Strategic Fluorination to Achieve a Potent, Selective, Metabolically Stable, and Orally Bioavailable Inhibitor of CSNK2.

Autor: Ong, Han Wee^1,2 (AUTHOR) onghw@live.unc.edu, Yang, Xuan^1,2 (AUTHOR), Smith, Jeffery L.² (AUTHOR), Taft-Benz, Sharon^1,3 (AUTHOR), Howell, Stefanie² (AUTHOR), Dickmander, Rebekah J.^1,4,5,6 (AUTHOR), Havener, Tammy M.² (AUTHOR), Sanders, Marcia K.^1,3 (AUTHOR), Brown, Jason W.⁷ (AUTHOR), Couñago, Rafael M.^2,8 (AUTHOR), Chang, Edcon⁷ (AUTHOR), Krämer, Andreas⁹ (AUTHOR), Moorman, Nathaniel J.^1,4,5 (AUTHOR), Heise, Mark^1,3 (AUTHOR), Axtman, Alison D.^1,2 (AUTHOR), Drewry, David H.^1,2,5 (AUTHOR), Willson, Timothy M.^1,2 (AUTHOR)

Publikováno v: Molecules. Sep2024, Vol. 29 Issue 17, p4158. 23p.

Discovery of potent Plasmodium falciparum protein kinase 6 (PfPK6) inhibitors with a type II inhibitor pharmacophore

Autor: Ong, Han Wee, Truong, Anna, Kwarcinski, Frank, de Silva, Chandi, Avalani, Krisha, Havener, Tammy M., Chirgwin, Michael, Galal, Kareem A., Willis, Caleb, Krämer, Andreas, Liu, Shubin, Knapp, Stefan, Derbyshire, Emily R., Zutshi, Reena, Drewry, David H.

Publikováno v: In European Journal of Medicinal Chemistry 5 March 2023 249

More than an Amide Bioisostere: Discovery of 1,2,4-Triazole-containing Pyrazolo[1,5‑a]pyrimidine Host CSNK2 Inhibitors for Combatting β‑Coronavirus Replication.

Autor: Ong, Han Wee, Yang, Xuan, Smith, Jeffery L., Dickmander, Rebekah J., Brown, Jason W., Havener, Tammy M., Taft-Benz, Sharon, Howell, Stefanie, Sanders, Marcia K., Capener, Jacob L., Couñago, Rafael M., Chang, Edcon, Krämer, Andreas, Moorman, Nathaniel J., Heise, Mark, Axtman, Alison D., Drewry, David H., Willson, Timothy M.

Publikováno v: Journal of Medicinal Chemistry; 7/25/2024, Vol. 67 Issue 14, p12261-12313, 53p

Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.

Characterization of 2,4-Dianilinopyrimidines Against Five P. falciparum Kinases PfARK1, PfARK3, PfNEK3, PfPK9, and PfPKB.

Autor: Ong, Han Wee, de Silva, Chandi, Avalani, Krisha, Kwarcinski, Frank, Mansfield, Christopher R., Chirgwin, Michael, Truong, Anna, Derbyshire, Emily R., Zutshi, Reena, Drewry, David H.

Publikováno v: ACS Medicinal Chemistry Letters; 12/14/2023, Vol. 14 Issue 12, p1774-1784, 11p