Zobrazeno 1 - 10
of 185
pro vyhledávání: '"Ong, A.C.M."'
Autor:
Valluru, M.K., Chung, N.K.X., Gilchrist, M., Butland, L., Cook, J., Takou, A., Dixit, A., Weedon, M.N., Ong, A.C.M.
Background Monogenic disorders are estimated to account for 10%–12% of patients with kidney failure. We report the unexpected finding of an unusual uromodulin (UMOD) variant in multiple pedigrees within the British population and demonstrate a shar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::d7aa7b92fe7c67e33839c130ab88c4bc
https://eprints.whiterose.ac.uk/190671/1/jmg-2022-108704.full.pdf
https://eprints.whiterose.ac.uk/190671/1/jmg-2022-108704.full.pdf
Autor:
Perrone, R.D., Hariri, A., Minini, P., Ahn, C., Chapman, A.B., Horie, S., Knebelmann, B., Mrug, M., Ong, A.C.M., Pei, Y.P.C., Torres, V.E., Modur, V., Gansevoort, R.T.
Rationale & Objective\ud \ud Venglustat, a glucosylceramide synthase inhibitor, inhibits cyst growth and reduces kidney failure in mouse models of autosomal dominant polycystic kidney disease (ADPKD). STAGED-PKD aims to determine the safety and effic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::82ab96cbbb66cfe007ba07db2020f603
https://eprints.whiterose.ac.uk/190654/1/1-s2.0-S2590059522001601-main.pdf
https://eprints.whiterose.ac.uk/190654/1/1-s2.0-S2590059522001601-main.pdf
Akademický článek
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Metformin induces lactate accumulation and accelerates renal cyst progression in Pkd1-deficient mice
Autor:
Chang, M.-Y., Tsai, T.-I., Chou, L.-F., Hsu, S.H., Yang, H.-Y., Hung, C.-C., Tian, Y.-C., Ong, A.C.M., Yang, C.-W.
Metabolic reprogramming is a potential treatment strategy for autosomal dominant polycystic kidney disease (ADPKD). Metformin has been shown to inhibit the early stages of cyst formation in animal models. However, metformin can lead to lactic acidosi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::fab46b13acfde63294ebff30d5c1255d
Autor:
Ong, A.C.M., Torra, R.
Autosomal dominant polycystic kidney disease (ADPKD) is the most common inherited kidney disease leading to kidney failure. To date there is no cure for the disease although there is one approved disease modifying therapy, tolvaptan. In this context,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::7e5604ba4b249a0d9e844c6baa4166dd
https://eprints.whiterose.ac.uk/186898/7/sfac103.pdf
https://eprints.whiterose.ac.uk/186898/7/sfac103.pdf
Akademický článek
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Akademický článek
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Background\ud \ud Everolimus is a potential alternative to embolization and nephrectomy for managing tuberous sclerosis complex (TSC)-associated renal angiomyolipoma (AML). In 2016, National Health Service England approved its use through regional ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::c172d6ee3a57c08c3041dbea3450c91d
https://eprints.whiterose.ac.uk/186896/1/chung.EveTSShef.CKJ2022.pdf
https://eprints.whiterose.ac.uk/186896/1/chung.EveTSShef.CKJ2022.pdf
Autor:
Senum, S.R., Li, Y.M., Benson, K.A., Joli, G., Olinger, E., Lavu, S., Madsen, C.D., Gregory, A.V., Neatu, R., Kline, T.L., Audrezet, M.P., Outeda, P., Nau, C.B., Meijer, E., Ali, H., Steinman, T.I., Mrug, M., Phelan, P.J., Watnick, T.J., Peters, D.J.M., Ong, A.C.M., Conlon, P.J., Perrone, R.D., Gall, E.C.L., Hogan, M.C., Torres, V.E., Saver, J.A., Harris, P.C., Genomics England Res Consortium, HALT PKD, CRISP, DIPAK, ADPKD Modifier, TAME PKD studies
Publikováno v:
Am J Hum Genet
American Journal of Human Genetics, 109(1), 136-156. CELL PRESS
American Journal of Human Genetics
American Journal of Human Genetics, Elsevier (Cell Press), 2022, 109 (1), pp.136-156. ⟨10.1016/j.ajhg.2021.11.016⟩
American Journal of Human Genetics, 109(1), 136-156. CELL PRESS
American Journal of Human Genetics
American Journal of Human Genetics, Elsevier (Cell Press), 2022, 109 (1), pp.136-156. ⟨10.1016/j.ajhg.2021.11.016⟩
International audience; Autosomal dominant polycystic kidney disease (ADPKD), characterized by progressive cyst formation/expansion, results in enlarged kidneys and often end stage kidney disease. ADPKD is genetically heterogeneous; PKD1 and PKD2 are
Autor:
Ong, A.C.M., Gansevoort, R.T.
The biguanide metformin has been safely and widely used in the treatment of type 2 diabetes mellitus for decades. Preclinical studies have suggested that it may have a role in slowing disease progression in autosomal dominant polycystic kidney diseas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::3412b98490ef9a5993edb7155d7e35c2