Zobrazeno 1 - 10
of 83
pro vyhledávání: '"Ong, HX"'
OBJECTIVES: A human nasal epithelial mucosa (NEM) on-a-chip is developed integrated with a novel carbon nanofibers-modified carbon electrode for real-time quantitative monitoring of in vitro nasal drug delivery. The integration of platinum electrodes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______363::6fa562d3ddd998ab9d6ec5d02742d424
https://hdl.handle.net/10453/157485
https://hdl.handle.net/10453/157485
Autor:
Sheikh, Z, Bradbury, P, Reekie, TA, Pozzoli, M, Robinson, PD, Kassiou, M, Young, PM, Ong, HX, Traini, D
Current cystic fibrosis (CF) treatment strategies are primarily focused on oral/inhaled anti-inflammatories and antibiotics, resulting in a considerable treatment burden for CF patients. Therefore, combination treatments consisting of anti-inflammato
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______363::ac2fbcff518f5323340a33d5091e0f8d
https://hdl.handle.net/10453/157486
https://hdl.handle.net/10453/157486
Background: Lymphangioleiomyomatosis (LAM) is characterized by growth of smooth muscle-like cells in the lungs that spread to other organs via lymphatic vessels. Current oral rapamycin treatment is limited by low bioavailability of approximately 15%.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______363::c76b15bff0407cda76bc4047bc44ac1a
https://hdl.handle.net/10453/149370
https://hdl.handle.net/10453/149370
For the past 50 years, the route of inhalation has been utilized to administer therapies to treat a variety of respiratory and pulmonary diseases. When compared with other drug administration routes, inhalation offers a targeted, non-invasive approac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______363::043c9e82c2f4928a5c8a1a67ae18a6c6
https://hdl.handle.net/10453/146860
https://hdl.handle.net/10453/146860
© 2018 Elsevier B.V. Despite many therapeutic advancements over the past decade, the continued rise in chronic inflammatory lung diseases incidence has driven the need to identify and develop new therapeutic strategies, with superior efficacy to tre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______363::8d8aca7bdcdf233a6fe3e0b29d94f8d1
https://hdl.handle.net/10453/128757
https://hdl.handle.net/10453/128757
© 2016 Elsevier B.V. The aim of this study was to incorporate an optimized RPMI2650 nasal cell model into a 3D printed model of the nose to test deposition and permeation of drugs intended for use in the nose. The nasal cell model was optimized for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______363::e5e3397f86d41706b2a32a7c27c031b6
https://hdl.handle.net/10453/48385
https://hdl.handle.net/10453/48385
© 2014 Elsevier Inc. During the process of inhalable formulation development a deep knowledge of the physicochemical characteristics of the drug and formulation components and the biological properties of the airways is necessary. For example, the s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______363::4fa4269a0b8ae59ff457c095a60431ba
https://hdl.handle.net/10453/32643
https://hdl.handle.net/10453/32643
Liposomal ciprofloxacin formulations have been developed with the aim of enhancing lung residence time, thereby reducing the burden of inhaled antimicrobial therapy which requires multiple daily administration due to rapid absorptive clearance of ant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______363::d39abdb2520c728f056152489b981441
https://hdl.handle.net/10453/36408
https://hdl.handle.net/10453/36408
Ciprofloxacin is a well-established broad-spectrum fluoroquinolone antibiotic that penetrates well into the lung tissues; still, the mechanisms of its transepithelial transport are unknown. The contributions of specific transporters, including multid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______363::c567b2754c9fa2d6b4a91b5973cf9361
https://hdl.handle.net/10453/23650
https://hdl.handle.net/10453/23650