; A*STAR Infectious Diseases Labs (A*STAR ID Labs), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore., Renia L; A*STAR Infectious Diseases Labs (A*STAR ID Labs), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore.; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore., Ng LFP; A*STAR Infectious Diseases Labs (A*STAR ID Labs), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore., Angeli V; Immunology Translational Research Program, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Chen J; Immunology Translational Research Program, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore., Kennedy BK; Healthy Longevity Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; Department of Biochemistry and Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Ong CWM; Infectious Diseases Translational Research Program, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; Institute for Health Innovation and Technology, National University of Singapore, Singapore, Singapore.; Division of Infectious Diseases, Department of Medicine, National University Hospital, Singapore, Singapore., Macary PA; Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; NUS-Cambridge Immune Phenotyping Centre (NCIPC), Life Sciences Institute, National University of Singapore, Singapore, Singapore.; Antibody Engineering Programme, Life Sciences Institute, National University of Singapore, Singapore, Singapore.

Publikováno v: Aging cell [Aging Cell] 2024 Apr; Vol. 23 (4), pp. e14099. Date of Electronic Publication: 2024 Feb 05.

Standards for clinical trials for treating TB.

Autor: du Cros P; Burnet Institute, Melbourne, VIC, Monash Infectious Diseases, Monash Health, Melbourne, VIC, Australia., Greig J; Burnet Institute, Melbourne, VIC, Médecins Sans Frontières (MSF), Manson Unit, London, UK., Alffenaar JC; Sydney Infectious Diseases Institute (Sydney ID), and, School of Pharmacy, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, Westmead Hospital, Sydney, NSW., Cross GB; Burnet Institute, Melbourne, VIC, Kirby Institute, University of New South Wales, Sydney, NSW, Australia., Cousins C; Department of Pharmacology and Therapeutics, University of Liverpool, Liverpool, Institute of Clinical Trials and Methodology, University College London, London, UK., Berry C; Médecins Sans Frontières (MSF), Manson Unit, London, UK., Khan U; Interactive Research and Development Global, Singapore City, Singapore., Phillips PPJ; UCSF Center for Tuberculosis, Division of Pulmonary and Critical Care Medicine, and., Velásquez GE; UCSF Center for Tuberculosis, Division of HIV, Infectious Diseases, and Global Medicine, University of California, San Francisco, San Francisco, CA., Furin J; Harvard Medical School, Department of Global Health and Social Medicine, Boston, MA., Spigelman M; Global Alliance for TB Drug Development, New York, NY, USA., Denholm JT; Victorian Tuberculosis Program, Melbourne Health, Melbourne, VIC, Department of Infectious Diseases, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, VIC, Australia., Thi SS; Eswatini National TB Control Program, Mbabane, Kingdom of Eswatini., Tiberi S; Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, GlaxoSmithKline, London, UK., Huang GKL; Burnet Institute, Melbourne, VIC, Northern Health Infectious Diseases, Northern Health, Melbourne, VIC., Marks GB; School of Clinical Medicine, University of New South Wales, Sydney, NSW, Australia., Turkova A; Medical Research Council Clinical Trials Unit at University College London, London, UK., Guglielmetti L; Médecins Sans Frontières (MSF), Paris, Sorbonne Université, Institut national de la santé et de la recherche médicale, Unité 1135, Centre d'Immunologie et des Maladies Infectieuses, Paris, Assistance Publique Hôpitaux de Paris (APHP), Groupe Hospitalier Universitaire Sorbonne Université, Hôpital Pitié-Salpêtrière, Centre National de Référence des Mycobactéries et de la Résistance des Mycobactéries, Paris, France., Chew KL; Department of Laboratory Medicine, National University Hospital, Singapore City, Singapore., Nguyen HT; Research Department, Friends for International TB Relief, Ha Noi, Vietnam., Ong CWM; Infectious Diseases Translational Research Programme, Department of Medicine, National University of Singapore, Singapore City, Division of Infectious Diseases, Department of Medicine, National University Hospital, Singapore City, Institute of Healthcare Innovation & Technology, National University of Singapore, Singapore City, Singapore., Brigden G; The Global Fund, Geneva, Switzerland., Singh KP; Department of Infectious Diseases, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, VIC, Australia, Victorian Infectious Disease Unit, Royal Melbourne Hospital, Melbourne, VIC, Australia., Motta I; MSF, Geneva, Switzerland., Lange C; Division of Clinical Infectious Diseases, Research Center Borstel, Borstel, German Center for Infection Research (DZIF), TTU-TB, Borstel, Respiratory Medicine & International Health, University of Lübeck, Lübeck, Germany, Baylor College of Medicine and Texas Children's Hospital, Houston, TX, USA., Seddon JA; Department of Infectious Disease, Imperial College London, London, UK, Desmond Tutu TB Centre, Department of Paediatrics and Child Health, Stellenbosch University, Tygerberg, South Africa., Nyang'wa BT; Public Health Department, Operational Center Amsterdam (OCA), MSF, Amsterdam, The Netherlands., Maug AKJ; Damien Foundation Bangladesh, Dhaka, Bangladesh., Gler MT; De La Salle Medical and Health Sciences Institute, Dasmariñas, the Philippines., Dooley KE; Division of Infectious Diseases, Vanderbilt University Medical Center, Nashville, TN, USA., Quelapio M; Tropical Disease Foundation, Makati City, Manila, the Philippines, KNCV Tuberculosis Foundation, The Hague, The Netherlands., Tsogt B; Mongolian Anti-TB Coalition, Ulaanbaatar, Mongolia., Menzies D; Respiratory Epidemiology and Clinical Research Unit, Montreal Chest Institute & McGill International TB Centre, Montreal, QC, Canada., Cox V; Centre for Infectious Disease Epidemiology and Research, School of Public Health and Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town., Upton CM; TASK Applied Science, Cape Town, South Africa., Skrahina A; The Republican Scientific and Practical Center for Pulmonology and TB, Minsk, Belarus., McKenna L; Treatment Action Group, New York, NY., Horsburgh CR; Departments of Global Health, Epidemiology, Biostatistics and Medicine, Schools of Public Health and Medicine, Boston University, Boston MA, USA., Dheda K; Centre for Lung Infection and Immunity, Division of Pulmonology, Department of Medicine and UCT Lung Institute & South African MRC/UCT Centre for the Study of Antimicrobial Resistance, University of Cape Town, Cape Town, South Africa, Faculty of Infectious and Tropical Diseases, Department of Immunology and Infection, London School of Hygiene & Tropical Medicine, London, UK., Marais BJ; Sydney Infectious Diseases Institute (Sydney ID), and, The Children's Hospital at Westmead, Sydney, NSW, WHO Collaborating Centre in Tuberculosis, The University of Sydney, Sydney, NSW, Australia.

Publikováno v: The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease [Int J Tuberc Lung Dis] 2023 Dec 01; Vol. 27 (12), pp. 885-898.